VLIM051p Immunology - lecture

Faculty of Medicine
autumn 2024
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
prof. MUDr. Tomáš Freiberger, Ph.D. (lecturer)
MUDr. Roman Hakl, Ph.D. (lecturer)
doc. MUDr. Zita Chovancová, Ph.D. (lecturer)
prof. MUDr. Jiří Litzman, CSc. (lecturer)
Guaranteed by
prof. MUDr. Jiří Litzman, CSc.
Department of Clinical Immunology and Allergology – Institutions shared with St. Anne's Faculty Hospital – Faculty of Medicine
Contact Person: prof. MUDr. Jiří Litzman, CSc.
Supplier department: Department of Clinical Immunology and Allergology – Institutions shared with St. Anne's Faculty Hospital – Faculty of Medicine
Prerequisites (in Czech)
( VLBC0422p Biochemistry II - lecture || VSBC0221p Biochemistry I -lect. ) && ( VSFY0422p Physiology II - lecture || VLFY0422p Physiology II - lecture )
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course covers basic aspects of the structure and function of the immune system in humans. Topics include mechanisms of non- specific immunity with main emphasis on the inflammatory process, such as humoral and cellular branches of the specific immune response. It includes mainly mechanisms of activation of the immune response and its regulation. Special emphasis is given to immune response to microbes and immunoprophylaxis to infectious and non-infectious diseases. After finishing the course the students will understand and be able to explain the mechanisms of the immune response in physiology, such as immune system disturbances leading to immunopathological diseases.
Learning outcomes
- Student will understand basic mechanisms of functioning of the immune system, functional characteristics of specific and non-specific immune response, and the interrelationship of these reactions;
- The student will understand the importance of the immune system in defense against microbes and tumor growth as well as the principles of active and passive artificial immunization;
- The student will become acquainted with the regional specificity of the individual compartments of the immune system;
- Student will be acquaint with the mechanisms of immune tolerance and the mechanisms of its breakdown leading to autoimmune diseases;
- The student will be familiar with the principles of immunological hypersensitivity and the consequences leading to the development of hypersensitivity reactions;
- Students will be acquainted with basic principles of pharmacological influence of immune reactivity;
- Students will be acquainted with the most important primary and secondary immunodeficiecy states;
  • Immunology in medicine. Medical subject allergology and clinical immunology. Physiology and pathology of the immune system.
  • Immunological concept of “own”, “foreign”, “dangerous”.
  • Anatomy and cellular elements of the immune system.
  • Innate or natural immunity: phagocytosis, NK cells, cytotoxicity, interferon system, complement system, acute phase reaction, inflammation.
  • B lymphocytes and immunoglobulins.Genetic basis of immunoglobulin heterogeneity.Biological properties of antibodies.
  • T-lymphocytes, their development and effector functions. Polarisation of T-lymphocytes (T1, T2, Th17). Cytotoxicity. Cytokines. Major histocompatibility complex: structure, function.
  • Activation of T and B cells by antigen.Interactions between antigen-presenting cells and T- and B-lymphocytes.
  • Regulation of the immune reaction.
  • Compartmentalization of the immune response. Mucosal immunity.
  • Immunity against infectious agents. Microbial antigens.
  • Active and passive immunisation.
  • Age factor and immune system in humans
    recommended literature
  • HOŘEJŠÍ, Václav, Jiřina BARTŮŇKOVÁ, Tomáš BRDIČKA and Radek ŠPÍŠEK. Základy imunologie. 6., aktualizované vydání. V Praze: Stanislav Juhaňák - Triton, 2017, 297 stran. ISBN 9788075532503. info
  • ABBAS, Abul K., Andrew H. LICHTMAN and Shiv PILLAI. Basic immunology : functions and disorders of the immune system. Fifth edition. St. Louis: Elsevier, 2016, x, 335. ISBN 9780323390828. info
Teaching methods
The subject is given in a form of lectures
Assessment methods
Oral exam.
Language of instruction
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.
Information on the extent and intensity of the course: 15.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2023.
  • Enrolment Statistics (recent)
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