The beta(3) adrenoceptor agonist, amibegron (SR58611A)
counteracts stress-induced behavioral and neurochemical changes

J 2010

The beta(3) adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes

TAMBURELLA, Alessandra; Vincenzo MICALE; Gian Marco LEGGIO a Filippo DRAGO

Základní údaje

Originální název

The beta(3) adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes

Autoři

TAMBURELLA, Alessandra; Vincenzo MICALE; Gian Marco LEGGIO a Filippo DRAGO

Vydání

European Neuropsychopharmacology, Amsterdam, Elsevier, 2010, 0924-977X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.201

Označené pro přenos do RIV

DOI

https://doi.org/10.1016/j.euroneuro.2010.04.006

UT WoS

000282241000006

Klíčová slova anglicky

beta(3) adrenoceptors; Restraint stress; Neurotrophic factors; Forced swim test; Amibegron

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 8. 2012 07:06, Olga Křížová

Anotace

V originále

These experiments were made to study the mechanisms underlying the antidepressant-like effects of the beta(3) adrenoceptor agonist amibegron (SR58611A). To this purpose, the expression levels of the hippocampal cyclic adenosine monophosphate (cAMP)-response element binding protein (CREB), brain-derived neurotrophic factor (BDNF), B-cell lymphoma-2 (Bcl-2) and Bax proteins were assessed, by using western blot analysis, in rats tested in the forced swim test (FST). Under basal conditions (no previous exposure to stressors), different groups of male Wistar rats received acutely or repeatedly (once/day for 7 days) intraperitoneal (i.p.) injections of amibegron (1, 5 and 10 mg/kg), the tricyclic antidepressant (TCA) clomipramine (50 mg/kg), the selective serotonin reuptake inhibitor (SSRI) citalopram (15 mg/kg) or their vehicles. The influence of stress-related conditions was studied in rats subjected to acute (4 h) or repeated (4 h/day for 7 days) restraint stress, applied prior to the FST procedure. Compared to the control groups, both stressor procedures increased the immobility time in the FST and reduced hippocampal BDNF and Bcl-2/Bax ratio proteins expression, which were counteracted by amibegron (5 and 10 mg/kg) treatment. Opposite effects were found in the CREB expression, since it was lower after acute and higher after repeated stress procedure, respectively. Again, these effects were reversed by amibegron treatment. Different results were obtained in animals treated with clomipramine or citalopram. Hence, it is likely that the observed behavioral effects of amibegron could be due, at least in part, to its action on hippocampal expression of neurotrophic and/or anti-apoptotic factors, supporting the hypothesis that beta 3 adrenoceptors may be a therapeutic target for the treatment of stress-related disorders. (c) 2010 Elsevier B.V. and ECNP. All rights reserved.

Citovat

TAMBURELLA, Alessandra; Vincenzo MICALE; Gian Marco LEGGIO a Filippo DRAGO. The beta(3) adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes. European Neuropsychopharmacology. Amsterdam: Elsevier, 2010, roč. 20, č. 10, s. 704-713. ISSN 0924-977X. Dostupné z: https://doi.org/10.1016/j.euroneuro.2010.04.006.

@article{988758,
   author = {Tamburella, Alessandra and Micale, Vincenzo and Leggio, Gian Marco and Drago, Filippo},
   article_location = {Amsterdam},
   article_number = {10},
   doi = {https://doi.org/10.1016/j.euroneuro.2010.04.006},
   keywords = {beta(3) adrenoceptors; Restraint stress; Neurotrophic factors; Forced swim test; Amibegron},
   language = {eng},
   issn = {0924-977X},
   journal = {European Neuropsychopharmacology},
   title = {The beta(3) adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes},
   volume = {20},
   year = {2010}
}

TY  - JOUR
ID  - 988758
AU  - Tamburella, Alessandra - Micale, Vincenzo - Leggio, Gian Marco - Drago, Filippo
PY  - 2010
TI  - The beta(3) adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes
JF  - European Neuropsychopharmacology
VL  - 20
IS  - 10
SP  - 704-713
EP  - 704-713
PB  - Elsevier
SN  - 0924977X
KW  - beta(3) adrenoceptors
KW  - Restraint stress
KW  - Neurotrophic factors
KW  - Forced swim test
KW  - Amibegron
N2  - These experiments were made to study the mechanisms underlying the antidepressant-like effects of the beta(3) adrenoceptor agonist amibegron (SR58611A). To this purpose, the expression levels of the hippocampal cyclic adenosine monophosphate (cAMP)-response element binding protein (CREB), brain-derived neurotrophic factor (BDNF), B-cell lymphoma-2 (Bcl-2) and Bax proteins were assessed, by using western blot analysis, in rats tested in the forced swim test (FST). Under basal conditions (no previous exposure to stressors), different groups of male Wistar rats received acutely or repeatedly (once/day for 7 days) intraperitoneal (i.p.) injections of amibegron (1, 5 and 10 mg/kg), the tricyclic antidepressant (TCA) clomipramine (50 mg/kg), the selective serotonin reuptake inhibitor (SSRI) citalopram (15 mg/kg) or their vehicles. The influence of stress-related conditions was studied in rats subjected to acute (4 h) or repeated (4 h/day for 7 days) restraint stress, applied prior to the FST procedure. Compared to the control groups, both stressor procedures increased the immobility time in the FST and reduced hippocampal BDNF and Bcl-2/Bax ratio proteins expression, which were counteracted by amibegron (5 and 10 mg/kg) treatment. Opposite effects were found in the CREB expression, since it was lower after acute and higher after repeated stress procedure, respectively. Again, these effects were reversed by amibegron treatment. Different results were obtained in animals treated with clomipramine or citalopram. Hence, it is likely that the observed behavioral effects of amibegron could be due, at least in part, to its action on hippocampal expression of neurotrophic and/or anti-apoptotic factors, supporting the hypothesis that beta 3 adrenoceptors may be a therapeutic target for the treatment of stress-related disorders. (c) 2010 Elsevier B.V. and ECNP. All rights reserved.
ER  -

TAMBURELLA, Alessandra; Vincenzo MICALE; Gian Marco LEGGIO a Filippo DRAGO. The beta(3) adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes. \textit{European Neuropsychopharmacology}. Amsterdam: Elsevier, 2010, roč.~20, č.~10, s.~704-713. ISSN~0924-977X. Dostupné z: https://doi.org/10.1016/j.euroneuro.2010.04.006.

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