VLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2024
Extent and Intensity
2/0/0. 4 credit(s). Type of Completion: zk (examination).
Taught in person.
doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. David Galuška (assistant)
MUDr. Lenka Gescheidtová, Ph.D. (assistant)
Mgr. Jana Gregorová, Ph.D. (assistant)
doc. PharmDr. Jiří Kos, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
doc. Mgr. Ondřej Peš, Ph.D. (assistant)
MUDr. RNDr. Michal Řiháček, Ph.D. (assistant)
Bc. Ivana Ševčíková (assistant)
Mgr. Pavel Šmak (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (alternate examiner)
Mgr. Jiří Slanina, Ph.D. (alternate examiner)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Supplier department: Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Prerequisites (in Czech)
VLBC0321s Biochemistry I - seminar && VLFY0321c Physiology I - practice && VLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with integration of biochemical processes in human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. It is also an introduction to clinical biochemistry.
Learning outcomes
After completing the course, the student is able to:
- explain the interrelationships between the metabolism of nutrients in different states of the organism.
- describe the metabolic characteristics of the main organs and tissues and the main disorders, and discuss their connection with diseases.
- explain the principles of metabolism regulation at all levels.
- understand the principles of maintaining homeostasis in the organism and acid-base balance, including solving model situations.
- discuss the composition of body fluids and their disorders in connection with the principles of homeostasis.
  • Blood plasma lipids. Metabolism of lipoproteins.
  • Overview of nutrient metabolism in different states.
  • Metabolic functions of liver. Catabolism of heme. Biochemical tests for liver diseases.
  • Metabolism of iron and copper. Biotransformation of xenobiotics. Metabolism of ethanol.
  • Water and Na+, K+ ions balance, osmolality and volume of ECF.
  • Acid-base balance. Transport of O2 and CO2. Buffer bases. Parameters of acid-base status.
  • Biochemical functions of kidneys. Glomerular filtration. Tubular resorption and secretion.
  • General mechanisms of action of signal molecules. Hormone receptors.
  • Steroid and thyroid hormones.
  • Nervous tissue. Cerebrospinal fluid. Neurosecretion. Neurotransmitters and their receptors.
  • Endothelial cells. Blood-coagulation cascade, inhibition of clotting. Fibrinolysis.
  • Metabolism of calcium, magnesium, phosphates, fluorine, and iodine.
  • Extracellular matrix. Bone tissue. Articular cartilage and skin.
  • Biochemistry of blood cells. Major proteins of blood plasma.
    required literature
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012. xii, 730. ISBN 9788072629077. info
  • Studijní podklady a materiály k předmětu dostupné v IS MUNI.
    recommended literature
  • LIEBERMAN, Michael and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 5th edition. Philadelphia: Wolters Kluwer, 2018. xii, 1051. ISBN 9781496387721. info
  • RONNER, Peter. Netter's Essential Biochemistry. Philadelphia: Elsevier, 2018. 482 pp. ISBN 978-1-929007-63-9. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Translated by Vladimír Benda - Martin Vejražka - Jiří Jonák. 1. české vydání. Praha: Grada, 2012. xiv, 498. ISBN 9788024729770. info
  • VASUDEVAN, D. M., S. SREEKUMARI and Kannan VAIDYANATHAN. Úvod do všeobecnej a klinicky aplikovanej biochémie. Edited by Jozef Čársky. Prvé slovenské vydanie. Bratislava: Balneotherma s.r.o., 2015. 669 stran. ISBN 9788097015688. info
  • Doporučovaná literatura z lékařské fyziologie v předmětu VLFY0422p.
Teaching methods
Assessment methods
Oral exam. Student draws two questions from Biochemistry I and two questions from Biochemistry II. The student answers the questions without preparation.
Language of instruction
Further comments (probably available only in Czech)
Information on completion of the course: přistoupení ke zkoušce je podmíněno úspěšným ukončením předmětů VLBC0422s, VLBC0422c a VLBC0422t.
The course is taught annually.
The course is taught: every week.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
The basic concepts and topics covered in the exam are available in the Course-Related Instructions in IS MUNI.
The course is also listed under the following terms Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023.
  • Enrolment Statistics (spring 2024, recent)
  • Permalink: https://is.muni.cz/course/med/spring2024/VLBC0422p