BZBC011p Biochemistry and Hematology - lecture

Faculty of Medicine
autumn 2025
Extent and Intensity
2/0/0. 2 credit(s). Type of Completion: zk (examination).
In-person direct teaching
Teacher(s)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
Iva Audy (assistant)
doc. RNDr. Jiří Dostál, CSc. (assistant)
prof. RNDr. Eva Táborská, CSc. (assistant)
doc. RNDr. Josef Tomandl, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (alternate examiner)
Guaranteed by
Mgr. Jiří Slanina, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Jiří Slanina, Ph.D.
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Fri 19. 9. to Fri 21. 11. Fri 12:15–13:55 B22/116 aula, Fri 5. 12. to Fri 19. 12. Fri 12:15–13:55 B22/116 aula; and Fri 28. 11. 12:15–13:55 Kinosál N02901
Prerequisites
Admission to the exam is conditional upon successful completion of the course BZBC011c
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Abstract
Biochemistry for bacherols follows secondary school chemistry and biochemistry broadens the subject considerably to the level required for the study of successive subjects. The aim of the subject is to provide a comprehensive view of the basic metabolic processes in the human body related to the functioning of the human organism. It gets information on the production and use of energy in the human body, the structure and synthesis of the main molecules, the main regulatory mechanisms that maintain homeostasis. Students will obtain knowledge about the biochemical nature of the most important disorders of metabolism and bases of their clinico-biochemical examination, taking into account their specialization.
Learning outcomes
After the completion of the subject students will understand physicochemical processes important for biological systems, He can explain the basic principles of nutrient metabolism and the principles of regulation. Understands how energy is generated, used, and stored by the various organs of the body. Describes the biochemical processes typical for main organs and tissues in the body (heart, liver, kidney muscle, nerve tissue). He can explain the basic principles of homeostasis. He is familiar with the effects of major hormones and the principle of their action through receptors. Characterizes the composition and function of the main body fluids. Understand the processes of hemocoagulation.
Key topics
Basic terms. Solutions, concentration. Electrolytes. Osmotic pressure. Acids and bases, pH. Buffers. • Biogenic elements – overview, significance. Toxic elements. • Biochemically important organic substances. • Surfactants. • Saccharides-properties, classifications, overview. • Amino acids, peptides, proteins – properties, classification, overview. • Enzymes-structures, mechanism of enzymatic action, overview. Enzymes important in clinical biochemistry. • Lipides- properties, classifications, overview. Steroids-overview. Cholesterol, bile pigments. • Vitamins. • Nucleosides and nucleotides, basic types of nucleic acids. • Replication, transcription, translation. • Membranes, transport. • Metabolismus of nutrients-overview. Production of energy in cells. • Digestion and resorption of saccharides. Metabolism of saccharides. • Proteins in food, digestion, resorption. Metabolism of proteins and amino acids. • Digestion and resorption of lipids. Lipoproteins. Metabolism of lipids. Metabolism of cholesterol. • Metabolism under different states. • Biochemistry of blood. • Degradation of blood pigment. • Management of water and ions in the body. • Acid-base balance in organism. • Biochemical function of liver, and kidneys. Muscle tissue biochemistry. Connective tissue biochemistry. • Signal molecules and receptors. • Nerve cell. Nerve signal transmission. • Biochemistry of vision. Basic biochemical examination, factors influencing the results. Biological material - blood and urine, its collection and processing. Hemoglobin, carbonylhemoglobin, methemoglobin – poisoning. Diabetes mellitus. Determination of glucosemia. Biochemical diagnosis of myocardial infarction. Proof of alcohol in breath and blood. Metabolism of ethanol. Orientation analyses of urine by diagnostic strips. Drug tests.
Study resources and literature
Approaches, practices, and methods used in teaching
The course takes place in the form of lectures in the range 2 hours per week.
Method of verifying learning outcomes and course completion requirements
PC test on computers in the computer room of the Department of Biochemistry. Detailed information on the exam is given in IS MUNI (Study materials-Organization instructions).
Language of instruction
Czech
Further Comments
The course is taught annually.
The course is also listed under the following terms Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2023, autumn 2024.
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