Dual effects of melatonin on barbiturate-induced narcosis in
rats

J 2001

Dual effects of melatonin on barbiturate-induced narcosis in rats

DRAGO, Filipo; M FRISINA; Martin GRECH; A NICOLOSI; Vincenzo MICALE et al.

Základní údaje

Originální název

Dual effects of melatonin on barbiturate-induced narcosis in rats

Autoři

DRAGO, Filipo; M FRISINA; Martin GRECH; A NICOLOSI; Vincenzo MICALE; A NICOSIA; M MEDICO a F FOTI

Vydání

Neuroscience Letters, CLARE, Elsevier, 2001, 0304-3940

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.021

Označené pro přenos do RIV

DOI

https://doi.org/10.1016/S0304-3940(01)01578-6

UT WoS

000167443400012

Klíčová slova anglicky

melatonin; sodium thiopenthal; narcosis; ketamine; diazepam; low doses

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 8. 2012 07:32, Olga Křížová

Anotace

V originále

Melatonin affects the circadian sleep/wake cycle, but it is not clear whether it may influence drug-induced narcosis. Sodium thiopenthal was administered intraperitoneally into male rats pre-treated with melatonin (0.05, 0.5, 5 and 50 mg/kg). Melatonin pre-treatment affected in a dual manner barbiturate narcosis, however, no dose-effect correlation was found. In particular, low doses reduced the latency to and prolonged the duration of barbiturate narcosis. In contrast, the highest dose of melatonin (50 mg/kg) caused a paradoxical increase in the latency and produced a sustained reduction of the duration of narcosis, and a reduction in mortality rate. Melatonin 0.5 and 5 mg/kg influenced the duration but not the latency of ketamine- or diazepam-induced narcosis. Thus, the dual action of melatonin on pharmacological narcosis seems to be specific for the barbiturate mechanism of action. (C) 2001 Published by Elsevier Science ireland Ltd.

Citovat

DRAGO, Filipo; M FRISINA; Martin GRECH; A NICOLOSI; Vincenzo MICALE; A NICOSIA; M MEDICO a F FOTI. Dual effects of melatonin on barbiturate-induced narcosis in rats. Neuroscience Letters. CLARE: Elsevier, 2001, roč. 300, č. 3, s. 176-178. ISSN 0304-3940. Dostupné z: https://doi.org/10.1016/S0304-3940(01)01578-6.

@article{988763,
   author = {Drago, Filipo and Frisina, M and Grech, Martin and Nicolosi, A and Micale, Vincenzo and Nicosia, A and Medico, M and Foti, F},
   article_location = {CLARE},
   article_number = {3},
   doi = {https://doi.org/10.1016/S0304-3940(01)01578-6},
   keywords = {melatonin; sodium thiopenthal; narcosis; ketamine; diazepam; low doses},
   language = {eng},
   issn = {0304-3940},
   journal = {Neuroscience Letters},
   title = {Dual effects of melatonin on barbiturate-induced narcosis in rats},
   volume = {300},
   year = {2001}
}

TY  - JOUR
ID  - 988763
AU  - Drago, Filipo - Frisina, M - Grech, Martin - Nicolosi, A - Micale, Vincenzo - Nicosia, A - Medico, M - Foti, F
PY  - 2001
TI  - Dual effects of melatonin on barbiturate-induced narcosis in rats
JF  - Neuroscience Letters
VL  - 300
IS  - 3
SP  - 176-178
EP  - 176-178
PB  - Elsevier
SN  - 03043940
KW  - melatonin
KW  - sodium thiopenthal
KW  - narcosis
KW  - ketamine
KW  - diazepam
KW  - low doses
N2  - Melatonin affects the circadian sleep/wake cycle, but it is not clear whether it may influence drug-induced narcosis. Sodium thiopenthal was administered intraperitoneally into male rats pre-treated with melatonin (0.05, 0.5, 5 and 50 mg/kg). Melatonin pre-treatment affected in a dual manner barbiturate narcosis, however, no dose-effect correlation was found. In particular, low doses reduced the latency to and prolonged the duration of barbiturate narcosis. In contrast, the highest dose of melatonin (50 mg/kg) caused a paradoxical increase in the latency and produced a sustained reduction of the duration of narcosis, and a reduction in mortality rate. Melatonin 0.5 and 5 mg/kg influenced the duration but not the latency of ketamine- or diazepam-induced narcosis. Thus, the dual action of melatonin on pharmacological narcosis seems to be specific for the barbiturate mechanism of action. (C) 2001 Published by Elsevier Science ireland Ltd.
ER  -

DRAGO, Filipo; M FRISINA; Martin GRECH; A NICOLOSI; Vincenzo MICALE; A NICOSIA; M MEDICO a F FOTI. Dual effects of melatonin on barbiturate-induced narcosis in rats. \textit{Neuroscience Letters}. CLARE: Elsevier, 2001, roč.~300, č.~3, s.~176-178. ISSN~0304-3940. Dostupné z: https://doi.org/10.1016/S0304-3940(01)01578-6.

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