VSLC011p Medical Chemistry - lecture

Faculty of Medicine
Autumn 2015
Extent and Intensity
2/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. MUDr. Vladimír Palyza, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
PharmDr. Lenka Adámková, Ph.D. (assistant)
RNDr. Hana Bochořáková (assistant)
Ing. Martina Čarnecká, Ph.D. (assistant)
Mgr. Jana Gregorová, Ph.D. (assistant)
MUDr. Miroslava Hlaváčová, Ph.D. (assistant)
Mgr. Jana Kantorová (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Milena Matejovičová, Ph.D. (assistant)
Ing. Jitka Melounová, Ph.D. (assistant)
Lenka Nerudová (assistant)
RNDr. Hana Paulová, CSc. (assistant)
Mgr. Ondřej Peš, Ph.D. (assistant)
Ing. Jana Simonová, Ph.D. (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
PharmDr. Kristýna Šebrlová, Ph.D. (assistant)
doc. RNDr. Josef Tomandl, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Supplier department: Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Graduate in chemistry has knowledge that is necessary for understanding of chemical principles applied in further study subjects, especially in biochemistry. He/she understands solution properties and basic physico-chemical laws. He/she is able to describe the properties of elements and inorganic compounds important for medicine, nutrition and toxicology. He/she discuss the structure of compounds and reactions taking part in metabolism and organic compounds that have importance in toxicology.
Syllabus
  • Information concerning medical chemistry. The basic chemical terms: substances, particles, amount of substance, some properties of a single particle and molar quantities. Electron configurations in atoms. Types of bonds, electronegativity. Non-covalent bonds and attraction forces.
  • Chemical reactions, kinetics, chemical equilibrium. The driving force of chemical reactions, free Gibbs energy.
  • Solutions of substances. Dissociation of electrolytes, the equilibria in electrolyte solutions.Precipitation reactions.
  • Protolytic reactions: acids and bases, pH values, hydrolysis of salts, buffers.
  • Oxidation-reduction reactions, redox potentials, the e.m. force of a voltaic cell and the relation to the reaction free energy change.
  • Essential macroelements important for living matter, general properties of them and of some of their compounds.
  • Carbon compounds: their constitution, configuration, isomerism, and conformation. Types of organic compounds, the principals of nomenclature. Hydrocarbons, major types, structures, reactivity.
  • Derivatives of hydrocarbons: alcohols, thioalcohols, phenols, carbonyl compounds, and carboxylic acids.
  • Substituted carboxylic acids and derivatives of the acids (esters, amides, anhydrides, halides).
  • Amines and the other derivatives of hydrocarbons.
  • Heterocyclic compounds and biochemically important derivatives. Alkaloids.
  • Structures and properties of monosaccharides. Simple sugar derivatives. Oligosaccharides, polysaccharides.
  • Heteroglycosides. Nucleosides, nucleotides, structures of nucleic acids.
  • Fatty acids and alcohols in lipids. Triacylglycerols and waxes. Phospholipids and glycolipids.
  • Icosanoids. Isoprenoids. Steroids, structures of representative compounds.
  • Standard and other alpha-amino acids, structures and common properties, polarity. Peptides, some groups of peptides exhibiting biological activity.
  • Proteins, main features of the structure of globular, fibrous, and membrane proteins. Glycoproteins. Haemoproteins, haem and other tetrapyrrols.
Literature
    required literature
  • TOMANDL, Josef, Jiří DOSTÁL, Hana PAULOVÁ and Eva TÁBORSKÁ. Základy lékařské chemie a biochemie. 1st ed. Brno: Masarykova Univerzita, 2014. 212 pp. ISBN 978-80-210-6973-2. info
  • Dostál J. (Ed.): Essentials of Medical Chemistry and Biochemistry http://portal.med.muni.cz/article-623-essentials-of-medical-chemistry-and-biochemistry.html
Teaching methods
Teaching form are lectures. Supplementary subjects are seminars and practicals (VSLC011c and VSLC011c).
Assessment methods
Student must have course-unit credit of seminar and practicals in the day of exam.
Examination from Medical chemistry is only written. The test consists from two parts. The first part is solved on computers in the computer room of Department of Biochemistry: calculations (concentration, pH, buffers, osmotic pressure) – see seminars simple questions (multiple choice or free answer) structural formulas (essential organic and inorganic compounds).
The second part is written and is focused on the active knowledge of structural formulas of the most important compounds, expression of important biochemical reactions by chemical equations and the ability to formulate the basic physico-chemical relationships or to draw graphs. For detailed instructions see Study materials - Information about exam.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
Information on the extent and intensity of the course: celkem 30 hodin.
The course is also listed under the following terms Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014.
  • Enrolment Statistics (recent)
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