VSPF0622p Pathological Physiology II - lectures

Faculty of Medicine
Spring 2018
Extent and Intensity
2/0/0. 5 credit(s). Type of Completion: zk (examination).
prof. MUDr. Anna Vašků, CSc. (lecturer)
prof. MUDr. Kateřina Kaňková, Ph.D. (lecturer)
prof. MUDr. Julie Dobrovolná, Ph.D. (lecturer)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (lecturer)
Věra Ježková (assistant)
Guaranteed by
prof. MUDr. Anna Vašků, CSc.
Department of Pathophysiology - Theoretical Departments - Faculty of Medicine
Contact Person: prof. MUDr. Anna Vašků, CSc.
Supplier department: Department of Pathophysiology - Theoretical Departments - Faculty of Medicine
Prerequisites (in Czech)
VSPF0521c Pathophysiol. I - practice.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the subject is to train general medicine students in dynamic thinking about etiology and pathogenesis of diseases focused on special pathophysiology as well as molecular pathophysiology themes:
Pathophysiology of digestive system, nutrition deficits.
Pathophysiology of endocrine system, metabolic diseases.
Pathophysiology of hemopoietic system, neoplasias.
Rheumatic diseases. Immunologically conditioned diseases.
Pathophysiology of nervous system.
Pathophysiology of muscles and sensory organs.
Learning outcomes
The student will describe the basic principles of methods used to analyze the human genome
The student will sum up the basic types of DNA repair
The student characterizes the basic features of monogenic disease
The student discusses the basic principles of and indications for gene therapy
The student knows the importance of the concept of pharmacogenetics
The student discusses the issues involved in protein metabolism
The student will sum up the metabolism of lipids
The student interprets the immunological recognition of their own knowledge of the principles and foreign structures
The student interprets the immunological hypersensitivity mechanisms
The student will explain the difference between acute and chronic effects of hormones
The student discusses the pathophysiology of disorders of the hypothalamus
The student discusses the pathophysiology of disorders of adrenal cortex
The student discusses the pathophysiology of disorders of thyroid and parathyroid glands
The student will explain the pathophysiological aspects of sex hormones
The student will describe the failure to regulate the production of HCl
The student discusses diseases of the esophagus
Student categorizes chronic gastritis, summarizing the role of Helicobacter pylori
The student controls the issue of inflammatory intestinal inflammations (
The student shall identify the oral cavity and also manifestations of systemic diseases
The student discusses the relative to the population prevalence of specific issues   colorectal cancer
The student identifies aetiological factors of liver damage
The student applies acquired knowledge to clarify the consequences of portal hypertension
The student will sum up the abnormalities that characterize the liver failure
The student will describe the common bile duct disorders
The student discusses haemoglobinopathies
The student will describe the clinical perspective of   anemic syndrome
The student discusses the different classifications of anemia
The student discusses the implications of the pathological conditions of the spleen
The student discusses the pathophysiological aspects of transfusion of blood and blood derivatives
The student applies knowledge of the function of the HLA system to an explanation of the issue of transplantation immunity
The student will describe the basic categories of disease of the white blood
Students rattle off examples of failures of a sensory sensation
The student demonstrates examples of neurodegenerative diseases
The student will use the knowledge about the composition of cerebrospinal fluid to     explanation diagnostic contribution of its analysis
Student argues the importance of stability of intracranial pressure and its components for the emergence of intracranial hypertension
The student applies the somatotopic aspect of the pathophysiology of the disease of the spinal cord
The student will sum up the function of autonomous system
The student will sum up the function of somatic efferent system of movement
The student will sum up the function of somatic efferent system of the pyramids and the causes and consequences of their failures
The student defines cognitive function
The student discusses the etiopathogenesis of cerebral events
The student discusses the principle of the perception of pain
The student can list the common causes of disorders of the nervous system
Students rattle off the systems important for the existence of consciousness and waking, indicating the classification of disorders of consciousness on the qualitative and quantitative.
  • Pathophysiology of gastrointestinal system
  • Pathophysiology of fetoplacental unit
  • Pathophysiological aspects of chosen allergic and autoimmune diseases Pathophysiological aspects of oncologic emergencies
  • General pathophysiology of endocrine system
  • Special pathophysiology of endocrine system
  • Pathophysiology of lipid metabolism defects
  • Pathophysiology of nervous system: motoric system
  • Pathophysiology of nervous system: degenerative disorders
  • DNA diagnostics in complex diseases. Basic principles of pharmacogenomics and personalized medicine
    required literature
  • NEČAS, Emanuel and A KOLEKTIV. Obecná patologická fyziologie. 1. vyd. Praha: Karolinum, 2000. 377 pp. info
  • NEČAS, Emanuel. Patologická fyziologie orgánových systémů. 1. vyd. Praha: Karolinum, 2003. s. 381-760. ISBN 9788024606743. info
    recommended literature
  • DAMJANOV, Ivan. Pathophysiology. Illustrated by Matthew Chansky. 1st ed. Philadelphia: Saunders/Elsevier, 2009. vii, 464. ISBN 9781416002291. info
Teaching methods
Assessment methods
Oral exam. The final exam is oral; student will answer 4 questions selected by lot from general, special pathophysiology, practicals and lectures. Individual evaluation from practicals (described by assistant) is taken into account.
Language of instruction
Further comments (probably available only in Czech)
Study Materials
The course is taught each semester.
The course is taught: every week.
Listed among pre-requisites of other courses
Teacher's information
Lectures are given at the Department od Pathophysiology, UCB, A18, S112 on Thuesdays, 16:30-18:00
The course is also listed under the following terms Spring 2000, Spring 2001, Spring 2002, Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017.
  • Enrolment Statistics (recent)
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