Long-lasting neurotoxicity of prenatal benzene acute exposure
in rats

J 2006

Long-lasting neurotoxicity of prenatal benzene acute exposure in rats

LO PUMO, Roberto; Marcello BELLIA; Annarita NICOSIA; Vincenzo MICALE; Filippo DRAGO et al.

Základní údaje

Originální název

Long-lasting neurotoxicity of prenatal benzene acute exposure in rats

Autoři

LO PUMO, Roberto; Marcello BELLIA; Annarita NICOSIA; Vincenzo MICALE a Filippo DRAGO

Vydání

Toxicology, Clare, Ireland, Elsevier Sci Ireland Ltd, 2006, 0300-483X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.685

Označené pro přenos do RIV

DOI

https://doi.org/10.1016/j.tox.2006.04.001

UT WoS

000238861900008

Klíčová slova anglicky

benzene; pregnancy; neonatal reflexes; conditioned avoidance; motor activity

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 8. 2012 07:58, Olga Křížová

Anotace

V originále

Benzene is a common element of environmental pollution. Although this substance is not recognized as a teratogenic agent, it is not known whether prenatal exposure to benzene may induce neurobehavioral changes in the progeny. Benzene 0.1 mg/kg was injected subcutaneously (s.c.) acutely at day 15 of gestation into pregnant female rats of the Sprague-Dawley strain and neurotoxicity of the substance was studied in pups and male adult animals of the same progeny. No change was found in total number of neonates, body weight and eye opening time between benzene-exposed animals and controls. No malformations were observed. At birth, neonatal reflexes (cliff aversion, forelimb placing, bar holding, forelimb grasping, startle) were scored in benzene-exposed pups and their percent appearance was found to be anticipated (more benzene-exposed pups exhibited reflexes each day) in comparison to that of control animals. Also, the completion (maximum appearance, i.e. 100% of the brood was found to exhibit each reflex) of neonatal reflexes in benzene-exposed animals preceded that of controls. Starting 2 months after birth, cognitive and motor performance was assessed only in male animals of the prenatally benzene-exposed progeny. The overall evaluation of motor activity in benzene-exposed animals in the open-field test revealed reduced ambulation in these rats as compared to control animals. Acquisition of active avoidance responses in the shuttle-box test, as assessed by the number of conditioned avoidance responses and the percent of learners, was impaired in benzene-exposed rats as compared to control animals. Prenatal exposure to benzene was also followed by reduced retention latency in a step-through passive avoidance task in two retention tests. These results suggest that acute exposure to benzene during gestational organogenesis may cause long-lasting changes in motor behavior and cognitive processes. This may be relevant for the assessment of benzene toxic profile for the progeny of pregnant subjects, although teratogenic effects are not observed. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

Citovat

LO PUMO, Roberto; Marcello BELLIA; Annarita NICOSIA; Vincenzo MICALE a Filippo DRAGO. Long-lasting neurotoxicity of prenatal benzene acute exposure in rats. Toxicology. Clare, Ireland: Elsevier Sci Ireland Ltd, 2006, roč. 223, č. 3, s. 227-234. ISSN 0300-483X. Dostupné z: https://doi.org/10.1016/j.tox.2006.04.001.

@article{988770,
   author = {Lo Pumo, Roberto and Bellia, Marcello and Nicosia, Annarita and Micale, Vincenzo and Drago, Filippo},
   article_location = {Clare, Ireland},
   article_number = {3},
   doi = {https://doi.org/10.1016/j.tox.2006.04.001},
   keywords = {benzene; pregnancy; neonatal reflexes; conditioned avoidance; motor activity},
   language = {eng},
   issn = {0300-483X},
   journal = {Toxicology},
   title = {Long-lasting neurotoxicity of prenatal benzene acute exposure in rats},
   volume = {223},
   year = {2006}
}

TY  - JOUR
ID  - 988770
AU  - Lo Pumo, Roberto - Bellia, Marcello - Nicosia, Annarita - Micale, Vincenzo - Drago, Filippo
PY  - 2006
TI  - Long-lasting neurotoxicity of prenatal benzene acute exposure in rats
JF  - Toxicology
VL  - 223
IS  - 3
SP  - 227-234
EP  - 227-234
PB  - Elsevier Sci Ireland Ltd
SN  - 0300483X
KW  - benzene
KW  - pregnancy
KW  - neonatal reflexes
KW  - conditioned avoidance
KW  - motor activity
N2  - Benzene is a common element of environmental pollution. Although this substance is not recognized as a teratogenic agent, it is not known whether prenatal exposure to benzene may induce neurobehavioral changes in the progeny. Benzene 0.1 mg/kg was injected subcutaneously (s.c.) acutely at day 15 of gestation into pregnant female rats of the Sprague-Dawley strain and neurotoxicity of the substance was studied in pups and male adult animals of the same progeny. No change was found in total number of neonates, body weight and eye opening time between benzene-exposed animals and controls. No malformations were observed. At birth, neonatal reflexes (cliff aversion, forelimb placing, bar holding, forelimb grasping, startle) were scored in benzene-exposed pups and their percent appearance was found to be anticipated (more benzene-exposed pups exhibited reflexes each day) in comparison to that of control animals. Also, the completion (maximum appearance, i.e. 100% of the brood was found to exhibit each reflex) of neonatal reflexes in benzene-exposed animals preceded that of controls. Starting 2 months after birth, cognitive and motor performance was assessed only in male animals of the prenatally benzene-exposed progeny. The overall evaluation of motor activity in benzene-exposed animals in the open-field test revealed reduced ambulation in these rats as compared to control animals. Acquisition of active avoidance responses in the shuttle-box test, as assessed by the number of conditioned avoidance responses and the percent of learners, was impaired in benzene-exposed rats as compared to control animals. Prenatal exposure to benzene was also followed by reduced retention latency in a step-through passive avoidance task in two retention tests. These results suggest that acute exposure to benzene during gestational organogenesis may cause long-lasting changes in motor behavior and cognitive processes. This may be relevant for the assessment of benzene toxic profile for the progeny of pregnant subjects, although teratogenic effects are not observed. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
ER  -

LO PUMO, Roberto; Marcello BELLIA; Annarita NICOSIA; Vincenzo MICALE a Filippo DRAGO. Long-lasting neurotoxicity of prenatal benzene acute exposure in rats. \textit{Toxicology}. Clare, Ireland: Elsevier Sci Ireland Ltd, 2006, roč.~223, č.~3, s.~227-234. ISSN~0300-483X. Dostupné z: https://doi.org/10.1016/j.tox.2006.04.001.

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