aVLBC0422t Biochemistry II Laboratory Medicine - seminar

Faculty of Medicine
spring 2027
Extent and Intensity
0/1.3/0. 2 credit(s). Type of Completion: z (credit).
In-person direct teaching
Teacher(s)
doc. RNDr. Josef Tomandl, Ph.D. (seminar tutor)
doc. RNDr. Jiří Dostál, CSc. (seminar tutor)
MUDr. Michaela Králíková, Ph.D. (seminar tutor)
RNDr. Hana Paulová, CSc. (seminar tutor)
Mgr. Jiří Slanina, Ph.D. (seminar tutor)
prof. RNDr. Eva Táborská, CSc. (seminar tutor)
Mgr. Jana Gregorová, Ph.D. (assistant)
doc. PharmDr. Jiří Kos, Ph.D. (assistant)
doc. Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Iva Audy (assistant)
Ing. Bc. Hana Logerová, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: MUDr. Michaela Králíková, Ph.D.
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Prerequisites (in Czech)
aVLBC0321s Biochemistry I - seminar && aVLFY0321c Physiology I - practice && aVLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Abstract

The course introduces students to the significance of clinical biochemical examinations and their role in diagnosing, monitoring, and assessing a patient’s health status. It focuses on factors influencing laboratory test results, including the pre‑analytical, analytical, and post‑analytical phases, the importance of biological variability, and the principles of interpreting laboratory findings, including the evaluation of diagnostic effectiveness.

The course also provides a detailed overview of selected clinical biochemical tests, particularly those relevant to disorders of carbohydrate metabolism, liver and cardiovascular diseases, kidney function assessment, and the analysis of urine and cerebrospinal fluid.

Learning outcomes
Upon successful completion of the course, the student will be able to:
  • explain the significance and principles of clinical biochemical examinations, their execution, and the factors influencing laboratory results;
  • characterize the importance of biological variability and apply it when interpreting laboratory data and assessing the diagnostic effectiveness of tests;
  • describe and interpret major biochemical investigations in disorders of carbohydrate metabolism, liver diseases, and cardiovascular conditions;
  • describe and evaluate biochemical tests of kidney function, acid–base balance, as well as urine and cerebrospinal fluid analyses;
  • apply knowledge of laboratory parameters when solving model clinical situations.
Key topics
  • Factors influencing laboratory test results; pre‑analytical phase, blood collection and processing; reporting of results.
  • Analytical phase, validation of results, interpretation, reference change value, and diagnostic accuracy of laboratory tests.
  • Biochemical investigations in diabetes mellitus; laboratory monitoring of the disease.
  • Biochemical assessment of lipid metabolism; risk factors of atherosclerosis; laboratory diagnosis of myocardial infarction.
  • Biochemical testing in liver diseases; diagnosis of hyperbilirubinaemias and specific hepatic disorders.
  • Laboratory investigations of the gastrointestinal tract.
  • Urine collection and sampling; physical and chemical urine examination.
  • Assessment of glomerular filtration, tubular functions, and urolithiasis.
  • Examination of cerebrospinal fluid.
Study resources and literature
    required literature
  • Interactive Syllabus of the course in IS MU.
    recommended literature
  • Rajdl. D. a kol. Clinical biochemistry (e-book, formats: .pdf, .epub, .mobi) 1st ed. Prague, Karolinum Press, 2016, 426 s. ISBN: 978-80-246-3497-5. Download: https://karolinum.cz/en/books/rajdl-clinical-biochemistry-17096
Approaches, practices, and methods used in teaching
Seminar-based instruction, including discussion of selected topics and biochemical case studies
Method of verifying learning outcomes and course completion requirements
Credit. Conditions for giving the course-unit credit:
1) completion of all seminars and 2) completion of in-term tests.
Language of instruction
English
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught every week.
General note: Successful completion of the course is a condition for access to the exam in the course aVLBC0422p.
Teacher's information
Detailed information regarding teaching arrangements and course completion requirements is available in the Study Materials section of IS MU.
Consultations are possible upon personal arrangement with the teacher.
The course is also listed under the following terms spring 2023, spring 2024, spring 2025, spring 2026.
  • Enrolment Statistics (spring 2027, recent)
  • Permalink: https://is.muni.cz/course/med/spring2027/aVLBC0422t