F8390 Metalloproteins: structure and function

Faculty of Science
spring 2012 - acreditation

The information about the term spring 2012 - acreditation is not made public

Extent and Intensity
1/0. 1 credit(s) (plus extra credits for completion). Type of Completion: k (colloquium).
Teacher(s)
prof. Dr. Jiří Kozelka, PhD. (lecturer)
Guaranteed by
prof. RNDr. Josef Humlíček, CSc.
Department of Condensed Matter Physics – Physics Section – Faculty of Science
Contact Person: prof. Dr. Jiří Kozelka, PhD.
Supplier department: Department of Condensed Matter Physics – Physics Section – Faculty of Science
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
  • Biophysics (programme PřF, M-FY)
  • Biophysics (programme PřF, N-FY, specialization Molekulární biofyzika)
Course objectives
The main objective of the course is to provide the students with the ability to
- name the occurrence of transition metal complexes inside metalloproteins
- disscuss how inorganic chemists model the active sites of metalloproteins
- apply diverse spectroscopic methods in the study of metal active sites of metalloproteins
- disscuss examples of how nature uses the same active site for different purposes and also the mechanisms of the principal oxygen carriers the nature developed.
Syllabus
  • 1. Introduction
  • 1.1. Metal ions: Functions in Biological Chemistry
  • 1.2. Some fundamental metal sites in metalloproteins
  • 2. Metalloproteins reacting with oxygen
  • 2.1. General considerations
  • 2.2. Oxygen transport proteins & Oxygenases
  • 2.2.1. Hemoglobin, Myoglobin & Cytochrome P450
  • Insert: Introduction to inorganic spectroscopy
  • Insert: Important ligands in metalloproteins
  • 2.2.2. Hemocyanin & Tyrosinase
  • 2.2.3. Hemerythrin & Ribonucleotide reductase & Methane monooxygenase diiron subunits
  • 3. Examples of other active sites in metalloproteins
Literature
  • LIPPARD, Stephen J. and Jeremy M. BERG. Principles of bioinorganic chemistry. Mill Valley: University Science Books, 1994, 411 s. ISBN 0-935702-73-3. info
Teaching methods
lectures, class discussion,
Assessment methods
1 Mid-term written test (not obligatory but highly recommended since it will give an impression of final test)
1 Final written test
A satisfactory accomplishment of the test will be required for the 2 credits given for this course.
Language of instruction
English
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
Teacher's information
http://physics.muni.cz/biophys/vyuka.shtml
The course is also listed under the following terms Spring 2011 - only for the accreditation, Spring 2009, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, spring 2018, Spring 2019, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.