VLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2027
Extent and Intensity
2/0/0. 4 credit(s). Type of Completion: zk (examination).
In-person direct teaching
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
MUDr. Michaela Králíková, Ph.D. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Iva Audy (assistant)
Mgr. Jana Gregorová, Ph.D. (assistant)
doc. PharmDr. Jiří Kos, Ph.D. (assistant)
Ing. Bc. Hana Logerová, Ph.D. (assistant)
doc. Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Michaela Šimurdová (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: RNDr. Hana Paulová, CSc.
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Prerequisites (in Czech)
VLBC0321s Biochemistry I - seminar && VLFY0321c Physiology I - practice && VLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Abstract
The course provides an overview of the biochemical functions of major human organ systems, with emphasis on their metabolic, regulatory, and diagnostically relevant processes. It highlights the links between biochemical mechanisms, physiology, and pathophysiology, including the interpretation of laboratory parameters used in clinical practice. The course builds on fundamental cellular biochemistry and expands it with applied concepts essential for understanding and diagnosing selected diseases.
Learning outcomes
Upon successful completion of the course, the student will be able to:
  • explain the relationships and regulation of nutrient metabolism in various physiological and pathological states;
  • describe the metabolic functions of major organs and analyse their disorders;
  • explain the principles of hormonal, neural, and metabolic regulation at the molecular, cellular, tissue, and systemic levels;
  • apply the principles of homeostasis and acid–base balance in solving model clinical situations;
  • interpret the composition of body fluids and evaluate its alterations in relation to disturbances of homeostasis.
Key topics
  • Metabolism of plasma lipids and lipoproteins.
  • Integrated metabolism of nutrients in various physiological states.
  • Metabolic functions of the liver, heme catabolism, and laboratory markers of liver diseases.
  • Metabolism of iron and copper, biotransformation of xenobiotics, and ethanol metabolism.
  • Homeostasis of water and ions (Na⁺, K⁺), plasma osmolality, and regulation of volemia.
  • Acid–base balance, buffering systems, and transport of O₂ and CO₂ in blood.
  • Biochemistry of the kidneys: glomerular filtration, tubular reabsorption, and secretion.
  • Mechanisms of action of signalling molecules and hormone receptors.
  • Steroid and thyroid hormones.
  • Biochemistry of nervous tissue, cerebrospinal fluid, neurosecretion, and neurotransmitter systems.
  • Biochemistry of the vascular endothelium, haemocoagulation, and anticoagulant mechanisms.
  • Metabolism of minerals: calcium, magnesium, phosphates, fluoride, and iodine.
  • Biochemistry of the extracellular matrix, bone tissue, cartilage, and skin.
  • Biochemistry of blood elements and major plasma proteins.
Study resources and literature
    required literature
  • MURRAY, Robert K.; David A. BENDER; Kathleen M. BOTHAM; Peter J. KENNELLY; Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012, xii, 730. ISBN 9788072629077. info
  • Interaktivní osnova v IS MU.
  • Doporučovaná literatura z lékařské fyziologie v předmětu VLFY0422p.
    recommended literature
  • LIEBERMAN, Michael and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 5th edition. Philadelphia: Wolters Kluwer, 2018, xii, 1051. ISBN 9781496387721. info
  • RONNER, Peter. Netter's Essential Biochemistry. Philadelphia: Elsevier, 2018, 482 pp. ISBN 978-1-929007-63-9. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Translated by Vladimír Benda - Martin Vejražka - Jiří Jonák. 1. české vydání. Praha: Grada, 2012, xiv, 498. ISBN 9788024729770. info
  • VASUDEVAN, D. M.; S. SREEKUMARI and Kannan VAIDYANATHAN. Úvod do všeobecnej a klinicky aplikovanej biochémie. Edited by Jozef Čársky. Prvé slovenské vydanie. Bratislava: Balneotherma s.r.o., 2015, 669 stran. ISBN 9788097015688. info
Approaches, practices, and methods used in teaching
Lectures
Method of verifying learning outcomes and course completion requirements
Oral exam.
The student draws questions from Biochemistry I and Biochemistry II.
Language of instruction
Czech
Further comments (probably available only in Czech)
Information on completion of the course: přistoupení ke zkoušce je podmíněno úspěšným ukončením předmětů VLBC0422s, VLBC0422c a VLBC0422t.
The course is taught annually.
The course is taught every week.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
Information regarding the examination, including the thematic areas covered, is available in the IS MU Study Materials.
The course is also listed under the following terms Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025, spring 2026.
  • Enrolment Statistics (spring 2027, recent)
  • Permalink: https://is.muni.cz/course/med/spring2027/VLBC0422p