VLPF0622p Pathophysiology II - lecture

Faculty of Medicine
spring 2024
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Taught in person.
prof. MUDr. Kateřina Kaňková, Ph.D. (lecturer)
prof. MUDr. Anna Vašků, CSc. (lecturer)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (lecturer)
prof. MUDr. Julie Dobrovolná, Ph.D. (lecturer)
doc. RNDr. Sabina Ševčíková, Ph.D. (lecturer)
MUDr. Michal Jurajda, Ph.D. (lecturer)
prof. RNDr. Michal Masařík, Ph.D. (lecturer)
MUDr. Jan Máchal, Ph.D. (seminar tutor)
Bc. Lenka Hladíková (assistant)
Mgr. Katarína Chalásová, Ph.D. (assistant)
Mgr. Lukáš Pácal, Ph.D. (assistant)
doc. MUDr. Jaromír Gumulec, Ph.D. (alternate examiner)
Guaranteed by
prof. MUDr. Kateřina Kaňková, Ph.D.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Kateřina Kaňková, Ph.D.
Supplier department: Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Wed 14:00–15:40 B22/116 aula
Prerequisites (in Czech)
VLPF0521c Pathophysiology I - practicals
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the subject is to train general medicine students in dynamic thinking about etiology and pathogenesis of diseases focused on special pathophysiology as well as molecular pathophysiology themes:
Pathophysiology of cardiovascular system.
Pathophysiology of digestive system, nutrition deficits.
Pathophysiology of endocrine system, metabolic diseases.
Pathophysiology of hemopoietic system, neoplasias.
Rheumatic diseases. Immunologically conditioned diseases.
Pathophysiology of respiratory tract.
Pathofphysiology of kidneys, disturbances in metabolism of water and ions.
Pathophysiology of nervous system.
Pathophysiology of muscles and sensory organs.
Learning outcomes
Student discusses the etiopathogenesis of atherosclerosis at the molecular, cellular and tissue level
Student will describe the etiopathogenesis of systolic and diastolic dysfunction of myocardium and pressure and volume overload of the heart
Student distinguishes between the causes of arrhythmias
Student categorizes the clinical forms of ischemic heart disease and clinically important consequences of heart failure syndrome
Student will explain the general and special pathophysiology of shock conditions and basic types of shock
Student will sum up the most common causes of disorders of the respiratory apparatus
Student characterizes the pathophysiology of chronic bronchitis and pulmonary emphysema
Student will sum up the pathogenesis of respiratory insufficiency
Student controls the issue of regulation of renal perfusion
Student can explain the issue glomerulopathy
Student categorizes causes of acute and chronic renal failure
Student will explain the difference between acute and chronic effects of hormones
Student categorizes acute and chronic renal failure
Student will explain the difference between acute and chronic effects of hormones
Student discusses the pathophysiology of clinically significant endocrine disruption of the function
Student will describe the pathophysiology of clinically significant gastrointestinal disorders, from a clinical point of view
Student will describe the anemic syndrome including the effects of anemic hypoxia
Student discusses different classification of anemias
Student discusses the pathophysiological aspects of transfusion of blood and blood derivatives,
Student will describe the main categories of diseases of white blood cells
Student distinguishes principled differences between physiological and pathological blood clotting
Student discusses the most important hypocoagulation and hypercoagulation disorders
Student will sum up the etiopathogenesis of common diseases of the joints,
Student demonstrates a knowledge of the etiopathogenesis of diseases of the muscle and neuromuscular plate
Student rattles off examples of failures of a sensory sensation
Student demonstrates examples of common neurodegenerative diseases of CNS
Student discusses the pathophysiology of epilepsy,
Student will use knowledge of the composition of cerebrospinal fluid
Student argues the importance of stability of intracranial pressure and its components for the creation of intracranial hypertension
Student will sum up the function of autonomous (vegetative) system
Student will sum up the function of movement system and consequences of its failure
Student describes the systems important for the existence of consciousness and waking
  • DNA diagnostics in complex diseases. Pharmacogenetics and gene therapy
  • General pathophysiology of endocrine system
  • Special pathophysiology of endocrine system
  • Pathophysiology of fetoplacental unit
  • Pathophysiology of food intake disorders
  • Pathophysiology of gastrointestinal disorders
  • Pathophysiology of bones and muscles
  • Pathophysiology of chosen allergic and autoimmune disorders
  • Pathophysiology of hematopoiesis and blood clotting
  • Pathophysiological aspects of protein metabolism
  • Pathophysiological aspects of lipid metabolism
  • Pathophysiological aspects of sugars metabolism
  • Pathophysiology of motoric system
  • Neurodegenerative disorders
  • Pathophysiology of urgent events in oncology diseases
    required literature
  • NEČAS, Emanuel and A KOLEKTIV. Obecná patologická fyziologie. 1. vyd. Praha: Karolinum, 2000, 377 pp. info
  • NEČAS, Emanuel. Patologická fyziologie orgánových systémů. 1. vyd. Praha: Karolinum, 2003, s. 381-760. ISBN 9788024606743. info
  • DAMJANOV, Ivan. Pathophysiology. Illustrated by Matthew Chansky. 1st ed. Philadelphia: Saunders/Elsevier, 2009, vii, 464. ISBN 9781416002291. info
Teaching methods
Assessment methods
Oral exam. The final exam is oral; student will answer 4 questions selected by lot from general, special pathophysiology, practicals and lectures. Individual evaluation from practicals (described by assistant) is taken into account.
Language of instruction
Further comments (probably available only in Czech)
Study Materials
The course is taught each semester.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2025.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/med/spring2024/VLPF0622p