aZLBC0321s Biochemistry I - seminar

Faculty of Medicine
autumn 2022
Extent and Intensity
0/2/0. 3 credit(s). Type of Completion: z (credit).
Taught in person.
doc. RNDr. Josef Tomandl, Ph.D. (seminar tutor)
doc. RNDr. Jiří Dostál, CSc. (assistant)
Mgr. Jana Gregorová, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (assistant)
Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
Bc. Ivana Ševčíková (assistant)
prof. RNDr. Eva Táborská, CSc. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Supplier department: Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Wed 12:00–13:40 A16/213
Prerequisites (in Czech)
aZLLC011p Med Chem, Dental Mat - lect && aZLBF011p Med.Physics and Informat.-lect && aZLBI0222p Biology II-lect.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Seminars are complementary to Biochemistry I lecture (ZLBC0221p). At the end of the course student understand and can describe the major metabolic pathways and their significance.
Learning outcomes
In the end of the course students will able to:
  • understand the properties and function of enzymes.
  • describe basic catabolic and anabolic pathways of carbohydrate, lipid and protein metabolism.
  • understand the principles of energy production, utilization and deposition at the cellular level.
  • explain the function of cell membranes, the principle of compartmentalization at the cellular level, and the transport processes on the membrane.
  • describe protein synthesis, starting with the replication and transcription, translation and post-translational modifications.
  • understand the relationship between protein structure and function.
  • explain the function of hemoglobin in oxygen transport and maintaining acid-base balance.
  • discuss the principles of some diseases at the molecular level.
  • Syllabus
    • Introduction into the metabolism of cells (differences between prokatyotic and eukaryotic cell).
    • Membrane structure and assembly. Transport across membranes.
    • Structure of haemoglobin and its relationship to the function. Hb types in the blood of healthy subjects, HbCO and MetHb, abnormal Hb types.
    • Enzymes - reaction rate, progress curve, the Michaelis plot and Michaelis constant, enzyme inhibition.
    • Coenzymes, their relationship to vitamins.
    • The citric acid cycle. The respiratory chain and oxidative phosphorylation.
    • Digestion of saccharides. Metabolism of glucose - glycolysis, gluconeogenesis. Glycogenesis and glycogenolysis.
    • Digestion of proteins. Metabolism of proteins. Common features of amino acid conversion. The synthesis of urea. Nitrogen balance.
    • Important reactions in amino acid catabolism. li>Digestion of lipids. Biosynthesis and desaturation of fatty acids. Ketogenesis. Synthesis of triacylglycerols.
    • Desaturation of fatty acids. Metabolism of phospholipids. Metabolism of cholesterol and bile acids.
    • Replication, transcription.
      required literature
    • Seminar texts available in Information system
    • FERRIER, Denise R. Biochemistry. Seventh edition. Philadelphia: Wolters Kluwer, 2017. viii, 567. ISBN 9781496363541. info
      recommended literature
    • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Color atlas of biochemistry. 3rd ed., rev. and updated. Stuttgart: Thieme, 2013. ix, 495. ISBN 9783131696939. info
    • LIEBERMAN, Michael, Allan D. MARKS and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013. ix, 1014. ISBN 9781451100037. info
    • VASUDEVAN, D. M., S. SREEKUMARI and Kannan VAIDYANATHAN. Textbook of biochemistry for dental students. 3rd edition. New Delhi: Jaypee, 2017. xiii, 289. ISBN 9789352701148. info
    Teaching methods
    Seminar. The course is based on group discussion on the given topics. The outlines of the discussion are in the recommended textbook. Complementary materials are available in section Study materials.
    Assessment methods
    Course-unit credit. Conditions for giving the course-unit credit (both conditions should be met):
  • Full attendance in lessons. All absences should be justified and then made up.
  • At least 70% success rate from partial revision tests or 50% success rate in credit test, the resit credit test can be taken only once.
    The detailed conditions are posted in Information System (Study materials – Course-related instructions).
  • Language of instruction
    Further comments (probably available only in Czech)
    The course is taught annually.
    Information on the extent and intensity of the course: 30.
    Listed among pre-requisites of other courses
    The course is also listed under the following terms autumn 2020, autumn 2021.
    • Enrolment Statistics (recent)
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