Dopaminergic drugs may counteract behavioral and biochemical
changes induced by models of brain injury

J 2006

Dopaminergic drugs may counteract behavioral and biochemical changes induced by models of brain injury

MICALE, Vincenzo; T INCOGNITO; A IGNOTO; L RAMPELLO; M SPARTA et al.

Základní údaje

Originální název

Dopaminergic drugs may counteract behavioral and biochemical changes induced by models of brain injury

Autoři

MICALE, Vincenzo; T INCOGNITO; A IGNOTO; L RAMPELLO; M SPARTA a Filippo DRAGO

Vydání

European Neuropsychopharmacology, Amsterdam (The Netherlands), Elsevier, 2006, 0924-977X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.794

Označené pro přenos do RIV

DOI

https://doi.org/10.1016/j.euroneuro.2005.08.003

UT WoS

000236695700005

Klíčová slova anglicky

bromocriptine; cabergoline; dihydroergocryptine; pergolide; ropirinole; active and passive avoidance; hypobaric hypoxia; brain occlusive ischemia; kainate-induced convulsions; glutathione redox index

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 8. 2012 07:45, Olga Křížová

Anotace

V originále

The dopaminergic drugs, bromocriptine, cabergoline, dihydroergocryptine, pergolide and ropinirole were injected subcutaneously (s.c.) at the dose of 0.1, 0.5 and 1 mg/kg/day for 7 days into mate rats of the Sprague-Dawley strain. The drug pre-treatment reverted amnesia induced in rats by hypobaric hypopxia and tested in active and passive avoidance tasks. A restoration of memory retention, as assessed in a step-through passive avoidance task, was found in animals with a 2-month brain occlusive ischemia and exposed to dopaminergic drugs for 7 days. For behavioral effects in both active and passive avoidance tests in both experimental models, the rank of relative potency was ropirinole > bromocriptine = cabergoline > pergolide > dihydroergocryptine. Spontaneous ambulation of animals with brain occlusive ischemia was increased by the higher doses of drugs. All dopaminergic drugs reduced kainate mortality rate. The rank of relative potency for this effect was ropirinole=bromocriptine=cabergoline > pergotide=dihydroergocryptine. However, no change was found in other seizure parameters (latency to first convulsion and total number of convulsions) after drug treatment. A biochemical analysis of glutathione redox index (glutathione reduced/glutathione oxidized ratio) in discrete brain areas revealed that exposure to dopaminergic drugs increased this parameter in frontal cortex, striatum and hippocampus of animals subject to hypobaric hypoxia and brain occlusive ischemia. For this effect, the relative potency rank was ropirinole > bromocriptine = cabergoline >> pergolide=dihydroergocryptine. These behavioral and biochemical findings suggest that dopaminergic drugs may counteract either behavioral or biochemical changes induced by experimental models of brain injury. This activity was found after protective activity (as found in animals pre-treated with these drugs and exposed to hypobaric hypoxia) or reversal of brain injury (as found in animals treated after 2-month occlusive brain ischemia). Their neuroprotective activity probably involves the reduction/oxidation balance of the glutathione system in the brain. (c) 2005 Elsevier B.V. and ECNP. All rights reserved.

Citovat

MICALE, Vincenzo; T INCOGNITO; A IGNOTO; L RAMPELLO; M SPARTA a Filippo DRAGO. Dopaminergic drugs may counteract behavioral and biochemical changes induced by models of brain injury. European Neuropsychopharmacology. Amsterdam (The Netherlands): Elsevier, 2006, roč. 16, č. 3, s. 195-203. ISSN 0924-977X. Dostupné z: https://doi.org/10.1016/j.euroneuro.2005.08.003.

@article{988767,
   author = {Micale, Vincenzo and Incognito, T and Ignoto, A and Rampello, L and Sparta, M and Drago, Filippo},
   article_location = {Amsterdam (The Netherlands)},
   article_number = {3},
   doi = {https://doi.org/10.1016/j.euroneuro.2005.08.003},
   keywords = {bromocriptine; cabergoline; dihydroergocryptine; pergolide; ropirinole; active and passive avoidance; hypobaric hypoxia; brain occlusive ischemia; kainate-induced convulsions; glutathione redox index},
   language = {eng},
   issn = {0924-977X},
   journal = {European Neuropsychopharmacology},
   title = {Dopaminergic drugs may counteract behavioral and biochemical changes induced by models of brain injury},
   volume = {16},
   year = {2006}
}

TY  - JOUR
ID  - 988767
AU  - Micale, Vincenzo - Incognito, T - Ignoto, A - Rampello, L - Sparta, M - Drago, Filippo
PY  - 2006
TI  - Dopaminergic drugs may counteract behavioral and biochemical changes induced by models of brain injury
JF  - European Neuropsychopharmacology
VL  - 16
IS  - 3
SP  - 195-203
EP  - 195-203
PB  - Elsevier
SN  - 0924977X
KW  - bromocriptine
KW  - cabergoline
KW  - dihydroergocryptine
KW  - pergolide
KW  - ropirinole
KW  - active and passive avoidance
KW  - hypobaric hypoxia
KW  - brain occlusive ischemia
KW  - kainate-induced convulsions
KW  - glutathione redox index
N2  - The dopaminergic drugs, bromocriptine, cabergoline, dihydroergocryptine, pergolide and ropinirole were injected subcutaneously (s.c.) at the dose of 0.1, 0.5 and 1 mg/kg/day for 7 days into mate rats of the Sprague-Dawley strain. The drug pre-treatment reverted amnesia induced in rats by hypobaric hypopxia and tested in active and passive avoidance tasks. A restoration of memory retention, as assessed in a step-through passive avoidance task, was found in animals with a 2-month brain occlusive ischemia and exposed to dopaminergic drugs for 7 days. For behavioral effects in both active and passive avoidance tests in both experimental models, the rank of relative potency was ropirinole > bromocriptine = cabergoline > pergolide > dihydroergocryptine. Spontaneous ambulation of animals with brain occlusive ischemia was increased by the higher doses of drugs. All dopaminergic drugs reduced kainate mortality rate. The rank of relative potency for this effect was ropirinole=bromocriptine=cabergoline > pergotide=dihydroergocryptine. However, no change was found in other seizure parameters (latency to first convulsion and total number of convulsions) after drug treatment. A biochemical analysis of glutathione redox index (glutathione reduced/glutathione oxidized ratio) in discrete brain areas revealed that exposure to dopaminergic drugs increased this parameter in frontal cortex, striatum and hippocampus of animals subject to hypobaric hypoxia and brain occlusive ischemia. For this effect, the relative potency rank was ropirinole > bromocriptine = cabergoline >> pergolide=dihydroergocryptine. These behavioral and biochemical findings suggest that dopaminergic drugs may counteract either behavioral or biochemical changes induced by experimental models of brain injury. This activity was found after protective activity (as found in animals pre-treated with these drugs and exposed to hypobaric hypoxia) or reversal of brain injury (as found in animals treated after 2-month occlusive brain ischemia). Their neuroprotective activity probably involves the reduction/oxidation balance of the glutathione system in the brain. (c) 2005 Elsevier B.V. and ECNP. All rights reserved.
ER  -

MICALE, Vincenzo; T INCOGNITO; A IGNOTO; L RAMPELLO; M SPARTA a Filippo DRAGO. Dopaminergic drugs may counteract behavioral and biochemical changes induced by models of brain injury. \textit{European Neuropsychopharmacology}. Amsterdam (The Netherlands): Elsevier, 2006, roč.~16, č.~3, s.~195-203. ISSN~0924-977X. Dostupné z: https://doi.org/10.1016/j.euroneuro.2005.08.003.

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