PřF:C2200 Chemical synthesis - lab. - Course Information

C2200 Chemical synthesis - laboratory

Extent and Intensity

0/0/8. 8 credit(s). Type of Completion: graded credit.

Teacher(s)

RNDr. Slávka Janků, Ph.D. (seminar tutor)

Guaranteed by

prof. RNDr. Jiří Pinkas, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science

Prerequisites

( C1100 Laboratorní technika || C1100b Laboratorní technika )&&( C1020 General Chemistry || C1021 General Chemistry )&& C1040 General Chemistry-sem.
Basic knowledge of general, inorganic and organic chemistry. Writing chemical equations, stoichiometric calculations, and calculations of solution concentration and mixing will be used extensively.

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 14 fields of study the course is directly associated with, display

Course objectives

Basic laboratory course in preparative chemistry. Covers syntheses, properties and structures of simple inorganic and organic compounds, such as oxides, halides and other salts, acids and their functional derivatives, and complexes. At the end of the course students should be able to explain the principles that underpin selected synthetic processes, and why specialist techniques are required for their preparation.

Syllabus

1. Introduction, safety rules, laboratory notebook, worked example of experiment calculations. Requirements for passing the course. Nomenclature of inorganic and organic compounds. Chemical literature.

2. Ethyl 3-oxobutanoate ethylenacetale. AN mechanism to C=O, azeotropic and vacuum distillation, work with rotary evaporator.

3. Synthetic routes to salts. Copper(II) sulfate. Copper(I) iodide. Mohr's salt.

4. Synthetic routes to acids and halides. Orthoboric acid. Tin(IV) iodide.

5. 4,4-diphenyl-4-hydroxy-2-butanone ethylenacetale. Extraction, work with rotary evaporator, recrystallization.

6. Synthetic routes to coordination compounds. Hexaaquacobalt(II) chloride.

7. Hexaamminecobalt(III) chloride. Pentaammine-chlorocobalt(III) chloride. Potassium tetraperoxochromate(V).

8. Synthetic routes to salts. Metal acetylacetonate complexes. Thin-layer chromatography.

9. 3-Nitroacetophenone. SEAr mechanism, recrystallization, IR spectroscopy.

10. Benzoic acid. AN to C=O, work with anhydrous solvents, extraction, sublimation.

11. Synthetic routes to oxides. Boric oxide. Trimethylborate. Amonnium tetrathiomolybdate(VI).

12. Ethyl-acetate. Esterifikace, distillation.

13. 2-Hydroxy-5-methyl-2'-nitroazobenzene. Diazotization and diazonium coupling, recrystallization, TLC.

14. Final test, make-up class, lab cleaning.

Literature

• Masarykova univerzita. Přírodovědecká fakulta. Návody ke cvičení z anorganické chemie. Brno, Masarykova univerzita, 2006, 80 s.
• NOVÁČEK, Eduard and Milan POTÁČEK. Laboratorní technika ke cvičení z metod organické chemie. Edited by Slávka Janků. 1. vyd. Brno: Masarykova univerzita, 1997, 91 s. ISBN 8021015004. info
• KLIKORKA, Jiří. Úvod do preparativní anorganické chemie. 3. vyd. Praha: SNTL - Nakladatelství technické literatury, 1974, 373 s. info
• TANAKA, John and Steven L. SUIB. Experimental Methods in Inorganic Chemistry. New Jersey: Prentice Hall, 1999, 393 pp. ISBN 0-13-841909-4. info

Assessment methods

The course can also be completed outside the examination period. The course is taught annually. The course is taught: every week.

Language of instruction

Czech

Further comments (probably available only in Czech)

The course is taught annually.
The course is taught every week.

Listed among pre-requisites of other courses

• C2720 Organic Chemistry - laboratory course
  (C4221||C1100||C1600)&&!C2200  
• C6190 Advanced laboratory course of inorganic chemistry.
  C2200  

• Enrolment Statistics (Spring 2011 - only for the accreditation, recent)
  
• Permalink: https://is.muni.cz/course/sci/spring2011-onlyfortheaccreditation/C2200