aZLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2023
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
Taught in person.
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. Jana Gregorová, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
Bc. Ivana Ševčíková (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (alternate examiner)
Mgr. Jiří Slanina, Ph.D. (alternate examiner)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Supplier department: Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Prerequisites (in Czech)
aZLLC011p Med Chem, Dental Mat - lect && aZLBF011p Med.Physics and Informat.-lect && aZLBI0222p Biology II-lect. && ( aZLBC0221s Biochemistry I - seminar || aZLBC0321s Biochemistry I - seminar )
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with the integration of biochemical processes in the human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. Special attention is focused on biochemical processes in oral cavity and biochemical aspects of dental tissues.
Learning outcomes
The student is able to:
- explain the interrelationship between the metabolism of nutrients under different states of the organism.
- describe the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases.
- understand and discuss principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations
- discuss the composition of body fluids and their disorders in connection with the principles of homeostasis.
- explain the principles of metabolism regulation at all levels.
Syllabus
  • Plasma lipids. Lipoprotein metabolism.
  • Nutrient metabolism in different conditions.
  • Biochemical functions of the liver. Iron metabolism. Heme catabolism.
  • Membrane and intracellular receptors. General mechanisms of action of hormones and neurotransmitters.
  • Nervous tissue metabolism. Neurotransmitters, synapses.
  • Homeostasis of water, Na + and K  + ions. Regulation of osmolality and volemia.
  • Acid-base balance. Transport O  2 and CO 2 through blood. Buffer bases.
  • Biochemical functions of the kidneys. Renal filtration function. Tubular resorption and secretion.
  • Metabolism of calcium, magnesium, phosphates, fluorine and iodine.
  • Extracellular matrix. Bone metabolism, calcification of bones, dentin, enamel and cement.
  • Saliva and biochemical aspects of oral homeostasis. Plaque metabolism. The effect of diet on the condition of the oral cavity and teeth.
  • Major proteins of blood plasma. Haemocoagulation, fibrinolysis.
  • Vascular endothelium. Biochemistry of blood elements.
Literature
    required literature
  • FERRIER, Denise R. Biochemistry. Seventh edition. Philadelphia: Wolters Kluwer, 2017. viii, 567. ISBN 9781496363541. info
  • Supplementary materials: https://is.muni.cz/auth/el/med/jaro2022/aZLBC0422s/um/
    recommended literature
  • LIEBERMAN, Michael, Allan D. MARKS and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013. ix, 1014. ISBN 9781451100037. info
  • HALL, John E. and Arthur C. GUYTON. Guyton and Hall textbook of medical physiology. 12th ed. Philadelphia, Pa.: Saunders/Elsevier, 2011. xix, 1091. ISBN 9781416045748. info
  • COSTANZO, Linda S. Physiology. Seventh edition. Philadelphia, PA: Elsevier, 2022. x, 518. ISBN 9780323793339. info
  • VASUDEVAN, D. M., S. SREEKUMARI and Kannan VAIDYANATHAN. Textbook of biochemistry for dental students. 3rd edition. New Delhi: Jaypee, 2017. xiii, 289. ISBN 9789352701148. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Color atlas of biochemistry. 3rd ed., rev. and updated. Stuttgart: Thieme, 2013. ix, 495. ISBN 9783131696939. info
Teaching methods
Lectures
Assessment methods
Oral exam - students will draw three questions from Biochemistry I and Biochemistry II.
Language of instruction
English
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
Information on the extent and intensity of the course: 15.
Listed among pre-requisites of other courses
Teacher's information
https://is.muni.cz/auth/el/1411/jaro2022/aZLBC0422p/
The basic concepts and topics included in the Biochemistry II exam are available in the Course-Related Instructions in IS MUNI.
The course is also listed under the following terms spring 2021, spring 2022.
  • Enrolment Statistics (spring 2023, recent)
  • Permalink: https://is.muni.cz/course/med/spring2023/aZLBC0422p