Subarachnoid hemorrhage (SAH) is a severe medical condition affecting around 8 out of 100 000 individuals per year. High mortality is caused either by the onset of bleeding initially or by subsequent complications such as re-bleeding, early brain injury (EBI), cerebral vasospasm (CVS), and delayed cerebral ischemia (DCI). Inflammation represents pathology which may contribute to all the SAH-related complications. One of the most studied inflammatory markers is Interleukin-6 (IL-6), which is associated with the severity of bleeding as well as with the final outcome. However, similarly to other pro-inflammatory cytokines, there is high interindividual variability in IL-6 levels. The goal of this thesis is to characterize the variability of IL-6 in the experimental model of SAH. The student will use a rat endovascular perforation model and basic laboratory methods. Timeline: 1st semester (2022): literature review, microsurgical technique training 2nd semester (2023): SAH model training, surgeries, sample collection, laboratory analyses. If necessary, modification of the experimental design (model switch) 3rd semester (2023): surgeries, sample collection, laboratory analyses, and evaluation. 4th semester (2024): final evaluation, thesis preparation, and defense