aFAFY1_13 Physical Pharmacy

Faculty of Pharmacy
Spring 2026
Extent and Intensity
2/2/0. 5 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. Mgr. Jan Muselík, Ph.D. (lecturer)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (lecturer)
Ing. Marie-Anna Bajerová (seminar tutor)
doc. Mgr. Jan Muselík, Ph.D. (seminar tutor)
PharmDr. Jiří Zeman, Ph.D. (seminar tutor)
Dagmar Hudecová (assistant)
Ing. Adéla Sopoušková (assistant)
Aneta Škrháková, DiS. (assistant)
Guaranteed by
prof. PharmDr. Mgr. David Vetchý, Ph.D.
Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy
Timetable
Thu 14:40–16:20 18-122
  • Timetable of Seminar Groups:
aFAFY1_13/01: Mon 16. 2. to Fri 13. 3. each odd Friday 8:00–11:20 18-122, Mon 16. 3. to Fri 8. 5. each odd Friday 8:00–8:50 18-122, each odd Friday 8:50–11:20 18-138, M. Bajerová, J. Muselík, J. Zeman
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Abstract
The aim of the course is to make students familiar with basic knowledge of the physical chemistry, which constitutes part of the theoretical basis, necessary for understanding of processes delivered within disciplines in further stages of the study. Lectures are divided according to basic part of physical and colloid chemistry such as thermodynamics, kinetics of chemical reactions, behaviour of solutions, electrochemistry, phase equilibria, behaviour of phase interfaces, rheology, and colloidal systems. In seminars, students will get acquainted with physicochemical calculations, which are integral part of the knowledge required in the discipline. In laboratory exercises, students will learn the experimental techniques of physical chemistry.
Learning outcomes
After completing the course, the student will be able to:
– describe the thermodynamic nature of a number of pharmaceutical processes;
– describe the factors that influence the solubility and dissolution of substances;
– determine and describe kinetic parameters in pharmaceutical processes;
– identify and summarize important features of electrochemical and phase phenomena;
– apply rheological principles to a practical problem;
– identify and summarize important characteristics of colloidal systems.
Key topics
  • LECTURES:
  • Thermodynamics.
  • Solubility: solubility gas/liquid, liquid/liquid, solid/liquid, solubility of salts, poor soluble electrolytes, weak electrolytes and their salts.
  • Electrochemistry.
  • Phase equilibria.
  • Phase interfaces.
  • Diffusion, dissolution and their importance in drug development.
  • Kinetics: rates and orders of reactions. Influence of temperature and other factors on reaction rates. The importance of kinetics in formulation and development of pharmaceuticals.
  • Rheology: Newtonian systems, non-Newtonian systems, thixotropy, determination of rheologic properties, viscoelasticity, application in pharmacy.
  • Colloids.

  • SEMINARS:
  • States of matter and thermodynamics – calculations.
  • Phase equilibria, chemical kinetics and electrochemistry – calculations.
  • Written test – calculations.

  • LABORATORY EXERCISES:
  • Density determination by pycnometric method.
  • Partitioning of succinic acid in the system butanol-water.
  • Measurement of surface tension using the stalagmometric method.
  • Writtent test – theory from laboratory exercises.
Study resources and literature
    recommended literature
  • HAMMES, Gordon G. and Sharon HAMMES-SCHIFFER. Physical chemistry for the biological sciences. Second edition. Hoboken, NJ: Wiley, 2015, 1 online. ISBN 9781118859148. URL info
  • Martin's physical pharmacy and pharmaceutical sciences : physical chemical and biopharmaceutical principles in the pharmaceutical sciences. Edited by Patrick J. Sinko - Yashveer Singh. Sixth edition. Philadelphia: Wolters Kluwer, 2011, viii, 659. ISBN 9781609134020. info
Approaches, practices, and methods used in teaching
Lectures, seminars and laboratory exercises.
Method of verifying learning outcomes and course completion requirements
Preparation of laboratory reports, continuous written tests, and a final written examination.
Language of instruction
English
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/pharm/spring2026/aFAFY1_13