aZLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2026
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
In-person direct teaching
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. Marie Tomandlová, Ph.D. (lecturer)
Iva Audy (assistant)
Mgr. Jana Gregorová, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
doc. Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Prerequisites (in Czech)
aZLLC011p Med Chem, Dental Mat - lect && aZLBF011p Med.Physics and Informat.-lect && aZLBI0222p Biology II-lect. && ( aZLBC0221s Biochemistry I - seminar || aZLBC0321s Biochemistry I - seminar )
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with the integration of biochemical processes in the human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. Special attention is focused on biochemical processes in oral cavity and biochemical aspects of dental tissues.
Learning outcomes
The student will be able to:
- explain the interrelationship between the metabolism of nutrients under different states of the organism.
- describe the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases.
- understand and discuss principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations
- discuss the composition of body fluids and their disorders in connection with the principles of homeostasis.
- explain the principles of metabolism regulation at all levels.
Syllabus
  • Blood plasma lipids. Lipoprotein transformations.
  • Nutrient metabolism in various states.
  • Biochemical functions of the liver, role in iron metabolism.
  • Heme catabolism.
  • Biotransformation of xenobiotics, cytochromes P450. Metabolism of ethanol.
  • Homeostasis of water, Na+ and K+. Plasma osmolality.
  • Acid-base balance, buffer systems. Transport of O2 and CO2 in blood.
  • Kidney function in homeostasis.
  • Regulation of metabolism. General mechanisms of cell signalling.
  • Biochemistry of nervous tissue, processes at synapses.
  • Metabolism of calcium, phosphorus, fluorine.
  • Extracellular matrix. Hard tissues, mineralization.
  • Saliva and oral homeostasis, the influence of diet. Dental plaque.
  • Vascular endothelium. Hemocoagulation, anticoagulation mechanisms.
  • Biochemistry of blood elements. Blood plasma proteins.
Literature
    required literature
  • FERRIER, Denise R. Biochemistry. Seventh edition. Philadelphia: Wolters Kluwer, 2017, viii, 567. ISBN 9781496363541. info
  • Interactive Syllabus of the course in IS MU.
  • Recommended literature from medical physiology in the course aZLFY0422p.
    recommended literature
  • LIEBERMAN, Michael; Allan D. MARKS and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013, ix, 1014. ISBN 9781451100037. info
  • VASUDEVAN, D. M.; S. SREEKUMARI and Kannan VAIDYANATHAN. Textbook of biochemistry for dental students. 3rd edition. New Delhi: Jaypee, 2017, xiii, 289. ISBN 9789352701148. info
  • RODWELL, Victor W.; David A. BENDER and Kathleen M. BOTHAM. Harper's illustrated biochemistry. 30th ed. New York: Mc Graw- Hill, 2015, xii, 817. ISBN 9781259252860. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Color atlas of biochemistry. 3rd ed., rev. and updated. Stuttgart: Thieme, 2013, ix, 495. ISBN 9783131003737. info
Teaching methods
Lectures
Assessment methods
Oral exam.
The student will randomly draw questions from Biochemistry I and Biochemistry II.
Language of instruction
English
Further comments (probably available only in Czech)
Information on completion of the course: Admission to the exam is conditioned by obtaining a credit of the course aZLBC0422s.
The course is taught annually.
The course is taught every week.
Listed among pre-requisites of other courses
Teacher's information
Information about the exam and topics included in the exam is available in the IS MU Study Materials - Organizational Instructions.
The course is also listed under the following terms spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.
  • Enrolment Statistics (spring 2026, recent)
  • Permalink: https://is.muni.cz/course/med/spring2026/aZLBC0422p