aVLFA0721c Farmakologie I - cvičení

Lékařská fakulta
podzim 2020
Rozsah
0/3/0. 45. 1 kr. Ukončení: z.
Vyučující
doc. MUDr. Regina Demlová, Ph.D. (cvičící)
doc. PharmDr. Jan Juřica, Ph.D. (cvičící)
Mgr. Petra Amchová, Ph.D. (cvičící)
doc. RNDr. Ladislava Bartošová, Ph.D. (cvičící)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (cvičící)
Mgr. Jana Merhautová, Ph.D. (cvičící)
Mgr. Kristýna Nosková, Ph.D. (cvičící)
MUDr. Jana Nováková, Ph.D. (cvičící)
MUDr. Jana Pistovčáková, Ph.D. (cvičící)
PharmDr. Jitka Rychlíčková, Ph.D. (cvičící)
Mgr. Barbora Říhová, Ph.D. (cvičící)
PharmDr. Lenka Součková, Ph.D. (cvičící)
Filip Šiška (cvičící)
PharmDr. Ondřej Zendulka, Ph.D. (cvičící)
Renata Bláblová (pomocník)
Květoslava Sedlářová (pomocník)
Garance
doc. MUDr. Regina Demlová, Ph.D.
Farmakologický ústav - Teoretická pracoviště - Lékařská fakulta
Kontaktní osoba: doc. Mgr. MVDr. Leoš Landa, Ph.D.
Dodavatelské pracoviště: Farmakologický ústav - Teoretická pracoviště - Lékařská fakulta
Předpoklady
aVLPF0622c Patologická fyziol. II - cv && aVLPA0622c Patologie II - cv.
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
The aims of the course are:
to recognize the basic pharmacological terminology and legislation related to the use of drugs and thei prescription
to understand to differences between single drug dosage forms
to understand to the prescription of drugs
to understand to the basics of pharmacokinetics
to understand to the basic facts about the discussed drugs
Výstupy z učení
At the end of the course the student knows:
single pharmacoterapeutical drug clases
single drug dosage forms
the modes of action, adverse reactions and basic indications of single drugs of discussed drugs
how to prescribe selected medical preparation or a drug in particular drug dosage form
Osnova
  • VLFA07212c - Pharmacology I - practical lessons

    General medicine

    Autumn semester 2019

  • 23. 9. – 27. 9. 2019
  • Topic 1: INFORMATION ON DRUGS
  • Course content: Organisation of practical courses and lectures, system of evaluation. Repetition of basic pharmacologic terminology. Sub-branches of pharmacology. Sources of information concerning drugs and recommended textbooks. Work with relevant databases (Brevíř, SÚKL, EMA, AISLP), ATC classification.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 1, exam question outlines.
  • 30. 9. – 4. 10. 2019
  • Topic 2: PRESCRIPTION OF MEDICAL PRODUCTS I
  • Course content: General rules of drug prescription. Prescription of the ready-made preparations, drug dosage forms.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 2. Exam question outlines. Drug dosage forms from the textbook. Legislation of the Czech Republic related to drugs and their prescription (selected section of the Act No. 378/2007 Coll., on Pharmaceuticals and on Amendments to Some Related Acts).
  • 7. 10. – 11. 10. 2019
  • Topic 3: PRESCRIPTION OF MEDICAL PRODUCTS II, ROUTES OF DRUG ADMINISTRATION
  • Course content: Brief characteristics of the individual drug dosage forms. Clinical significance of the way of drug administration.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 3. Exam question outlines. Information in drug databases - SÚKL (www.sukl.cz), EMA and Drugs.com.
  • 14. 10. – 18 .10. 2019
  • Topic 4: PRINCIPLES OF PHARMACOKINETICS
  • Course content: Pharmacokinetic processes, parameters and calculations.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 4. Exam Qustion outlines.
  • 21. 10. – 25. 10. 2019
  • Topic 5: PRINCIPLES OF APPLIED PHARMACOKINETICS
  • Course content: Pharmacokinetic case reports, simulation of plasma concentrations course, dosage optimalization and use of software tools, factors affecting course and value of drug´s plasma concentrations.
  • Self-studying preparation for practical lessons: Materials for the Lectures No. 4 and 5.Exam question outlines.
  • 28. 10. – 1. 11. 2019
  • Topic 6: PHARMACODYNAMICS
  • MULTIPLE-CHOICE TEST 1 (Topics 1-5).
  • Course content: Mechanisms of drug effects - classification, examples. Dose-response curves.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 6.Exam question outlines.
  • 4. 11. – 8. 11. 2019
  • Topic 7: PHARMACOVIGILANCE, ADVERSE DRUG REACTIONS
  • Course content: Classification and characteristics of adverse drug effects. Pharmacovigilance in clinical practice, sources of current information on drug safety.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 7. Exam question outlines.
  • 11. 11. – 15. 11. 2019
  • Topic 8: FACTORS AFFECTING DRUG EFFECTS
  • Course content: Pharmacotherapy in childhood, in pregnancy, in breastfeeding women, in elderly. Beer's list, STOPP _ START, FORTA, PRRL. Pharmacogenetics.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 8. Exam question outlines. Pharmacogenetics - materials in IS.
  • 18. 11. – 22. 11. 2019
  • Topic 9: PHARMACOLOGY OF SYMPATHETIC NERVOUS SYSTEM
  • Course content: Drugs affecting sympathetic nervous system - classification, basic pharmacological characteristics.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 9. Exam question outlines. Pathophysiological bases - ANS, neurotransmitters (their synthesis and degradation), receptors of the sympathetic nervous system (alpha, beta) and parasympathetic nervous system (nicotinic, muscarinic) and their subtypes and organ distribution. Systems of second messengers. Pharmacodynamics, both direct and indirect mechanisms of action.
  • 25. 11. – 29. 11. 2019
  • Topic 10: PHARMACOLOGY OF PARASYMPATHETIC NERVOUS SYSTEM
  • Course content: Drugs affecting parasympathetic nervous system - classification, basic pharmacological characteristics. Spasmolytic drugs.
  • Self-studying preparation for practical lessons: Materials for the Lectures No. 9. Spasmolytic drugs. Exam questions outlines.
  • 2. 12. – 6. 12. 2019
  • Topic 11: ANALGESICS
  • MULTIPLE-CHOICE TEST 2 (Topics 6-10).
  • Course content: MULTIPLE-CHOICE TEST (6th - 10th week). Basic pharmacological characteristics of opioid and non-opioid analgesic drugs, antirheumatoid drugs and drugs used in gout.
  • Self-studying preparation for practical lessons: Materials for the Lectures No. 10 and 11, Exam question outlines. Antirheumatics and anti-gout medications - study material in IS.
  • 9. 12. – 13. 12. 2019
  • Topic 12: ANAESTHETIC DRUGS
  • PRESCRIPTION TEST
  • Course content: Basic pharmacological characteristics of general and local anaesthetic drugs. Premedication prior to general anaesthesia.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 12. Exam question outlines. Muscle relaxants (IS).
  • 16. 12. – 20. 12. 2019
  • Topic 13: PHARMACOTHERAPY OF DIABETES MELLITUS
  • Course content: Repetition of anti-diabetic drugs - basic pharmacological characteristics. Drugs used in therapy of specific and acute conditions in diabetology. Combinations of insulins, insulin regimens.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 13. Exam question outlines.
  • 6. 1. – 10. 1. 2020
  • Topic 14: SEX HORMONES
  • Course content: Endocrine therapy, hormone replacement therapy, hormonal contraceptive drugs.
  • Self-studying preparation for practical lessons: Materials for the seminar No. 14. Exam question outlines.Uterotonics and tocolytics.
  • 13. 1. – 17. 1. 2020
  • Topic 15: GLUCOCORTICOIDS, THYROID HORMONES
  • MULTIPLE-CHOICE TEST 3 (Topics 11-14).
  • Course content: Repetition of basic pharmacological characteristics of glucocorticoids and thyroid hormones.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 15. Exam question outlines.
Literatura
    povinná literatura
  • Practicals in Pharmacology, 2009, Náhradní obsah: http://portal.med.muni.cz/article-491-practicals-in-pharmacology.html
  • http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
  • RANG, H. P. Rang & Dale's pharmacology. 8th ed. [Edinburgh]: Churchill Livingstone, 2016. xv, 760. ISBN 9780702053627. info
    doporučená literatura
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015. xi, 664. ISBN 9781451191776. info
    neurčeno
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014. xvii, 552. ISBN 9780702051432. info
  • Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • LÜLLMANN, Heinz, Lutz HEIN a Klaus MOHR. Color atlas of pharmacology. Translated by Detlef Bierger, Illustrated by Jürgen Wirth. 4th ed. Stuttgart: Thieme, 2011. x, 393. ISBN 9783137817048. info
  • Pharmacology. Edited by Michelle Alexia Clark. 5th ed. Baltimore: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2012. xii, 612. ISBN 9781451113143. info
Záložky
https://is.muni.cz/ln/tag/LF:aVLFA0721c!
Výukové metody
practicals, class discussion

Only 1 absence from practical lessons is possible.
Metody hodnocení
3 continuous multiple-choice tests (time limit: 15 min) and 1 prescription test in a paper form. MCQ tests will not be repeated. The prescription test can be repeated only twice.

Each multiple-choice test contains 15 questions. The number of correct answers is given. Student gets 1 point for each completely correct answer, i.e. maximum 15 points for each multiple-choice test; total 45 points for all three MCQ tests.

The prescription test consists of two read-made preparations. For both preparations, the active substance, the drug dosage form and the number of original packages to be prescribed will be listed. The prescription handbook will be available for the test.

To obtain credits, the student has to pass the prescription test successfully and also get at least 6 points from each single multiple-choice test and at least 20 points (minimum) from all three MCQ tests.

Note: Together with the new accreditation of the Pharmacology subject for students of General Medicine, a system of continuous assessment of the student was introduced, when the results achieved in multiple-choice tests in practical lessons and colloquium will be taken into account and included in the final mark from the subject.
Vyučovací jazyk
Angličtina
Informace učitele
Course Contents:

INTRODUCTION, TERMINOLOGY, DOSES, PHARMACOLOGICAL CALCULATIONS
GENERAL RULES OF THE DRUG PRESCRIPTION
FLUID DRUG DOSAGE FORMS FOR THE EXTERNAL USE, ORAL AND PARENTERAL USE. GASEOUS DRUG DOSAGE FORMS
SOLID DRUG DOSAGE FORMS. SOFT AND MELTING DRUG DOSAGE FORMS
ROUTES OF DRUG ADMINISTRATION
INTRODUCTION TO PHARMACOKINETICS, PRINCIPLES, PARAMETERS
PHARMACOKINETIC INTERACTIONS. THERAPEUTIC DRUG MONITORING
PHARMACODYNAMICS
ADVERSE DRUG REACTIONS
FACTORS AFFECTING DRUG EFFECTS
PHARMACOLOGY OF THE SYMPATHETIC NERVOUS SYSTEM SYMPATHOMIMETICS, SYMPATHOLYTICS
PHARMACOLOGY OF THE PARASYMPATHETIC NERVOUS SYSTEM CHOLINERGIC DRUGS, SPASMOLYTICS
PHARMACOLOGY OF ENDOCRINE SYSTEM
GLUCOCORTICOIDS
ANTI-DIABETIC DRUGS
SEX HORMONES, UTEROTONICS, TOCOLYTICS
ANALGESIC DRUGS
ANTIRHEUMATOID DRUGS
DRUGS USED IN GOUT
ANAESTHETIC DRUGS
MUSCLE RELAXANTS
Další komentáře
Předmět je vyučován každoročně.
Výuka probíhá každý týden.
Předmět je zařazen také v obdobích podzim 2017, podzim 2018, podzim 2019.