aZLPF0521c Pathological Physiology I - practice

Faculty of Medicine
autumn 2023
Extent and Intensity
0/2/0. 2 credit(s). Type of Completion: z (credit).
Taught in person.
RNDr. Jan Balvan, Ph.D. (seminar tutor)
MUDr. Vendula Bartáková, Ph.D. (seminar tutor)
MUDr. Kamil Ďuriš, Ph.D. (seminar tutor)
doc. MUDr. Jaromír Gumulec, Ph.D. (seminar tutor)
MUDr. Michal Jurajda, Ph.D. (seminar tutor)
MUDr. Jan Máchal, Ph.D. (seminar tutor)
prof. RNDr. Michal Masařík, Ph.D. (seminar tutor)
Mgr. Lukáš Pácal, Ph.D. (seminar tutor)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (seminar tutor), prof. MUDr. Julie Dobrovolná, Ph.D. (deputy)
prof. MUDr. Anna Vašků, CSc. (seminar tutor)
Bc. Lenka Hladíková (assistant)
Guaranteed by
prof. MUDr. Anna Vašků, CSc.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Anna Vašků, CSc.
Supplier department: Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Mon 30. 10. 7:00–12:20 A18/205, Tue 31. 10. 7:00–12:20 A18/205, Wed 1. 11. 7:00–12:20 A18/205, Thu 2. 11. 7:00–12:20 A18/205, Fri 3. 11. 7:00–12:20 A18/205
aZLFY0422p Physiology II - lecture && ( aZLBC041c Biochemistry II - pract. || aZLBC0422c Biochemistry II - practice ) && ( aZLBC041s Biochemistry II sem || aZLBC0422s Biochemistry II seminar )&& ( aZLAN0222s Anatomy II - sem. || aZLAN0333s Anatomy III - seminar ) && ( aZLAN0222c Anatomy II - dissection || aZLAN0333c Anatomy III-dissect. ) && aZLHE0322c Histology and Embryol.II -prac && aZLLT0222s Bas.Med.Terminology II -sem.
Physiology, biochemistry
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The objective of the practical exercises and seminars from pathological physiology is to provide students basic idea about pathological states and experimental work. Students will also acquire practical skills necessary for their subsequent (future) study and work.
Learning outcomes
Student characterizes state of healthy and disease
Student calls main sources of interindividual variability
Student demonstrates understanding of an influence of external factors on disease development, especially in oral cavity
Student characterizes base features of complex diseases
Student summarises importance of epigenetics
Student describes pathophysiology of stress reaction
Student defines homeostasis term
Student identifies disorder of growth and development from ontogenetic point of view
Student describes results of hypoxia including HIF 1 program
Student explains a difference between local and systemic inflammation
Student explains pathogenesis of oedema
Student discusses etiopathogenesis of the most important ion homeostasis disturbances, especially those of Ca++, Mg++ and K+
Student distinguishes base acid base balance disturbances and possibilities of their compensation
Student applies knowledge of volume and tonicity regulation
Student discusses a role of platelets and physiological endothelium during antiaggregation state and understands base principles of antiaggregation therapy
Student knows principles and performance of base coagulation tests
Student explains wound healing process with examples of pathological healing, especially in oral cavity
Student explains an importance of micronutrients abnormalities, especially considering oral cavity state
Student knows results of abnormal vitamin levels, especially in oral cavity
Student explains mechanism of genomic and non- genomic effects of soluble in lipids vitamins
Student discusses pathophysiology of protein metabolism
Student understands the base principles of regulation of glucose
Student interprets knowledge of immune recognition of own and foreign structure on examples of specifically organ and systemic disorders
Student interprets immunological knowledge of hypersensitive mechanisms in pathophysiology of atopic and allergic changes
Student describes onset, signs and results of heart and vessels remodelling
Student applies chronobiology knowledge for explication of different pathophysiological changes
  • Pathophysiology of ventilation disorders and pulmonary gas exchange – spirometry.
  • Cell cycle, oncogenes and supressor genes, cancer development.
  • Essential hypertension (seminar), resting and ambulatory blood pressure (and heart rate) measurements, postural changes, effect of isometric and aerobic exercise.
  • Secondary hypertension (seminar), exp. induced renal ischemia (quantification of renal renin expression).
  • Atherosclerosis (seminar), principles and demonstration of peripheral blood flow examination using ultrasonography.
  • Exp. induced acute renal insufficiency in lab. animal – measurement of GFR based on kinetics of renal inulin excretion.
  • Statistical analysis of experiments (introduction).
  • Exp. induced acute radiation syndrome in lab. animal – haematological consequences.
  • Arrhytmias (seminar), demonstration of selected types of arrhythmias.
  • Acid-base balance, Credits.
Teaching methods
practical training
Assessment methods
Credit. Practical exercises are compulsory (one absence cen be tellerated, another ones can be excused only in case of sick leave). During the term, tutors can continuously test knowledge in written tests or students can be asked to elaborate special papers.Term tuition (blocks) is completed by credit, conditions for awarding credit are: i) participation in the practical exercises, ii) further individually chosen tutor's criteria.
Language of instruction
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
General note: Studenti opakující 3. ročník nemusejí znovu absolvovat praktika, budou jim uznány zápočty, ke zkoušce mohou přijít v nejbližším zkouškovém období.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses

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Teacher's information
Students have to follow the safety rules during the practicals. Student can - with tutor's approval - substitute the particular practical with another group in case he/she has a justifiable reason for it.
The course is also listed under the following terms Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2022.
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