Cognitive effects of SL65.0155, a serotonin 5-HT4 receptor
partial agonist, in animal models of amnesia

J 2006

Cognitive effects of SL65.0155, a serotonin 5-HT4 receptor partial agonist, in animal models of amnesia

MICALE, Vincenzo; Gian Marco LEGGIO; Carmen MAZZOLA a Filippo DRAGO

Základní údaje

Originální název

Cognitive effects of SL65.0155, a serotonin 5-HT4 receptor partial agonist, in animal models of amnesia

Autoři

MICALE, Vincenzo; Gian Marco LEGGIO; Carmen MAZZOLA a Filippo DRAGO

Vydání

Brain Research, Amsterdam, Elsevier, 2006, 0006-8993

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.341

Označené pro přenos do RIV

DOI

https://doi.org/10.1016/j.brainres.2006.08.108

UT WoS

000242668400020

Klíčová slova anglicky

animal models of amnesia; serotonin 5-HT4 receptor; active and passive avoidance; radial maze test

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 8. 2012 08:18, Olga Křížová

Anotace

V originále

Given that several data suggest the involvement of serotonergic (5-HT) system, particularly the serotonin 5-HT4 receptors, in memory processes; this study was undertaken to investigate the role of serotonin 5-HT4 receptors in different experimental models of amnesia in male Swiss mice or in male Sprague-Dawley rats, tested in learning and memory tasks. Amnesia was induced in mice by intracerebroventricular (i.c.v.) injection of beta-amyloid 1-42 fragment (BAP 1-42; 400 pmol/mouse) or of galanin (GAL) 1-29 (3 mu g/mouse). Another group of animals was exposed to carbon monoxide (CO). Treatments were made 14 days, 15 min or 8 days prior to the learning trial of a step-through passive avoidance paradigm, respectively. Latency to re-enter the dark box appeared to be reduced in all treatment groups. Intraperitoneal (i.p.) administration of SL65.0155 (5-(8-amino-7-chloro-2,3-dihydro1,4-benzodioxin-5-yl)-3-[1-(2-phenylethyl)-4-piperidinyl] -1,3,4-oxadiazol-2 (3H) -one-monohydrochloride), a serotonin 5-HT4 receptor partial agonist (1 mg/kg/day), for 7 days prior to the learning trial, inhibited the amnesic effect of both peptides increasing the latency to re-enter the dark box also in mice exposed to CO. In rats with ibotenate-induced lesions of the nucleus basalis magnocellularis (NBM) or prenatally exposed to methylazoxymethanol (MAM), SL65.0155 (1 mg/kg/day, i.p.) administered for 7 days, improved the learning and memory capacity in animals tested in shuttle-box active avoidance and radial maze tests. These findings give further support to the hypothesis of SL65.0155 cognition-enhancing activity across a range of tasks. (c) 2006 Elsevier B.V. All rights reserved.

Citovat

MICALE, Vincenzo; Gian Marco LEGGIO; Carmen MAZZOLA a Filippo DRAGO. Cognitive effects of SL65.0155, a serotonin 5-HT4 receptor partial agonist, in animal models of amnesia. Brain Research. Amsterdam: Elsevier, 2006, roč. 1121, s. 207-215. ISSN 0006-8993. Dostupné z: https://doi.org/10.1016/j.brainres.2006.08.108.

@article{988775,
   author = {Micale, Vincenzo and Leggio, Gian Marco and Mazzola, Carmen and Drago, Filippo},
   article_location = {Amsterdam},
   doi = {https://doi.org/10.1016/j.brainres.2006.08.108},
   keywords = {animal models of amnesia; serotonin 5-HT4 receptor; active and passive avoidance; radial maze test},
   language = {eng},
   issn = {0006-8993},
   journal = {Brain Research},
   title = {Cognitive effects of SL65.0155, a serotonin 5-HT4 receptor partial agonist, in animal models of amnesia},
   volume = {1121},
   year = {2006}
}

TY  - JOUR
ID  - 988775
AU  - Micale, Vincenzo - Leggio, Gian Marco - Mazzola, Carmen - Drago, Filippo
PY  - 2006
TI  - Cognitive effects of SL65.0155, a serotonin 5-HT4 receptor partial agonist, in animal models of amnesia
JF  - Brain Research
VL  - 1121
SP  - 207-215
EP  - 207-215
PB  - Elsevier
SN  - 00068993
KW  - animal models of amnesia
KW  - serotonin 5-HT4 receptor
KW  - active and passive avoidance
KW  - radial maze test
N2  - Given that several data suggest the involvement of serotonergic (5-HT) system, particularly the serotonin 5-HT4 receptors, in memory processes; this study was undertaken to investigate the role of serotonin 5-HT4 receptors in different experimental models of amnesia in male Swiss mice or in male Sprague-Dawley rats, tested in learning and memory tasks. Amnesia was induced in mice by intracerebroventricular (i.c.v.) injection of beta-amyloid 1-42 fragment (BAP 1-42; 400 pmol/mouse) or of galanin (GAL) 1-29 (3 mu g/mouse). Another group of animals was exposed to carbon monoxide (CO). Treatments were made 14 days, 15 min or 8 days prior to the learning trial of a step-through passive avoidance paradigm, respectively. Latency to re-enter the dark box appeared to be reduced in all treatment groups. Intraperitoneal (i.p.) administration of SL65.0155 (5-(8-amino-7-chloro-2,3-dihydro1,4-benzodioxin-5-yl)-3-[1-(2-phenylethyl)-4-piperidinyl] -1,3,4-oxadiazol-2 (3H) -one-monohydrochloride), a serotonin 5-HT4 receptor partial agonist (1 mg/kg/day), for 7 days prior to the learning trial, inhibited the amnesic effect of both peptides increasing the latency to re-enter the dark box also in mice exposed to CO. In rats with ibotenate-induced lesions of the nucleus basalis magnocellularis (NBM) or prenatally exposed to methylazoxymethanol (MAM), SL65.0155 (1 mg/kg/day, i.p.) administered for 7 days, improved the learning and memory capacity in animals tested in shuttle-box active avoidance and radial maze tests. These findings give further support to the hypothesis of SL65.0155 cognition-enhancing activity across a range of tasks. (c) 2006 Elsevier B.V. All rights reserved.
ER  -

MICALE, Vincenzo; Gian Marco LEGGIO; Carmen MAZZOLA a Filippo DRAGO. Cognitive effects of SL65.0155, a serotonin 5-HT4 receptor partial agonist, in animal models of amnesia. \textit{Brain Research}. Amsterdam: Elsevier, 2006, roč.~1121, s.~207-215. ISSN~0006-8993. Dostupné z: https://doi.org/10.1016/j.brainres.2006.08.108.

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