VLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2019
Extent and Intensity
2/0/0. 7 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Ing. Martina Čarnecká, Ph.D. (assistant)
Mgr. Martina Drabinová (assistant)
MUDr. Lenka Fědorová (assistant)
Mgr. Jana Gregorová, Ph.D. (assistant)
MUDr. Miroslava Hlaváčová, Ph.D. (assistant)
PharmDr. Katarína Kostolanská (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
Lenka Nerudová (assistant)
Mgr. Lucie Novotná (assistant)
Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Anna Pleskačová (assistant)
MUDr. RNDr. Michal Řiháček (assistant)
Mgr. Roman Sándor (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Supervisor
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Supplier department: Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Timetable
Tue 7:00–8:40 A22/116 aula
Prerequisites (in Czech)
( VLBI0222p Biology II-lect. || VSBI0222p Biology II-lect. ) && VLBF011p Biophysics-lect. && VLBC0321s Biochemistry I sem && VLBC0321c Biochemistry I && VLFY0321c Physiology I - practice && VLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
Fields of study the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with integration of biochemical processes in human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. It is also an introduction to clinical biochemistry.
Learning outcomes
The student is able to explain the interrelationship between the metabolism of nutrients under different states of the organism. Describes the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases. Understands and discusses principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations It discusses the composition of body fluids and their disorders in connection with the principles of homeostasis. It explains the principles of metabolism regulation at all levels.
Syllabus
  • Digestion and absorption of lipids. Blood plasma lipids and the major groups of lipoproteins. Metabolic fate of chylomicrons and VLDL, the metabolism of HDL
  • The integration of intermediary metabolism at the tissue and organ level (after the meal, during starvation, stress, obesity, diabetes).
  • The metabolic functions of the liver. Metabolism of main nutrients. Catabolism of haemoglobin, bilirubin metabolism. Metabolism of iron and copper.
  • Biotransformation of xenobiotics. Two phases of biotransformation, typical reactions, cytochrome P450. Metabolism of ethanol. Water and Na+, K+ ions balance, osmolality and volume of ECF, regulation, disorders.
  • Transport of O2 and CO2. Metabolic pathways producing/consuming H+ ions.Buffer bases of blood, blood plasma, ICF, the parameters of acid-base status.
  • Normal renal functions. Glomerular filtration. Tubular resorption and secretion.
  • Steroid and thyroid hormones – biosynthesis, secretion, and effects.
  • Control of metabolism. Mechanism of hormone and neurotransmitter action. Types of cell membrane receptors, intracellular effects of ligand binding; intracellular receptors.
  • Metabolism of nervous tissue. Neuro-secretion. The biosynthesis and inactivation of neurotransmitters, neurotransmission across synapses. Cholinergic, adrenergic, and (inhibitory) gabaergic receptors.
  • Metabolism of calcium, magnesium, phosphates, fluorine, and iodine. Hormones involved in their metabolism.
  • The extracellular matrix. Synthesis and post-translational modifications of collagen, intermolecular crosslinks in collagen and elastin, proteoglycans. Calcification of bone, regulation. Biochemical markers of bone resorption and formation.
  • The major proteins of blood plasma. Endothelial cells. The blood-coagulation cascade, inhibition of clotting. Fibrinogen, fibrin, fibrinolysis.
  • Biochemistry of blood cells. Molecular principles of immunochemistry.
Literature
    required literature
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012. xii, 730. ISBN 9788072629077. info
Teaching methods
Teaching form are lectures. Supplementary subjects are seminars and practicals (VSBC041c and VSBC041s).
Assessment methods
Student must have course-unit credit of seminar and practicals in the day of exam.
The examination has writen and oral part. The test consists of 25 questions and is solved on computers in the computer room of Department of Biochemistry (personal university ID /UCO/ and pass-word for IS MUNI is necessary for entrance to the test): As a rule, 10 questions are from practical exercises. Remaining 15 questions cover essential knowledge ranging over all studied topics. Only those students who gain 14 correct answers at a minimum will be permitted to sit for the oral examination. The oral part of examination Students select three questions and have about 30 minutes for the written preparation. They should summarize their answers as concisely and accurately as possible. It is recommended to follow these items: - to write a brief synopsis emphasizing the main ideas. - to draw metabolic pathways in structural formulas with a short comment. - where appropriate, to draw a picture. A good and concise preparation reflects the students’ knowledge and understanding the biochemistry and will be considered in the final classification.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses

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The course is also listed under the following terms Spring 2017, Spring 2018.
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