In vitro vasculature models are interesting tools for research of vasculature hemodynamic minimizing a need for complicated animal models. To enable growth of cells in these models it is highly important to modify their surface with appropriate chemical and biochemical methods to achieve physiological study of endothelium layer.

Theoretical part of bachelor thesis will focus mainly on physiology of endothelium, the inner layer of vasculature, and vasculature pathology like aneurysms. The practical part will include 3D printing of vasculature models and surface modifications with materials to support an adhesion and a growth of endothelial cells. Cell survival will be characterized by viability tests such as MTT test and double staining.

Goals:
Creation of vasculature models from different materials which could be seeded with endothelial cells.