CS

LF:VSPF0521c Pathophysiol. I - practice. - Course Information

VSPF0521c Pathological physiology I - practice

Faculty of Medicine
Autumn 2017
Extent and Intensity
0/3/0. 4 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. MUDr. Julie Dobrovolná, Ph.D. (seminar tutor)
MUDr. Kamil Ďuriš, Ph.D. (seminar tutor)
MUDr. Michal Jurajda, Ph.D. (seminar tutor)
prof. MUDr. Kateřina Kaňková, Ph.D. (seminar tutor)
Mgr. Andrea Knight, Ph.D. (seminar tutor)
MUDr. Jan Máchal, Ph.D. (seminar tutor)
doc. RNDr. Michal Masařík, Ph.D. (seminar tutor)
Mgr. Lukáš Pácal, Ph.D. (seminar tutor)
doc. RNDr. Monika Pávková Goldbergová, Ph.D. (seminar tutor)
Dipl. Ing. Martin Piskáček, Dr. rer. nat. (seminar tutor)
prof. MUDr. Anna Vašků, CSc. (seminar tutor)
MUDr. Jaromír Gumulec, Ph.D. (assistant)
Věra Ježková (assistant)
Supervisor
prof. MUDr. Anna Vašků, CSc.
Department of Pathological Physiology - Theoretical Departments - Faculty of Medicine
Supplier department: Department of Pathological Physiology - Theoretical Departments - Faculty of Medicine
Prerequisites
VSFY0422p Physiology II - lecture && ( VSBC041p Biochemistry II -l || VSBC0422p Biochemistry II -l ) && VSAN0333p Anatomy III - lec. && VSHE0322p Histology and embryology II -l && ( VSLT0221s Bas. Med. Terminol. II -s || VSLT011s Bas. Med. Terminology -l ) && VSET021 Medical Ethics I && ZC041 Handling chemical substances
Physiology, biochemistry
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
Fields of study the course is directly associated with
Course objectives
The student will be trained for assuming these knowledge and skills:
Principles and ethics of experimental use of laboratory animals, basic surgical skills, general principles of work with lab. animals - explorative laparotomy
Pathophysiology of blood and bone marrow disorders, haematological findings in selected blood disorders
Statistical analysis of experiments (introduction)
Exp. induced acute radiation syndrome in lab. animal – haematological consequences
Essential hypertension, resting and ambulatory blood pressure (and heart rate) measurements, postural changes, effect of isometric and aerobic exercise
Pathophysiology of ventilation disorders and pulmonary gas exchange – spirometry and hyperoxic test
Secondary hypertension, exp. induced renal ischemia – quantification of renal rennin expression
Conductive disorders, demonstration of selected types of arrhythmias
ECG monitoring of exp. induced arrhythmias in lab. animal
Exp. induced acute renal insufficiency in lab. animal – measurement of GFR based on kinetics of renal inulin excretion
Exp. induced renal failure - peritoneal dialysis in lab. animal
Learning outcomes
Student applies the basic knowledge of biostatistics to explain the structure of reference intervals ;
Student will describe the influence of ionizing radiation on the body at the level of molecular, cellular, tissue, and they justify the time dynamics of the system;
Student will describe changes in blood cell counts dynamics in the acute radiation disease ;
Student makes a distinction between deterministic and stochastic effects of ionizing radiation and their practical implications ;
Student will explain the principle of ultrasound and dopplerometric examination of the blood vessels, the underlying pathology of peripheral vasculature (venous valvular insufficiency, ischemia, short circuits, and steal syndromes);
Student interprets the continuous ECG monitoring in experimental animals for several pathological conditions ;
Student distinguishes ECG records most commonly occurring arrhythmias (sinus arrhythmia, SVES, atrial fibrillation, atrial flutter, AVRT, AV blockade blockade, ventricular tachycardia, torsades de pointes, ventricular fibrillation) ;
Student demonstrates the basic static and dynamic parameters surveyed during the spirometric examination and their relationship to pulmonary diseased;
Student will describe the development of renal ischemia in experimental animal model;
Student will explain the determination of the glomerular filtration rate, depending on the curve of concentration of inulin excretion by the kidneys, while discussing the use of clearance of other substances (creatinine, PAH) ;
Student demonstrates the emergence of renovascular hypertension in the Goldblatt´s model, renal artery stenosis, the difference between unilateral and bilateral stenosis, the role of the RAAS and the expansion of the volume due to hypertension diagnosis;
Syllabus
  • Introduction, health & safety in the lab, principles and ethics of experimental use of laboratory animals, basic surgical skills, general principles of work with lab. animals & explorative laparotomy
  • Statistical analysis of experiments (introduction)
  • Principles of ECG analysis, demonstration of selected pathological ECG patterns
  • Conductive disorders (seminar), ECG monitoring of exp. induced arrhythmias in lab. animal
  • Principles and demonstration of peripheral blood flow examination using ultrasonography
  • Cell cycle, oncogenes and supressor genes, cancer development. (seminar)
  • Exp. induced acute radiation syndrome in lab. animal – haematological consequences
  • Secondary hypertension (seminar), exp. induced renal ischemia (part 1)
  • Pathophysiology of ventilation disorders and pulmonary gas exchange – spirometry
  • Essential hypertension (seminar), resting and ambulatory blood pressure (and heart rate) measurements, postural changes, effect of isometric and aerobic exercise
  • Exp. induced renal ischemia – detection of renal renin expression (part 2)
  • Exp. induced acute renal insufficiency in lab. animal – measurement of GFR based on kinetics of renal inulin excretion
  • Exp. induced renal failure - peritoneal dialysis in lab. animal Acidbase balance (seminar), tests, credits
Literature
Teaching methods
practical exercises in labs, discussion to the given topics, video with comments
Assessment methods
Practicals are compulsory. The only permited reason for not attending is a student's sick leave. Student can - with tutor's approval - substitute the particular practical in a given week with another group in case he/she has a justifiable reason for it. Student's participation in the practicals throughout the term is certified by a credit. Students can be given written tests or individual home work by tutor's throughout the term. Students have to be wearing lab coats during the practicals.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
General note: Studenti opakující 3. ročník nemusejí znovu absolvovat praktika, budou jim uznány zápočty, ke zkoušce mohou přijít v nejbližším zkouškovém období.
The course is also listed under the following terms Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016.
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