aZLPF0622c Pathological Physiology II - practice

Faculty of Medicine
Spring 2018
Extent and Intensity
0/2/0. 3 credit(s). Type of Completion: z (credit).
Teacher(s)
prof. MUDr. Julie Dobrovolná, Ph.D. (seminar tutor)
prof. MUDr. Lydie Izakovičová Hollá, Ph.D. (seminar tutor)
MUDr. Michal Jurajda, Ph.D. (seminar tutor)
prof. MUDr. Kateřina Kaňková, Ph.D. (seminar tutor)
MUDr. Jan Máchal, Ph.D. (seminar tutor)
prof. RNDr. Michal Masařík, Ph.D. (seminar tutor)
Mgr. Lukáš Pácal, Ph.D. (seminar tutor)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (seminar tutor)
Věra Ježková (assistant)
Guaranteed by
prof. MUDr. Anna Vašků, CSc.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Anna Vašků, CSc.
Supplier department: Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Timetable
Mon 2. 4. to Fri 6. 4. each working day 7:30–10:00 A18/108
Prerequisites (in Czech)
aZLPF0521c Pathophysiol.I - practice
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The objective of the practical exercises and seminars from pathological physiology is to provide students basic idea about experimental work during pathological conditions (diseases).
Learning outcomes
Student will be able:
- to explain the pharmacological options affecting the secretion of gastric juice in the context of experimentally induced gastric ulcer in experimental animal model (inhibition of proton pump, H2 receptor blockade);
- to explain the pharmacological options affecting the secretion of gastric juice in the context of experimentally induced gastric ulcer in experimental animal model (inhibition of proton pump, H2 receptor blockade);
- to demonstrate the principle of load test (oGTT) in an animal model of experimentally induced diabetes (alloxan);
- to identify clinically relevant parameters describe nutritional status (calorimetry, BMI, WHR index, the weight, the skin-fold thickness, bioimpedance, DEXA) ;
- todemnostrate the examination of the quality of the skin barrier, through the examination of resistance and conductivity of the skin or a chemical (Burckhardt´s) examination with regard to the composition of the skin barrier;
- to demonstrate onset of obstruction icterus induced by ligation of ductus choledochus. He understands etiopathogenesis of other types of icterus (hemolytic, hepatic) and diagnostics of them using heme metabolites in urine, blood and stool using mitochondrial/cytoplasmatic membranes liver enzymes;
- to describe etiopathogenesis of venous thrombosis using data from experimental animal model;
- to explain the importance and principles of DNA d iagnostics to detect I/D polymorphism using PCR methodology ACE
Syllabus
  • Practical excercises:
  • 1. Exp. induced peptic ulcer – quantification of gastric juice secretion in lab. animal
  • 2. Anaphylactic reaction (seminar)
  • 3. Statistical evaluations of experiments (advanced methods)
  • 4. Endocrinology (seminar)
  • 5. Use of enzyme (and other) markers in diagnostics of selected pathophysiological states – evaluation of LDH isoenzymes
  • 6. Exp. induced vein thrombosis in lab. animal
  • 7. Exp. induced diabetes mellitus – diagnosis by glucose tolerance test
  • 8. Eating disorders (seminar)
  • 9. Exp. induced haemolytic, hepatotoxic and obstruction jaundice in lab. animal
  • 10. Neuropathophysiology+ credits
Literature
Teaching methods
Practical training.
Assessment methods
Credit. Practical exercises are compulsory (absence can be excused only in case of sick leave). During the term, tutors can continuously test knowledge in written tests or students can be asked to elaborate special papers.Term tuition (blocks) is completed by credit, conditions for awarding credit are: i) participation in the practical exercises, ii) elaboration of protocols from experimental practical exercises, iii) further individually chosen tutor's criteria.
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.
  • Enrolment Statistics (Spring 2018, recent)
  • Permalink: https://is.muni.cz/course/med/spring2018/aZLPF0622c