aZLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2021
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
Taught online.
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. Jana Gregorová, Ph.D. (assistant)
MUDr. Miroslava Hlaváčová, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Supplier department: Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Timetable
Mon 10:00–10:50 A21/108
Prerequisites (in Czech)
aZLLC011p Medical Chemistry,DM - lecture && aZLBF011p Med.Physics and Informat.-lect && aZLBI0222p Biology II-lect. && ( aZLBC0221s Biochemistry I - seminar || aZLBC0321s Biochemistry I - seminar )
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with the integration of biochemical processes in the human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. Special attention is focused on biochemical processes in oral cavity and biochemical aspects of dental tissues.
Learning outcomes
The student is able to:
- explain the interrelationship between the metabolism of nutrients under different states of the organism.
- describe the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases.
- understand and discuss principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations
- discuss the composition of body fluids and their disorders in connection with the principles of homeostasis.
- explain the principles of metabolism regulation at all levels.
Syllabus
  • Digestion and absorption of lipids. Blood plasma lipids and the major groups of lipoproteins. Metabolic fate of chylomicrons and VLDL, the metabolism of HDL.
  • The integration of intermediary metabolism at the tissue and organ level (after the meal, during starvation, stress, obesity).
  • The metabolic functions of the liver. Catabolism of haemoglobin, bilirubin metabolism. Metabolism of iron.
  • Biotransformation of xenobiotics. Two phases of biotransformation, typical reactions, cytochrome P450. Metabolism of ethanol.
  • Control of metabolism. Mechanism of hormone and neurotransmitter action. Types of membrane receptors, intracellular receptors.
  • Nerve cells. Neuro-secretion. The biosynthesis and inactivation of neurotransmitters, neurotransmission across synapses. Cholinergic, adrenergic, gabaergic receptors.
  • Body water, the movement of water between ECF and ICF, water excretion. Ionic composition of blood plasma, gradients of Na+ and K+ across cell membranes. Plasma osmolality, oncotic pressure. Regulation of Na+ a K+ excretion.
  • Transport of O2 and CO2. Metabolic pathways producing/consuming H+ ions. Buffer bases of blood, blood plasma (concentrations of components), ICF, the parameters of acid-base status. The role of the lung, the kidney, and the liver in maintaining acid-base balance.
  • Normal renal functions. Glomerular filtration. Tubular resorption and secretion.
  • Metabolism of calcium, magnesium, phosphates, fluoride, and iodine. Hormones involved in their metabolism.
  • The extracellular matrix. Mineralisation of hard tissues, regulation. Composition of bones, dentine, enamel, and cement.
  • Saliva and biochemical aspects of oral homeostasis. Plaque formation and metabolism. Influence of nutrition on oral health.
  • The major proteins of blood plasma. The blood-coagulation cascade, inhibition of clotting. Fibrinogen, fibrin, fibrinolysis.
  • Endothelial cells. Biochemistry of blood cells.
Literature
    recommended literature
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Color atlas of biochemistry. 3rd ed., rev. and updated. Stuttgart: Thieme, 2013. ix, 495. ISBN 9783131696939. info
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harper's Illustrated Biochemistry. 28th ed. McGraw-Hill, 2009. ISBN 978-0-07-163827-2. info
Teaching methods
Teaching forms are online lectures. Supplementary subjects are seminars and practicals (ZLBC041c and ZLBC041c).
Assessment methods (in Czech)
The course of Biochemistry II (aZLBC0422p) is completed by an exam. Obtaining course-unit credits of practices (aZLBC0422c) and seminars (aZLBC0422s) is the pre-requisite for registration to the examination of Biochemistry II. The examination has only an oral part. The official list of examination questions will be published in the Study materials of aZLBC041p. Three questions will be randomly selected from the three parts of the list. There will be no preparation time before the oral exam. Students are supposed to summarize the substantial and relevant issues. Examiners may ask additional questions. If appropriate, students may use paper and a pen.
Language of instruction
English
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 15.
Information on course enrolment limitations: Přihlášení ke zkoušce je podmíněno vykonáním zkoušky z Biochemie I.
Listed among pre-requisites of other courses

  • Enrolment Statistics (recent)
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