VLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2022
Extent and Intensity
2/0/0. 4 credit(s). Type of Completion: zk (examination).
Taught partially online.
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. David Galuška (assistant)
MUDr. Lenka Gescheidtová, Ph.D. (assistant)
Mgr. Jana Gregorová, Ph.D. (assistant)
PharmDr. Jiří Kos, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Ondřej Peš, Ph.D. (assistant)
MUDr. RNDr. Michal Řiháček (assistant)
Bc. Ivana Ševčíková (assistant)
Mgr. Pavel Šmak (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (alternate examiner)
Mgr. Jiří Slanina, Ph.D. (alternate examiner)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Contact Person: prof. RNDr. Eva Táborská, CSc.
Supplier department: Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Timetable
Tue 7:30–9:20 B22/116 aula
Prerequisites (in Czech)
VLBC0321s Biochemistry I - seminar && VLFY0321c Physiology I - practice && VLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with integration of biochemical processes in human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. It is also an introduction to clinical biochemistry.
Learning outcomes
The student is able to explain the interrelationship between the metabolism of nutrients under different states of the organism. Describes the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases. Understands and discusses principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations It discusses the composition of body fluids and their disorders in connection with the principles of homeostasis. It explains the principles of metabolism regulation at all levels.
Syllabus
  • Plasma lipids. Lipoprotein metabolism.
  • Nutrient metabolism in different conditions.
  • Biochemical functions of the liver. Heme catabolism.
  • Iron and copper metabolism. Biotransformation of xenobiotics. Ethanol metabolism.
  • Homeostasis of water, Na+ and K + ions. Regulation of osmolality and volemia.
  • Acid-base balance. Transport of O2 and CO2 in blood. Buffer bases.
  • Biochemical functions of the kidneys. Filtration functions. Tubular resorption and secretion.
  • Steroid and thyroid hormones.
  • Membrane and intracellular receptors. Nervous tissue metabolism. Neurotransmitters, synapses.
  • Metabolism of calcium, magnesium, phosphates, fluorine and iodine.
  • Vascular endothelium. Hemocoagulation, fibrinolysis.
  • Biochemistry of blood elements. The most important blood plasma proteins.
  • Extracellular matrix. Connective tissue metabolism.
Literature
    required literature
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012. xii, 730. ISBN 9788072629077. info
  • Supplementary materials: https://is.muni.cz/auth/el/med/jaro2022/VLBC0422s/um/
    recommended literature
  • LIEBERMAN, Michael and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 5th edition. Philadelphia: Wolters Kluwer, 2018. xii, 1051. ISBN 9781496387721. info
  • BORON, Walter F. and Emile L. BOULPAEP. Medical physiology. Third edition. Philadelphia: Elsevier, 2017. xii, 1297. ISBN 9781455743773. info
  • RONNER, Peter. Netter's Essential Biochemistry. Philadelphia: Elsevier, 2018. 482 pp. ISBN 978-1-929007-63-9. info
  • VASUDEVAN, D. M., S. SREEKUMARI and Kannan VAIDYANATHAN. Úvod do všeobecnej a klinicky aplikovanej biochémie. Edited by Jozef Čársky. Prvé slovenské vydanie. Bratislava: Balneotherma s.r.o., 2015. 669 stran. ISBN 9788097015688. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Translated by Vladimír Benda - Martin Vejražka - Jiří Jonák. 1. české vydání. Praha: Grada, 2012. xiv, 498. ISBN 9788024729770. info
Teaching methods
Lectures
Assessment methods
Oral exam - students will draw two questions from Biochemistry I and two questions from Biochemistry II.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses

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Teacher's information
https://is.muni.cz/auth/el/1411/jaro2022/VLBC0422p/
The basic concepts and topics covered in the Biochemistry II exam are available in the Course-Related Instructions in IS MUNI.
The course is also listed under the following terms Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021.
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