PřF:C2138 Advanced bioinformatics - Course Information

C2138 Advanced bioinformatics

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

Mgr. Lenka Malinovská, Ph.D. (lecturer)
prof. RNDr. Michaela Wimmerová, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Michaela Wimmerová, Ph.D.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science

Timetable

Tue 14:00–15:50 C04/118

Prerequisites

C2135 Bioinformatics for practice && NOW( C2139 Advanced bioinformatics - seminary )
C2130 Introduction to chemoinformatics and bioinformatics C2135

Course Enrolment Limitations

The course is offered to students of any study field.

Course objectives

At the end of the course students should be able to:
understand and explain basic terms in the field of bioinformatics;
compare large databases of sequences and extract data;
predict 2D and 3D structure of proteins and nucleic acids;
predict posttranslational modifications;

Learning outcomes

At the end of the course students should: 1) Obtain basic knowledge of bioinformatics. Students should be able to: 1) Process bioinformational data. 2) Predict basic properties of biomacromolecules. 3) Utilize bioinformational tools for solving of biological problems.

Syllabus

• 1-2) basic terms in bioinformatics, methods, tools.
  3) Study of gene expression using bioinformatics. Promoter prediction, non-coding parts of nucleic acids, transcription factors.
  4) Genomes annotation. Automation, verification, error sources..
  5) Phylogenetic analysis, phylogeny trees, rules.
  6) Posttranslational modifications, importance. Predictive algorithms..
  7) Bioinformatic potential of saccharides, glycome.
  8) Protein data bank (PDB) – tools, structure validation, error sources.
  9) Prediction tool for nucleic acids. 2D, 3D structure, repetitions, importance.
  10) Primer design, mutagenesis. Different approaches in primer design for different purposes.Mutagenesis in vitro and in silico.
  11) Alignment of metabolic pathways, metabolome.
  12) Virtual screening in bioinformatics, unics of databases, binding sites of proteins.

Literature

• HODGMAN, T. Charlie, Andrew FRENCH and David R. WESTHEAD. Bioinformatics. 2nd ed. Milton Park, Abingdon: Taylor & Francis, 2010, x, 340. ISBN 9780415394949. info
• ZVELEBIL, Marketa J. and Jeremy O. BAUM. Understanding bioinformatics. New York, N.Y.: Garland Science, 2008, xxiii, 772. ISBN 9780815340249. info
• MOUNT, David W. Bioinformatics : sequence and genome analysis. 2nd ed. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press, 2004, xii, 692. ISBN 0879697121. info

Teaching methods

lectures with practical demonstrations

Assessment methods

written exam

Language of instruction

Czech

Follow-Up Courses

• C2139 Advanced bioinformatics - seminary

Further Comments

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

• C2139 Advanced bioinformatics - seminary
  NOW(C2138)  

• Enrolment Statistics (spring 2018, recent)
  
• Permalink: https://is.muni.cz/course/sci/spring2018/C2138