Behavioral effects of dietary cholesterol in rats tested in
experimental models of mild stress and cognition tasks

J 2008

Behavioral effects of dietary cholesterol in rats tested in experimental models of mild stress and cognition tasks

MICALE, Vincenzo; Giovanni SCAPAGNINI; Claudia COLOMBRITA; Carmen MAZZOLA; Daniel L ALKON et al.

Základní údaje

Originální název

Behavioral effects of dietary cholesterol in rats tested in experimental models of mild stress and cognition tasks

Autoři

MICALE, Vincenzo; Giovanni SCAPAGNINI; Claudia COLOMBRITA; Carmen MAZZOLA; Daniel L ALKON a Filippo DRAGO

Vydání

European Neuropsychopharmacology, Amsterdam (The Netherlands), Elsevier, 2008, 0924-977X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.661

Označené pro přenos do RIV

DOI

https://doi.org/10.1016/j.euroneuro.2007.11.006

UT WoS

000256323800009

Klíčová slova anglicky

cholesterol; forced swim test; antidepressant activity; memory; peripheral benzodiazepine receptor

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 8. 2012 08:15, Olga Křížová

Anotace

V originále

Abnormalities in serum cholesterol levels of patients with mood disorders have been identified in epidemiological studies. However, evidence for an influence of dietary cholesterol on behavioral models is poor. Here, we investigated the behavioral changes of Wistar mate rats fed a 2% cholesterol-enriched diet for 2 months in experimental models of depression and anxiety, such as the forced swim test (FST) paradigm and the novelty-induced grooming sampling test (NGT). The correlation between behavioral depression and impaired cognitive capacity was also examined testing rats in the Morris water maze (MWM) task one day after the FST. Different groups of rats fed various dietary regimens, were subjected to acute or repeated treatment (14 days) with clomipramine hydrochloride (50 or 25 mg/kg), diazepam (1 mg/kg) or with the peripheral benzodiazepine receptors (PBRs) antagonist, isoquinoline PK11195 (1 mg/kg) injected intraperitoneally (i.p.). Rats fed the cholesterol-enriched diet showed a significant decrease of grooming score in the NGT and of immobility time in the FST in comparison to animals fed a standard diet. Furthermore, the anxiolytic and antidepressant effects of diazepam and clomipramine were not affected by the different diets. Only after repeated treatment, PK11195 impaired the performance of animals fed a standard diet in the FST, and exhibited an anxiolytic-like profile in animals fed either the cholesterol-enriched or the standard diet. The improved performance in the FST was followed by a better learning performance in the acquisition phase of the MWM. These results suggest that effects of cholesterol-enriched diet on the behavioral reaction of rats in experimental models of mild stress may involve PBRs. They deserve attention in order to clarify the clinical correlation between plasma cholesterol levels and mood disorders in humans. (C) 2007 Elsevier B.V. and ECNR. All rights reserved.

Citovat

MICALE, Vincenzo; Giovanni SCAPAGNINI; Claudia COLOMBRITA; Carmen MAZZOLA; Daniel L ALKON a Filippo DRAGO. Behavioral effects of dietary cholesterol in rats tested in experimental models of mild stress and cognition tasks. European Neuropsychopharmacology. Amsterdam (The Netherlands): Elsevier, 2008, roč. 18, č. 6, s. 462-471. ISSN 0924-977X. Dostupné z: https://doi.org/10.1016/j.euroneuro.2007.11.006.

@article{988774,
   author = {Micale, Vincenzo and Scapagnini, Giovanni and Colombrita, Claudia and Mazzola, Carmen and Alkon, Daniel L and Drago, Filippo},
   article_location = {Amsterdam (The Netherlands)},
   article_number = {6},
   doi = {https://doi.org/10.1016/j.euroneuro.2007.11.006},
   keywords = {cholesterol; forced swim test; antidepressant activity; memory; peripheral benzodiazepine receptor},
   language = {eng},
   issn = {0924-977X},
   journal = {European Neuropsychopharmacology},
   title = {Behavioral effects of dietary cholesterol in rats tested in experimental models of mild stress and cognition tasks},
   volume = {18},
   year = {2008}
}

TY  - JOUR
ID  - 988774
AU  - Micale, Vincenzo - Scapagnini, Giovanni - Colombrita, Claudia - Mazzola, Carmen - Alkon, Daniel L - Drago, Filippo
PY  - 2008
TI  - Behavioral effects of dietary cholesterol in rats tested in experimental models of mild stress and cognition tasks
JF  - European Neuropsychopharmacology
VL  - 18
IS  - 6
SP  - 462-471
EP  - 462-471
PB  - Elsevier
SN  - 0924977X
KW  - cholesterol
KW  - forced swim test
KW  - antidepressant activity
KW  - memory
KW  - peripheral benzodiazepine receptor
N2  - Abnormalities in serum cholesterol levels of patients with mood disorders have been identified in epidemiological studies. However, evidence for an influence of dietary cholesterol on behavioral models is poor. Here, we investigated the behavioral changes of Wistar mate rats fed a 2% cholesterol-enriched diet for 2 months in experimental models of depression and anxiety, such as the forced swim test (FST) paradigm and the novelty-induced grooming sampling test (NGT). The correlation between behavioral depression and impaired cognitive capacity was also examined testing rats in the Morris water maze (MWM) task one day after the FST. Different groups of rats fed various dietary regimens, were subjected to acute or repeated treatment (14 days) with clomipramine hydrochloride (50 or 25 mg/kg), diazepam (1 mg/kg) or with the peripheral benzodiazepine receptors (PBRs) antagonist, isoquinoline PK11195 (1 mg/kg) injected intraperitoneally (i.p.). Rats fed the cholesterol-enriched diet showed a significant decrease of grooming score in the NGT and of immobility time in the FST in comparison to animals fed a standard diet. Furthermore, the anxiolytic and antidepressant effects of diazepam and clomipramine were not affected by the different diets. Only after repeated treatment, PK11195 impaired the performance of animals fed a standard diet in the FST, and exhibited an anxiolytic-like profile in animals fed either the cholesterol-enriched or the standard diet. The improved performance in the FST was followed by a better learning performance in the acquisition phase of the MWM. These results suggest that effects of cholesterol-enriched diet on the behavioral reaction of rats in experimental models of mild stress may involve PBRs. They deserve attention in order to clarify the clinical correlation between plasma cholesterol levels and mood disorders in humans. (C) 2007 Elsevier B.V. and ECNR. All rights reserved.
ER  -

MICALE, Vincenzo; Giovanni SCAPAGNINI; Claudia COLOMBRITA; Carmen MAZZOLA; Daniel L ALKON a Filippo DRAGO. Behavioral effects of dietary cholesterol in rats tested in experimental models of mild stress and cognition tasks. \textit{European Neuropsychopharmacology}. Amsterdam (The Netherlands): Elsevier, 2008, roč.~18, č.~6, s.~462-471. ISSN~0924-977X. Dostupné z: https://doi.org/10.1016/j.euroneuro.2007.11.006.

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