Behavioral effects of saredutant, a tachykinin NK2 receptor
antagonist, in experimental models of mood disorders under
basal and stress-related conditions

J 2008

Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditions

MICALE, Vincenzo; Alessandra TAMBURELLA; Gian Marco LEGGIO; Carmen MAZZOLA; Valentina Li VOLSI et al.

Základní údaje

Originální název

Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditions

Autoři

MICALE, Vincenzo; Alessandra TAMBURELLA; Gian Marco LEGGIO; Carmen MAZZOLA; Valentina Li VOLSI a Filippo DRAGO

Vydání

Pharmacology Biochemistry and Behavior, OXFORD, Elsevier, 2008, 0091-3057

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.751

Označené pro přenos do RIV

DOI

https://doi.org/10.1016/j.pbb.2008.04.003

UT WoS

000257362700026

Klíčová slova anglicky

tachykinin NK2 receptor; elevated plus maze test; novelty-induced grooming sampling test; forced swim test; stress; saredutant

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 8. 2012 08:21, Olga Křížová

Anotace

V originále

The present study was made to investigate the role of tachyrkinin NK2 receptors in the expression of stress-related behaviors in animals. Under basal conditions, intraperitoneal (i.p.) administration of the selective tachykinin NK2 receptor antagonist, saredutant (1 and 3 mg/kg) or diazepam (1 mg/kg) exerted anxiolytic-like effects in rodents, as they reduced grooming score of Wistar male rats tested in the novelty-induced grooming sampling test (NGT) and increased percentage of time and entries in open arms of Swiss male mice tested in the elevated plus maze (EPM) test. After previous exposure to stress-related conditions, as induced by a 2-min forced swim made 5 min prior to the EPM test, saredutant but not diazepam, exhibited anxiolytic-like effects in mice. To study the antidepressant-like activity of tachykinin NK2 receptor antagonist under basal conditions, different groups of rats were injected i.p. with saredutant (2.5, 5 and 10 mg/kg) or the tricyclic antidepressant, clomipramine (50 mg/kg) and tested in the forced swim test (FST), a widely used antidepressant-responsive test. The influence of stress-related conditions was studied in rats subjected to electric foot-shocks (1 mA, 1 s) 24, 5 and 1 h prior to FST, after drugs injection. In the FST, clomipramine decreased the immobility time only under basal conditions, but not after application of acute foot-shocks. To the contrary, saredutant-treated rats also exhibited more active behavior in FST after previous exposure to stressors. These results give further support to the hypothesis that tachykinin NK2 receptors may be a therapeutic target for pharmacological treatment of stress-related diseases. such as anxiety and depression. (C) 2008 Elsevier Inc. All rights reserved.

Citovat

MICALE, Vincenzo; Alessandra TAMBURELLA; Gian Marco LEGGIO; Carmen MAZZOLA; Valentina Li VOLSI a Filippo DRAGO. Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditions. Pharmacology Biochemistry and Behavior. OXFORD: Elsevier, 2008, roč. 90, č. 3, s. 463-469. ISSN 0091-3057. Dostupné z: https://doi.org/10.1016/j.pbb.2008.04.003.

@article{988776,
   author = {Micale, Vincenzo and Tamburella, Alessandra and Leggio, Gian Marco and Mazzola, Carmen and Volsi, Valentina Li and Drago, Filippo},
   article_location = {OXFORD},
   article_number = {3},
   doi = {https://doi.org/10.1016/j.pbb.2008.04.003},
   keywords = {tachykinin NK2 receptor; elevated plus maze test; novelty-induced grooming sampling test; forced swim test; stress; saredutant},
   language = {eng},
   issn = {0091-3057},
   journal = {Pharmacology Biochemistry and Behavior},
   title = {Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditions},
   volume = {90},
   year = {2008}
}

TY  - JOUR
ID  - 988776
AU  - Micale, Vincenzo - Tamburella, Alessandra - Leggio, Gian Marco - Mazzola, Carmen - Volsi, Valentina Li - Drago, Filippo
PY  - 2008
TI  - Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditions
JF  - Pharmacology Biochemistry and Behavior
VL  - 90
IS  - 3
SP  - 463-469
EP  - 463-469
PB  - Elsevier
SN  - 00913057
KW  - tachykinin NK2 receptor
KW  - elevated plus maze test
KW  - novelty-induced grooming sampling test
KW  - forced swim test
KW  - stress
KW  - saredutant
N2  - The present study was made to investigate the role of tachyrkinin NK2 receptors in the expression of stress-related behaviors in animals. Under basal conditions, intraperitoneal (i.p.) administration of the selective tachykinin NK2 receptor antagonist, saredutant (1 and 3 mg/kg) or diazepam (1 mg/kg) exerted anxiolytic-like effects in rodents, as they reduced grooming score of Wistar male rats tested in the novelty-induced grooming sampling test (NGT) and increased percentage of time and entries in open arms of Swiss male mice tested in the elevated plus maze (EPM) test. After previous exposure to stress-related conditions, as induced by a 2-min forced swim made 5 min prior to the EPM test, saredutant but not diazepam, exhibited anxiolytic-like effects in mice. To study the antidepressant-like activity of tachykinin NK2 receptor antagonist under basal conditions, different groups of rats were injected i.p. with saredutant (2.5, 5 and 10 mg/kg) or the tricyclic antidepressant, clomipramine (50 mg/kg) and tested in the forced swim test (FST), a widely used antidepressant-responsive test. The influence of stress-related conditions was studied in rats subjected to electric foot-shocks (1 mA, 1 s) 24, 5 and 1 h prior to FST, after drugs injection. In the FST, clomipramine decreased the immobility time only under basal conditions, but not after application of acute foot-shocks. To the contrary, saredutant-treated rats also exhibited more active behavior in FST after previous exposure to stressors. These results give further support to the hypothesis that tachykinin NK2 receptors may be a therapeutic target for pharmacological treatment of stress-related diseases. such as anxiety and depression. (C) 2008 Elsevier Inc. All rights reserved.
ER  -

MICALE, Vincenzo; Alessandra TAMBURELLA; Gian Marco LEGGIO; Carmen MAZZOLA; Valentina Li VOLSI a Filippo DRAGO. Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditions. \textit{Pharmacology Biochemistry and Behavior}. OXFORD: Elsevier, 2008, roč.~90, č.~3, s.~463-469. ISSN~0091-3057. Dostupné z: https://doi.org/10.1016/j.pbb.2008.04.003.

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