Melatonin affects the immobility time of rats in the forced
swim test: The role of serotonin neurotransmission

J 2006

Melatonin affects the immobility time of rats in the forced swim test: The role of serotonin neurotransmission

MICALE, Vincenzo; Anna AREZZI; Liborio RAMPELLO a Filippo DRAGO

Základní údaje

Originální název

Melatonin affects the immobility time of rats in the forced swim test: The role of serotonin neurotransmission

Autoři

MICALE, Vincenzo; Anna AREZZI; Liborio RAMPELLO a Filippo DRAGO

Vydání

European Neuropsychopharmacology, Amsterdam (The Netherlands), Elsevier, 2006, 0924-977X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.794

Označené pro přenos do RIV

DOI

https://doi.org/10.1016/j.euroneuro.2006.01.005

UT WoS

000240969000008

Klíčová slova anglicky

melatonin; forced swim test; antidepressant activity; 5-HT; luzindole

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 8. 2012 07:47, Olga Křížová

Anotace

V originále

The efficacy of melatonin or its derivatives in depressive patients has been recently considered for clinical application. However, the evidence for its effect on experimental models of depression is not consolidated. Here, the effects of melatonin on the model of forced swim test (FST) paradigm were studied in male rats of the Wistar strain after acute intraperitoneal (i.p.) administration of 0.1, 0.5 or 1 mg/kg of the hormone. Melatonin at doses of 0.5 and 1 mg/kg, but not of 0.1 mg/kg, decreased the immobility of rats in the FST paradigm suggesting a possible antidepressant-like activity. The dose of 0.5 mg/kg appeared to be as potent as clomipramine 50 mg/kg in reducing the immobility time of rats in the FST paradigm. The effect of melatonin on immobility time of rats in the FST paradigm was abolished by the simultaneous injection of the non-selective melatonin antagonist, luzindole (0.25 mg/kg, subcutaneously). Similarly, administration of small quantities of serotonin (5-HT, 5 ng/1 mu l) or of the 5-HT2A/5HT(2C) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (2 ng/1 mu l) injected into the amygdale totally suppressed the reduction of immobility time in the FST paradigm induced by melatonin 0.5 mg/kg. These results may suggest that effects of melatonin on the behavioral reaction of rats in the FST paradigm are due to an interaction of the hormone with central 5-HT neurotransmission. (c) 2006 Elsevier B.V. and ECNP. All rights reserved.

Citovat

MICALE, Vincenzo; Anna AREZZI; Liborio RAMPELLO a Filippo DRAGO. Melatonin affects the immobility time of rats in the forced swim test: The role of serotonin neurotransmission. European Neuropsychopharmacology. Amsterdam (The Netherlands): Elsevier, 2006, roč. 16, č. 7, s. 538-545. ISSN 0924-977X. Dostupné z: https://doi.org/10.1016/j.euroneuro.2006.01.005.

@article{988768,
   author = {Micale, Vincenzo and Arezzi, Anna and Rampello, Liborio and Drago, Filippo},
   article_location = {Amsterdam (The Netherlands)},
   article_number = {7},
   doi = {https://doi.org/10.1016/j.euroneuro.2006.01.005},
   keywords = {melatonin; forced swim test; antidepressant activity; 5-HT; luzindole},
   language = {eng},
   issn = {0924-977X},
   journal = {European Neuropsychopharmacology},
   title = {Melatonin affects the immobility time of rats in the forced swim test: The role of serotonin neurotransmission},
   volume = {16},
   year = {2006}
}

TY  - JOUR
ID  - 988768
AU  - Micale, Vincenzo - Arezzi, Anna - Rampello, Liborio - Drago, Filippo
PY  - 2006
TI  - Melatonin affects the immobility time of rats in the forced swim test: The role of serotonin neurotransmission
JF  - European Neuropsychopharmacology
VL  - 16
IS  - 7
SP  - 538-545
EP  - 538-545
PB  - Elsevier
SN  - 0924977X
KW  - melatonin
KW  - forced swim test
KW  - antidepressant activity
KW  - 5-HT
KW  - luzindole
N2  - The efficacy of melatonin or its derivatives in depressive patients has been recently considered for clinical application. However, the evidence for its effect on experimental models of depression is not consolidated. Here, the effects of melatonin on the model of forced swim test (FST) paradigm were studied in male rats of the Wistar strain after acute intraperitoneal (i.p.) administration of 0.1, 0.5 or 1 mg/kg of the hormone. Melatonin at doses of 0.5 and 1 mg/kg, but not of 0.1 mg/kg, decreased the immobility of rats in the FST paradigm suggesting a possible antidepressant-like activity. The dose of 0.5 mg/kg appeared to be as potent as clomipramine 50 mg/kg in reducing the immobility time of rats in the FST paradigm. The effect of melatonin on immobility time of rats in the FST paradigm was abolished by the simultaneous injection of the non-selective melatonin antagonist, luzindole (0.25 mg/kg, subcutaneously). Similarly, administration of small quantities of serotonin (5-HT, 5 ng/1 mu l) or of the 5-HT2A/5HT(2C) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (2 ng/1 mu l) injected into the amygdale totally suppressed the reduction of immobility time in the FST paradigm induced by melatonin 0.5 mg/kg. These results may suggest that effects of melatonin on the behavioral reaction of rats in the FST paradigm are due to an interaction of the hormone with central 5-HT neurotransmission. (c) 2006 Elsevier B.V. and ECNP. All rights reserved.
ER  -

MICALE, Vincenzo; Anna AREZZI; Liborio RAMPELLO a Filippo DRAGO. Melatonin affects the immobility time of rats in the forced swim test: The role of serotonin neurotransmission. \textit{European Neuropsychopharmacology}. Amsterdam (The Netherlands): Elsevier, 2006, roč.~16, č.~7, s.~538-545. ISSN~0924-977X. Dostupné z: https://doi.org/10.1016/j.euroneuro.2006.01.005.

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