Placebo affects the performance of rats in models of
depression: is it a good control for behavioral experiments?

J 2001

Placebo affects the performance of rats in models of depression: is it a good control for behavioral experiments?

DRAGO, Filipo; A NICOLOSI; Vincenzo MICALE a G LO MENZO

Základní údaje

Originální název

Placebo affects the performance of rats in models of depression: is it a good control for behavioral experiments?

Autoři

DRAGO, Filipo; A NICOLOSI; Vincenzo MICALE a G LO MENZO

Vydání

European Neuropsychopharmacology, Amsterdam (The Netherlands), Elsevier, 2001, 0924-977X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.437

Označené pro přenos do RIV

DOI

https://doi.org/10.1016/S0924-977X(01)00084-0

UT WoS

000169938400003

Klíčová slova anglicky

placebo; clomipramine; models of depression; despair test; reserpine-induced behavioral changes; depression

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 8. 2012 07:30, Olga Křížová

Anotace

V originále

Experimental design of behavioral studies in animals generally includes placebo-treated controls. However, when placebo is administered by injection in experimental models of psychiatric diseases such as depression, where stress may affect the execution of the behavioral test, it is possible that injection per se may influence the behavioral response. Rats injected with clomipramine hydrochloride (1, 10 or 50 mg/kg), as compared to animals injected with physiological saline as placebo, showed a dose-dependent decrease of the immobility time in the despair test and of the number of floor units explored in the open field in the reserpine test. However, when animals injected with placebo or clomipramine 50 mg/kg were compared with untreated intact controls, it was found that the immobility time in the despair test was higher in the placebo-treated animals than in untreated intact controls. A difference was found between clomipramine-injected animals and untreated intact controls. In contrast, rats tested in the reserpine test. which is based on repeated drug injections, no difference was found between placebo-treated animals and untreated intact controls. These results indicate that stressful procedure of the experimental design may change the response of animals in behavioral tests. Studies with experimental models of depression, where stressful procedures are used, should include a control group of untreated intact animals. (C) 2001 Elsevier Science B.V./ECNP. All rights reserved.

Citovat

DRAGO, Filipo; A NICOLOSI; Vincenzo MICALE a G LO MENZO. Placebo affects the performance of rats in models of depression: is it a good control for behavioral experiments? European Neuropsychopharmacology. Amsterdam (The Netherlands): Elsevier, 2001, roč. 11, č. 3, s. 209-213. ISSN 0924-977X. Dostupné z: https://doi.org/10.1016/S0924-977X(01)00084-0.

@article{988764,
   author = {Drago, Filipo and Nicolosi, A and Micale, Vincenzo and Lo Menzo, G},
   article_location = {Amsterdam (The Netherlands)},
   article_number = {3},
   doi = {https://doi.org/10.1016/S0924-977X(01)00084-0},
   keywords = {placebo; clomipramine; models of depression; despair test; reserpine-induced behavioral changes; depression},
   language = {eng},
   issn = {0924-977X},
   journal = {European Neuropsychopharmacology},
   title = {Placebo affects the performance of rats in models of depression: is it a good control for behavioral experiments?},
   volume = {11},
   year = {2001}
}

TY  - JOUR
ID  - 988764
AU  - Drago, Filipo - Nicolosi, A - Micale, Vincenzo - Lo Menzo, G
PY  - 2001
TI  - Placebo affects the performance of rats in models of depression: is it a good control for behavioral experiments?
JF  - European Neuropsychopharmacology
VL  - 11
IS  - 3
SP  - 209-213
EP  - 209-213
PB  - Elsevier
SN  - 0924977X
KW  - placebo
KW  - clomipramine
KW  - models of depression
KW  - despair test
KW  - reserpine-induced behavioral changes
KW  - depression
N2  - Experimental design of behavioral studies in animals generally includes placebo-treated controls. However, when placebo is administered by injection in experimental models of psychiatric diseases such as depression, where stress may affect the execution of the behavioral test, it is possible that injection per se may influence the behavioral response. Rats injected with clomipramine hydrochloride (1, 10 or 50 mg/kg), as compared to animals injected with physiological saline as placebo, showed a dose-dependent decrease of the immobility time in the despair test and of the number of floor units explored in the open field in the reserpine test. However, when animals injected with placebo or clomipramine 50 mg/kg were compared with untreated intact controls, it was found that the immobility time in the despair test was higher in the placebo-treated animals than in untreated intact controls. A difference was found between clomipramine-injected animals and untreated intact controls. In contrast, rats tested in the reserpine test. which is based on repeated drug injections, no difference was found between placebo-treated animals and untreated intact controls. These results indicate that stressful procedure of the experimental design may change the response of animals in behavioral tests. Studies with experimental models of depression, where stressful procedures are used, should include a control group of untreated intact animals. (C) 2001 Elsevier Science B.V./ECNP. All rights reserved.
ER  -

DRAGO, Filipo; A NICOLOSI; Vincenzo MICALE a G LO MENZO. Placebo affects the performance of rats in models of depression: is it a good control for behavioral experiments? \textit{European Neuropsychopharmacology}. Amsterdam (The Netherlands): Elsevier, 2001, roč.~11, č.~3, s.~209-213. ISSN~0924-977X. Dostupné z: https://doi.org/10.1016/S0924-977X(01)00084-0.

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