VLPF0622p Pathophysiology II - lecture

Faculty of Medicine
spring 2021
Extent and Intensity
2/0/0. 5 credit(s). Type of Completion: zk (examination).
Taught online.
prof. MUDr. Kateřina Kaňková, Ph.D. (lecturer)
prof. MUDr. Anna Vašků, CSc. (lecturer)
doc. RNDr. Monika Pávková Goldbergová, Ph.D. (lecturer)
prof. MUDr. Julie Dobrovolná, Ph.D. (lecturer)
doc. RNDr. Sabina Ševčíková, Ph.D. (lecturer)
Mgr. Katarína Chalásová, Ph.D. (assistant)
Věra Ježková (assistant)
Guaranteed by
prof. MUDr. Kateřina Kaňková, Ph.D.
Department of Pathophysiology - Theoretical Departments - Faculty of Medicine
Contact Person: prof. MUDr. Kateřina Kaňková, Ph.D.
Supplier department: Department of Pathophysiology - Theoretical Departments - Faculty of Medicine
Tue 14:00–15:40 B22/116 aula
Prerequisites (in Czech)
VLPF0521c Pathophysiology I - practicals
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the subject is to train medical students in preclinical thinking with a focus on etiology and pathogenesis of diseases and its dynamics in the context of organ system pathophysiology as well as general pathophysiology incl.:
Pathophysiology of cardiovascular system.
Pathophysiology of digestive system, nutrition deficits.
Pathophysiology of endocrine system, metabolic diseases.
Pathophysiology of hemopoietic system, neoplasias.
Rheumatic diseases. Immunologically conditioned diseases.
Pathophysiology of respiratory tract.
Pathofphysiology of kidneys, disturbances in metabolism of water and ions.
Pathophysiology of nervous system.
Pathophysiology of muscles and sensory organs.
Learning outcomes
Student discusses the etiopathogenesis of atherosclerosis at the molecular, cellular and tissue level
Student will describe the etiopathogenesis of systolic and diastolic dysfunction of myocardium and pressure and volume overload of the heart
Student distinguishes between the causes of arrhythmias
Student categorizes the clinical forms of ischemic heart disease and clinically important consequences of heart failure syndrome
Student will explain the general and special pathophysiology of shock conditions and basic types of shock
Student will sum up the most common causes of disorders of the respiratory apparatus
Student characterizes the pathophysiology of chronic bronchitis and pulmonary emphysema
Student will sum up the pathogenesis of respiratory insufficiency
Student controls the issue of regulation of renal perfusion
Student can explain the issue glomerulopathy
Student categorizes causes of acute and chronic renal failure
Student will explain the difference between acute and chronic effects of hormones
Student categorizes acute and chronic renal failure
Student will explain the difference between acute and chronic effects of hormones
Student discusses the pathophysiology of clinically significant endocrine disruption of the function
Student will describe the pathophysiology of clinically significant gastrointestinal disorders, from a clinical point of view
Student will describe the anemic syndrome including the effects of anemic hypoxia
Student discusses different classification of anemias
Student discusses the pathophysiological aspects of transfusion of blood and blood derivatives,
Student will describe the main categories of diseases of white blood cells
Student distinguishes principled differences between physiological and pathological blood clotting
Student discusses the most important hypocoagulation and hypercoagulation disorders
Student will sum up the etiopathogenesis of common diseases of the joints,
Student demonstrates a knowledge of the etiopathogenesis of diseases of the muscle and neuromuscular plate
Student rattles off examples of failures of a sensory sensation
Student demonstrates examples of common neurodegenerative diseases of CNS
Student discusses the pathophysiology of epilepsy,
Student will use knowledge of the composition of cerebrospinal fluid
Student argues the importance of stability of intracranial pressure and its components for the creation of intracranial hypertension
Student will sum up the function of autonomous (vegetative) system
Student will sum up the function of movement system and consequences of its failure
Student describes the systems important for the existence of consciousness and waking
  • 1. Pathophysiology of GIT II – bowel diseases (incl. IBD) and etiopathogenesis of common malabsorption syndromes
  • 2. Pathophysiology of GIT III – etiopathogenesis of liver, pancreas and biliary tract disorders
  • 3. Pathophysiology of endocrine system I – homeostasis, principles of regulation and its disorders, chronobiology, central endocrine glands (hypothalamus, pituitary)
  • 4. Pathophysiology of endocrine system II – reproductive endocrinology disorders (ovaries, testes), abnormalities of fertility (PCOS), fetoplacental unit and pathophysiology of pregnancy (preeclampsia etc.)
  • 5. Pathophysiology of endocrine system III – adrenal cortex and medulla, thyroid gland
  • 6. Pathophysiology of endocrine system IV – parathyroid gland, metabolism and deficiency of D vitamins, calcium and phosphate metabolism disorders, pathological bone remodelling
  • 7. Host: Patofyziologie vnitřní sekrece V - Je inzulínová rezistence výhradně patologický proces?
  • 8. Pathophysiology of hematopoietic system I – haematological malignancies and precancerous states (myelodysplastic syndrome, leukaemias, lymphomas and multiple myeloma)
  • 9. Pathophysiology of hematopoietic system II – disorders of primary and secondary haemostasis (common hypo- and hypercoagulation states), thrombosis and embolization in typical locations
  • 10. Guest: Pathophysiology of hematopoietic system II – iron metabolism regulation and its disorders, etiopathogenesis of selected forms of anaemias (sideropenic, chron. disease), iron overload
  • 11.Pathophysiology of musculoskeletal system (bones, joints and muscles) incl. rheumatology (arthritis in systemic autoimmune diseases), muscular dystrophies, sarcopenia etc.
  • 12. Pathophysiology of nervous system I - motoric system (motoneurons, neuro-muscular junction, extrapyramidal system, cerebellum)
  • 13. Pathophysiology of nervous system II – etiopathogenic mechanisms od selected CNS disease (demyelinisation, neurodegeneration, neuroinflammation)
  • 14. Integrated pathophysiology of fluid, electrolyte and pH homeostasis
  • 15. Pathophysiology of age-related processes, aging, longevity, death
    required literature
  • NEČAS, Emanuel. Obecná patologická fyziologie. 3. vyd. Praha: Karolinum, 2009. 377 s. ISBN 9788024616889. info
  • NEČAS, Emanuel. Patologická fyziologie orgánových systémů. 2. vyd. Praha: Karolinum, 2009. 379 s. ISBN 9788024617107. info
    recommended literature
  • DAMJANOV, Ivan. Pathophysiology. Illustrated by Matt Chansky. 1st ed. Philadelphia: Saunders/Elsevier, 2009. vii, 464. ISBN 9781416002291. info
Teaching methods
Assessment methods
Pathophysiology course is finalised by an oral exam. Student will select questions from 4 different topics and he/she is given time to prepare answers (up to 120 min). Following topics will be represented by 1 question in oral exam:
Set P: practicals
Set G: general pathophysiology
Set S1: circulatory, respiratory, excretory and nervous system pathophysiology
Set S2: gastrointestinal, endocrine, hematopoietic and musculoskeletal system pathophysiology
Study materials include practical tutorials, recommended literature and handouts provided for lectures. Results/cumulative number of points obtained in tests can be taken into account by examiner for final grade.
Language of instruction
Further comments (probably available only in Czech)
Study Materials
The course is taught each semester.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses

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Teacher's information
Lectures are scheduled at the Auditorium UKB (A22) Wednesdays 15:00-16:40
The course is also listed under the following terms Spring 2018, spring 2019, spring 2020.
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