Dose adjustment in renal insufficiency, nephro-toxicity of drugs
Kristýna Nosková
Subchapter list
Chapter intro
Prerequisites and corequisites:
- Processes of renal elimination of drugs, evaluation of renal function, estimation of glomerular filtration rate
- Definitions, causes, manifestations, diagnostic criteria (AKIN, RIFLE) of acute kidney injury (AKI)
- Definition, causes, manifestations, diagnostic criteria, risk factors of chronic kidney disease (CKD)
- Pharmacokinetic processes and parameters (bioavailability, volume of distribution, clearance, biological half-life…)
At first, try to answer the following questions or to find the answer:
- Which classifications do we use for AKI and which for CKD?
- How could the pharmacokinetics of drugs be affected in AKI? And how in CKD?
- Do you know any drugs that are eliminated exclusively by the kidneys?
- Do we always have to reduce the dosage of drugs in patients with impaired renal function?
- Do you know any nephrotoxic drugs?
- Do you know some procedures to prevent nephrotoxicity of drugs?