aFAGE1_16 Applied Genetics

Faculty of Pharmacy
Spring 2026

The course is not taught in Spring 2026

Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. MVDr. RNDr. Petr Hořín, CSc. (lecturer)
PharmDr. Mgr. Alžběta Kružicová, Ph.D. (lecturer)
Guaranteed by
prof. MVDr. RNDr. Petr Hořín, CSc.
Department of Molecular Pharmacy – Departments – Faculty of Pharmacy
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Abstract
Theoretical principles and practical applications of genetics in pharmacy are taught. Special attention is paid to genomics and its importance for new drug development, to genetics of disease, geentics of host and pathogen interactions, genetic variability in reactions to pharmacotherapy. Genetics of laboratory animals represents a special topic of the course.
Learning outcomes
Students will be able to use the acquired knowledge in related curricular subjects and eventually, they will be able to use it in understanding principles of drug action and in interpreting them for themselves and for their clients.
Key topics
1. Genome and its structure. Microbiome and its importance for pharmacy.Genetic polymorphism: definition, origins, types and practical applications in biomedicine. 2. Gene and methods of its identification. Genetics of qualitative and quantitative traits, methods of their analysis; applications in biomedicine. 3. Application of genetics in pharmacy: pharmacogenetics, important pharmacogenetic polymorphisms and applications in pharmacotherapy. 4. Genomics and its applications in pharmacy: pharmacogenomics, development of new drugs, precision medicine. 5. Mutations and mutagens. Types of mutations, their consequences. Mutagens in the environment. Drugs as potential mutagens. 6. Drugs in pregnancy from the genetic perspective. 7. Inherited disease in humans: Mendelian and non-Mendelian diseases. Human monogeneic diseases: modes of inheritance. 8. Inherited disease in humans: complex diseases and their genetic analysis. 9. Inherited disease in humans: genetic counselling, genetic diagnostics, prenatal and preimplantation diagnostics. 10. Oncogenetics: principles and applications. 11. Genetic susceptibility to disease, importance for precision medicine. 12. Human immunogenetics and its applications. Vaccinomics and genetics of vaccination. 13. Genetics of laboratory animals.
Study resources and literature
    recommended literature
  • PIERCE, Benjamin A. Genetics : a conceptual approach. Seventh edition. New York: Macmillan international, higher education, 2020, xxviii, 82. ISBN 9781319308315. info
Approaches, practices, and methods used in teaching
Interactive lectures.
Method of verifying learning outcomes and course completion requirements
Written examinations. Assessment criteria: capability to present an overview of a topic in a structured way, capability to explain its principles and a minimal factographic knowledge neede for complying with the previous criteria.
Language of instruction
English
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