aZLBC0422s Biochemistry II seminar

Faculty of Medicine
spring 2024
Extent and Intensity
0/2/0. 1 credit(s). Type of Completion: z (credit).
Taught in person.
doc. RNDr. Jiří Dostál, CSc. (seminar tutor)
doc. RNDr. Josef Tomandl, Ph.D. (seminar tutor)
Mgr. Jana Gregorová, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (assistant)
doc. Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
Bc. Ivana Ševčíková (assistant)
prof. RNDr. Eva Táborská, CSc. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Contact Person: RNDr. Hana Paulová, CSc.
Supplier department: Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Prerequisites (in Czech)
aZLLC011p Med Chem, Dental Mat - lect && aZLBF011p Med.Physics and Informat.-lect && aZLBI0222p Biology II-lect. && ( aZLBC0221s Biochemistry I - seminar || aZLBC0321s Biochemistry I - seminar )
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Seminars are complementary to the Biochemistry lecture (aZLBC041p). The knowledge of intermediary metabolism, characteristic features of metabolism of individual organs and tissues and metabolism at various conditions of the organism (well-fed state, fasting, starvation, metabolic stress, obesity, metabolic syndrome)are thoroughly practiced during Biochemistry seminars.
Learning outcomes
The student will be able to:
- explain the interrelationship between the metabolism of nutrients under different states of the organism.
- describe the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases.
- understand and discuss principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations
- discuss the composition of body fluids and their disorders in connection with the principles of homeostasis.
- explain the principles of metabolism regulation at all levels.
  • Factors affecting results and interpretation of examinations. Enzymes in clinical diagnostics.
  • Blood glucose. Diabetes mellitus.
  • Plasma lipoproteins, interconversion. Cholesterol transport and balance.
  • Protein and amino acid transformations, transport of ammonia. Proteins in nutrition.
  • Integration of nutrient metabolism in various states and during stress. Metabolic syndrome.
  • Liver functions, role in metabolism of nutrients, hormones, and vitamins. Catabolism of heme, hyperbilirubinemias.
  • Water and mineral metabolism. Sodium and water homeostasis, osmolality and volemia.
  • Acid-base balance, parameters, regulation, disorders. Buffer bases. Transport of O2 and CO2.
  • Major functions of kidneys. Glomerular filtration. Tubular resorption and secretion.
  • Biotransformation of xenobiotics. Metabolism of alcohol.
  • Receptors and signal transduction.
  • Metabolism of Ca, P and F. Composition and metabolism of bones and teeth.
  • Saliva biochemistry. Influence of nutrition on oral health.
    required literature
  • Study materials for the course Biochemistry II in IS MUNI.
  • FERRIER, Denise R. Biochemistry. Seventh edition. Philadelphia: Wolters Kluwer, 2017. viii, 567. ISBN 9781496363541. info
    recommended literature
  • VASUDEVAN, D. M., S. SREEKUMARI and Kannan VAIDYANATHAN. Textbook of biochemistry for dental students. 3rd edition. New Delhi: Jaypee, 2017. xiii, 289. ISBN 9789352701148. info
Teaching methods
Seminary course. Class discussions on assigned topics.
Assessment methods
Course-unit credit.
Conditions for giving the course-unit credit (all conditions should be met):
  • completion of all lessons, missed lessons must be made up,
  • minimal success rate of 70 % from the sum of all revision tests or minimal success rate of 50 % from the credit test. The resit credit test can be taken only once.
    The detailed conditions are posted in IS MUNI (Study materials – Course-related instructions).
  • Language of instruction
    Further comments (probably available only in Czech)
    The course is taught annually.
    The course is taught: every week.
    General note: Successful completion of the course is a condition for access to the exam in the course aZLBC0422p.
    Information on the extent and intensity of the course: 30.
    Listed among pre-requisites of other courses

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    Teacher's information
    Information to seminars, the conditions for giving the course-unit credit and the syllabus are available in the IS MUNI in the Course-related instructions. The syllabus is also posted on the notice board of the Department of Biochemistry.
    Consultations are possible after a personal arrangement with the teacher.
    Successful completion of the course is a condition for access to the exam in the course aZLBC0422p.
    The course is also listed under the following terms spring 2021, spring 2022, spring 2023.
    • Enrolment Statistics (spring 2024, recent)
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