aZLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2024
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
Taught in person.
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. Jana Gregorová, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
doc. Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Mon 11:00–11:50 A16/308
Prerequisites (in Czech)
aZLLC011p Med Chem, Dental Mat - lect && aZLBF011p Med.Physics and Informat.-lect && aZLBI0222p Biology II-lect. && ( aZLBC0221s Biochemistry I - seminar || aZLBC0321s Biochemistry I - seminar )
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with the integration of biochemical processes in the human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. Special attention is focused on biochemical processes in oral cavity and biochemical aspects of dental tissues.
Learning outcomes
The student will be able to:
- explain the interrelationship between the metabolism of nutrients under different states of the organism.
- describe the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases.
- understand and discuss principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations
- discuss the composition of body fluids and their disorders in connection with the principles of homeostasis.
- explain the principles of metabolism regulation at all levels.
  • Blood plasma lipids. Lipoprotein metabolism.
  • Integration of intermediary metabolism at tissue and organ level under various conditions.
  • Metabolic functions of liver. Catabolism of haemoglobin. Metabolism of iron.
  • Biotransformation of xenobiotics, cytochromes P450. Metabolism of ethanol.
  • Homeostasis of water and Na+, K+ ions, plasma osmolality, volemia.
  • Acid-base balance. Transport of O2 and CO2. Buffer bases, parameters of acid-base status.
  • Biochemical functions of kidney. Glomerular filtration. Tubular resorption and secretion.
  • Control of metabolism. Common mechanisms of action of signal molecules.
  • Nervous tissue. Neurosecretion. Neurotransmitters, processes at synapses.
  • Metabolism of calcium, magnesium, phosphates, fluorine, and iodine.
  • Extracellular matrix. Hard tissues, mineralization.
  • Saliva and oral homeostasis. Tooth plaque. Influence of nutrition on oral health.
  • Vascular endothelium. Biochemistry of blood elements. Basics of immunochemistry.
  • Blood plasma proteins. Coagulation cascade, fibrinolysis.
    required literature
  • FERRIER, Denise R. Biochemistry. Seventh edition. Philadelphia: Wolters Kluwer, 2017. viii, 567. ISBN 9781496363541. info
  • Study materials for the course Biochemistry II in IS MUNI.
    recommended literature
  • LIEBERMAN, Michael, Allan D. MARKS and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013. ix, 1014. ISBN 9781451100037. info
  • Recommended literature from medical physiology in the course aZLFY0422p.
  • VASUDEVAN, D. M., S. SREEKUMARI and Kannan VAIDYANATHAN. Textbook of biochemistry for dental students. 3rd edition. New Delhi: Jaypee, 2017. xiii, 289. ISBN 9789352701148. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Color atlas of biochemistry. 3rd ed., rev. and updated. Stuttgart: Thieme, 2013. ix, 495. ISBN 9783131003737. info
Teaching methods
Assessment methods
Oral exam. The student will randomly draw two questions from Biochemistry I and two questions from Biochemistry II. The student answers without preparation.
Language of instruction
Further comments (probably available only in Czech)
Information on completion of the course: Admission to the exam is conditioned by obtaining a credit of the courses: aZLBC0422s and aZLBC0422c.
The course is taught annually.
Information on the extent and intensity of the course: 15.
Listed among pre-requisites of other courses
Teacher's information
The basic concepts and topics included in the Biochemistry II exam are available in the Course-Related Instructions in IS MUNI.
The course is also listed under the following terms spring 2021, spring 2022, spring 2023.
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