VLPF0622c Patholphysiology II - practicals

Faculty of Medicine
spring 2023
Extent and Intensity
0/3/0. 2 credit(s). Type of Completion: z (credit).
Teacher(s)
MUDr. Vendula Bartáková, Ph.D. (seminar tutor)
MUDr. Kamil Ďuriš, Ph.D. (seminar tutor)
doc. MUDr. Jaromír Gumulec, Ph.D. (seminar tutor)
Ing. Hana Holcová Polanská, Ph.D. (seminar tutor)
Mgr. Katarína Chalásová, Ph.D. (seminar tutor)
MUDr. Michal Jurajda, Ph.D. (seminar tutor)
prof. MUDr. Kateřina Kaňková, Ph.D. (seminar tutor)
Mgr. Andrea Knight, Ph.D. (seminar tutor)
MUDr. Jan Máchal, Ph.D. (seminar tutor)
prof. RNDr. Michal Masařík, Ph.D. (seminar tutor)
MUDr. Stanislav Matoušek, Ph.D. (seminar tutor)
MUDr. Petr Müller, Ph.D. (seminar tutor)
Mgr. Lukáš Pácal, Ph.D. (seminar tutor)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (seminar tutor)
Mgr. Jana Šístková, Ph.D. (seminar tutor)
MUDr. Michal Šitina, Ph.D., M.Sc. (seminar tutor)
Mgr. Lucie Válková, Ph.D. (seminar tutor)
prof. MUDr. Anna Vašků, CSc. (seminar tutor)
Bc. Lenka Hladíková (assistant)
Věra Ježková (assistant)
Mgr. Šárka Lakomá (assistant)
Guaranteed by
prof. MUDr. Kateřina Kaňková, Ph.D.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Kateřina Kaňková, Ph.D.
Supplier department: Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Timetable of Seminar Groups
VLPF0622c/01: Mon 13. 2. to Thu 4. 5. Thu 10:00–12:30 B11/228, Thu 10:00–12:30 A18/108, Thu 10:00–12:30 A18/208; and Thu 18. 5. 10:00–12:30 A18/208, 10:00–12:30 A18/108, 10:00–12:30 B11/228, Thu 25. 5. 10:00–12:30 B11/228, 10:00–12:30 A18/208, 10:00–12:30 A18/108
VLPF0622c/02: Mon 13. 2. to Thu 4. 5. Thu 10:00–12:30 A18/108, Thu 10:00–12:30 B11/228, Thu 10:00–12:30 A18/208; and Thu 18. 5. 10:00–12:30 A18/108, 10:00–12:30 A18/208, 10:00–12:30 B11/228, Thu 25. 5. 10:00–12:30 A18/208, 10:00–12:30 A18/108, 10:00–12:30 B11/228
VLPF0622c/03: Tue 10:00–12:30 A18/208, Tue 10:00–12:30 B11/228, Tue 10:00–12:30 A18/108
VLPF0622c/04: Tue 10:00–12:30 A18/108, Tue 10:00–12:30 A18/208, Tue 10:00–12:30 B11/228
VLPF0622c/05: Mon 7:00–9:30 B11/228, Mon 7:00–9:30 A18/208, Mon 7:00–9:30 A18/108
VLPF0622c/06: Mon 7:00–9:30 B11/228, Mon 7:00–9:30 A18/108, Mon 7:00–9:30 A18/208
VLPF0622c/07: Mon 13. 2. to Thu 4. 5. Thu 7:00–9:30 A18/108, Thu 7:00–9:30 B11/228, Thu 7:00–9:30 A18/208; and Thu 18. 5. 7:00–9:30 B11/228, 7:00–9:30 A18/208, 7:00–9:30 A18/108, Thu 25. 5. 7:00–9:30 B11/228, 7:00–9:30 A18/108, 7:00–9:30 A18/208
VLPF0622c/08: Mon 13. 2. to Thu 4. 5. Thu 7:00–9:30 A18/208, Thu 7:00–9:30 A18/108, Thu 7:00–9:30 B11/228; and Thu 18. 5. 7:00–9:30 A18/108, 7:00–9:30 B11/228, 7:00–9:30 A18/208, Thu 25. 5. 7:00–9:30 A18/208, 7:00–9:30 A18/108, 7:00–9:30 B11/228
VLPF0622c/09: Fri 7:00–9:30 B11/228, Fri 7:00–9:30 A18/108, Fri 7:00–9:30 A18/208
VLPF0622c/10: Fri 7:00–9:30 A18/108, Fri 7:00–9:30 B11/228, Fri 7:00–9:30 A18/208
VLPF0622c/11: Mon 10:00–12:30 A18/208, Mon 10:00–12:30 A18/108, Mon 10:00–12:30 B11/228, J. Máchal
VLPF0622c/12: Mon 10:00–12:30 A18/208, Mon 10:00–12:30 B11/228, Mon 10:00–12:30 A18/108, J. Máchal
VLPF0622c/13: Tue 7:00–9:30 A18/208, Tue 7:00–9:30 A18/108, Tue 7:00–9:30 B11/228, J. Máchal
VLPF0622c/14: Tue 7:00–9:30 A18/208, Tue 7:00–9:30 B11/228, Tue 7:00–9:30 A18/108, J. Máchal
VLPF0622c/15: Fri 13:00–15:30 A18/108, Fri 13:00–15:30 A18/208, Fri 13:00–15:30 B11/228
VLPF0622c/16: Fri 13:00–15:30 A18/108, Fri 13:00–15:30 A18/208, Fri 13:00–15:30 B11/228
VLPF0622c/17: Tue 13:00–15:30 B11/228, Tue 13:00–15:30 A18/108, Tue 13:00–15:30 A18/208
VLPF0622c/18: Tue 13:00–15:30 A18/208, Tue 13:00–15:30 B11/228, Tue 13:00–15:30 A18/108
VLPF0622c/19: Wed 10:00–12:30 B11/228, Wed 10:00–12:30 A18/208, Wed 10:00–12:30 A18/108
VLPF0622c/20: Wed 10:00–12:30 A18/208, Wed 10:00–12:30 A18/108, Wed 10:00–12:30 B11/228
Prerequisites
VLPF0521c Pathophysiology I - practicals
Physiology, biochemistry
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The objective of the practical exercises and seminars from pathological physiology is to provide students basic idea about pathological states and experimental work. Students will also acquire practical skills necessary for their subsequent(future) study and work.
Learning outcomes
Student will explain the pharmacological options affecting the secretion of gastric juice in the context of experimentally induced gastric ulcer in experimental animal model (inhibition of proton pump, H2 receptor blockade);
Student will explain the pharmacological options affecting the secretion of gastric juice in the context of experimentally induced gastric ulcer in experimental animal model (inhibition of proton pump, H2 receptor blockade);
Student demonstrates the principle of load test (oGTT) in an animal model of experimentally induced diabetes (alloxan);
Student shall identify clinically relevant parameters describe nutritional status (calorimetry, BMI, WHR index, the weight, the skin-fold thickness, bioimpedance, DEXA) ;
Student demonstrates the examination of the quality of the skin barrier, through the examination of resistance and conductivity of the skin or a chemical (Burckhardt´s) examination with regard to the composition of the skin barrier;
Student demonstrates onset of obstruction icterus induced by ligation of ductus choledochus. He understands etiopathogenesis of other types of icterus (hemolytic, hepatic) and diagnostics of them using heme metabolites in urine, blood and stool using mitochondrial/cytoplasmatic membranes liver enzymes;
Student describes etiopathogenesis of venous thrombosis using data from experimental animal model;
Student will explain the importance and principles of DNA d iagnostics to detect I/D polymorphism using PCR methodology ACE
Syllabus
  • Overview of molecular biology exp. methods used in pathophysiology. Demonstration of selected lab. methods.
  • Acid-base balance (seminar)
  • Selected aspects of glucose metabolism
  • Introduction, health & safety in the lab. Principles and ethics of experimental use of laboratory animals. Training of techniques for experimental practice
  • Introduction to pathophysiology of kidneys - function, GF, secondary hypertension.
  • Exp. induced acute renal insufficiency in lab. animal – measurement of GFR based on renal inulin excretion kinetics
  • Pathophysiology of GIT - gastroduodenal diseases.
  • Haematology, blood transfusion (tutorial)
  • Obstructive jaundice I - preparation
  • Exp. induced jaundice in lab. animal
  • Statistical evaluation of experiments (advanced methods), practical analysis of exp. data (using stat. software)
  • Exp. induced vein thrombosis
  • Neuropathophysiology I - cerebrovascular disorders, intracranial hypertension (bleeding, liquor, …) (tutorial)
  • Pathophysiology of shock and urgent states (MODS, SIRS) (tutorial) Disorders of homeostasis - imbalance of volume, osmolality, tonicity, ABR
Literature
Teaching methods
practical exercize in lab, seminars Practical training (about 20 % of the total volume of teaching) is complemented by a comprehensive range of simulation teaching methods on virtual patients.
Assessment methods
P> Practicals are compulsory (the only permited reason for not attending is a student's sick leave). Students can be given written tests or individual home work by tutor's throughout the term. Student's participation in the practicals throughout the term is certified by a credit given upon the following conditions: (i) complete attendance, (ii) complete protocols from the exp. practicals, (iii) indicidual criteria announced by the principal tutor.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 45.
Listed among pre-requisites of other courses
Teacher's information
http://www.med.muni.cz/patfyz/patfyzc.html
The course is also listed under the following terms Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2024, spring 2025.
  • Enrolment Statistics (spring 2023, recent)
  • Permalink: https://is.muni.cz/course/med/spring2023/VLPF0622c