BLKLC011p Medical Chemistry-lecture

Faculty of Medicine
autumn 2019
Extent and Intensity
0/0/0. 4 credit(s). Type of Completion: zk (examination).
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. Jana Gregorová, Ph.D. (assistant)
MUDr. Miroslava Hlaváčová, Ph.D. (assistant)
PharmDr. Katarína Kostolanská (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
Lenka Nerudová (assistant)
Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Contact Person: Lenka Nerudová
Supplier department: Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students have knowledge that is necessary for understanding of chemical principles applied in further study subjects, especially in biochemistry.He/she understand solution properties and basic physico-chemical laws. Describes the properties of elements and inorganic compounds important for medicine, nutrition and toxicology. Discuses the structure of compounds and reactions taking part in metabolism and organic compounds that have importance in toxicology.
Learning outcomes
Students will be able to understand basics of general, inorganic and organic chemistry to the extent necessary for the further study of biochemistry.
They will be able to apply general physicochemical laws to processes in living organisms.
They will be able to describe the chemical properties of the most important biogenic elements and essential compounds of importance in medicine, nutrition and toxicology. They will be able to describe and discuss the properties and reactions of organic and bioorganic compounds important for the understanding of biochemical processes
  • Biochemistry for bacherols follows secondary school chemistry and broadens the subject considerably to the level required for the study of successive subjects. There are covered the basic principles of chemistry as well as the survey of biochemically important inorganic and organic compounds. A special attention is paid to the structures and chemistry of saccharides, lipids, steroids, aminoacids, proteins, nucleotides and nucleic acids. Biochemical part deals with the metabolism of nutrients including biochemistry of muscles and vision.
  • Atomic structure. Chemical bonds.
  • Latin nomenclature.
  • Chemical reactions. Basic chemical calculations.
  • Solutions. Acids and bases. Osmotic pressure.
  • Redox reactions. Adsorbents, detergents.
  • Biochemically important elements and their compounds.
  • Organic compounds. Hydrocarbons. Alcohols, phenols, ethers.
  • Carbonyl compounds. Carboxylic acids and their deivatives.
  • Nitrocompounds, amines, heterocycles and their biochemically important derivatives.
  • The chemistry of saccharides.
  • Aminoacids, peptides, proteins. Biocatalysis. Types of enzymes, enzyme nomenclature.
  • Lipids, phospholipids, glycolipids. Eicosanoids, steroids.
  • Nucleosides and nucleotides, types of nucleic acids.
  • Hemoproteins. Hem. Bile pigments.
  • General principles of metabolism. High-energy compounds. Citric acid cycle. Respiration chain, aerobic phosphorylation.
  • Saccharide metabolism, glycolysis, gluconeogenesis, synthesis of glycogen.
  • Metabolism of proteins and aminoacids. Proteins in food and their digestion. Synthesis of urea.
  • Digestion and resorption of lipids. Fatty acid metabolism, ketogenesis. Cholesterol.
  • Hormones, mechanism of their action. Neuron, neurotransmitters.
  • Muscle proteins, molecular principles of contraction and relaxation.
  • Metabolism of xenobiotics.
  • Biochemistry of vision, rhodopsine cycle. Metabolism of the cornea and the lens.
Teaching methods
teaching method is a lecture.
Assessment methods
The course is concluded by the oral examination. List of questions and other instructions you will find in the section Study materials of the course.
Language of instruction
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
Information on the extent and intensity of the course: 10.
The course is also listed under the following terms Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018.
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