Prolonged fear incubation leads to generalized avoidance
behavior in mice

J 2011

Prolonged fear incubation leads to generalized avoidance behavior in mice

PAMPLONA, F A; K HENES; Vincenzo MICALE; C P MAUCH; R N TAKAHASHI et al.

Základní údaje

Originální název

Prolonged fear incubation leads to generalized avoidance behavior in mice

Autoři

PAMPLONA, F A; K HENES; Vincenzo MICALE; C P MAUCH; R N TAKAHASHI a Carsten T WOTJAK

Vydání

Journal of Psychiatric Research, OXFORD, Elsevier, 2011, 0022-3956

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.664

Označené pro přenos do RIV

DOI

https://doi.org/10.1016/j.jpsychires.2010.06.015

UT WoS

000288723800009

Klíčová slova anglicky

Post-traumatic stress disorder; PTSD; Avoidance; Fear incubation; Conditioned fear

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 8. 2012 07:33, Olga Křížová

Anotace

V originále

Long-lasting presence of avoidance and emotional numbing are reliable behavioral markers for PTSD, but little is known about its psychological and biological underpinnings. We employed our recently established mouse model of PTSD (i) to study the emergence of avoidance behavior in the aftermath of a trauma, (ii) to disentangle the impact of context generalization vs. lack of motivation vs. novelty fear and (iii) to assess the therapeutic value of benzodiazepines and selective serotonin reuptake inhibitors (SSRIs). Specific conditioned avoidance to shock-paired odor turned into generalized avoidance after 28 days of fear incubation. Combination of habituation to the novel environment and extinction of contextual fear abolished both generalized and specific avoidance behavior. Chronic fluoxetine treatment partially reversed the phenotype, whereas acute treatment with diazepam did not. Our animal model may help understanding the mechanisms underlying psychological and biological mechanisms of PTSD for the benefit of developing pharmacotherapeutic strategies, which specifically address generalized avoidance. (C) 2010 Elsevier Ltd. All rights reserved.

Citovat

PAMPLONA, F A; K HENES; Vincenzo MICALE; C P MAUCH; R N TAKAHASHI a Carsten T WOTJAK. Prolonged fear incubation leads to generalized avoidance behavior in mice. Journal of Psychiatric Research. OXFORD: Elsevier, 2011, roč. 45, č. 3, s. 354-360. ISSN 0022-3956. Dostupné z: https://doi.org/10.1016/j.jpsychires.2010.06.015.

@article{988762,
   author = {Pamplona, F A and Henes, K and Micale, Vincenzo and Mauch, C P and Takahashi, R N and Wotjak, Carsten T},
   article_location = {OXFORD},
   article_number = {3},
   doi = {https://doi.org/10.1016/j.jpsychires.2010.06.015},
   keywords = {Post-traumatic stress disorder; PTSD; Avoidance; Fear incubation; Conditioned fear},
   language = {eng},
   issn = {0022-3956},
   journal = {Journal of Psychiatric Research},
   title = {Prolonged fear incubation leads to generalized avoidance behavior in mice},
   volume = {45},
   year = {2011}
}

TY  - JOUR
ID  - 988762
AU  - Pamplona, F A - Henes, K - Micale, Vincenzo - Mauch, C P - Takahashi, R N - Wotjak, Carsten T
PY  - 2011
TI  - Prolonged fear incubation leads to generalized avoidance behavior in mice
JF  - Journal of Psychiatric Research
VL  - 45
IS  - 3
SP  - 354-360
EP  - 354-360
PB  - Elsevier
SN  - 00223956
KW  - Post-traumatic stress disorder
KW  - PTSD
KW  - Avoidance
KW  - Fear incubation
KW  - Conditioned fear
N2  - Long-lasting presence of avoidance and emotional numbing are reliable behavioral markers for PTSD, but little is known about its psychological and biological underpinnings. We employed our recently established mouse model of PTSD (i) to study the emergence of avoidance behavior in the aftermath of a trauma, (ii) to disentangle the impact of context generalization vs. lack of motivation vs. novelty fear and (iii) to assess the therapeutic value of benzodiazepines and selective serotonin reuptake inhibitors (SSRIs). Specific conditioned avoidance to shock-paired odor turned into generalized avoidance after 28 days of fear incubation. Combination of habituation to the novel environment and extinction of contextual fear abolished both generalized and specific avoidance behavior. Chronic fluoxetine treatment partially reversed the phenotype, whereas acute treatment with diazepam did not. Our animal model may help understanding the mechanisms underlying psychological and biological mechanisms of PTSD for the benefit of developing pharmacotherapeutic strategies, which specifically address generalized avoidance. (C) 2010 Elsevier Ltd. All rights reserved.
ER  -

PAMPLONA, F A; K HENES; Vincenzo MICALE; C P MAUCH; R N TAKAHASHI a Carsten T WOTJAK. Prolonged fear incubation leads to generalized avoidance behavior in mice. \textit{Journal of Psychiatric Research}. OXFORD: Elsevier, 2011, roč.~45, č.~3, s.~354-360. ISSN~0022-3956. Dostupné z: https://doi.org/10.1016/j.jpsychires.2010.06.015.

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