aVLFA0721c Farmakologie I - cvičení

Lékařská fakulta
podzim 2020
Rozsah
0/3/0. 45. 1 kr. Ukončení: z.
Vyučováno prezenčně.
Vyučující
doc. MUDr. Regina Demlová, Ph.D. (cvičící)
doc. PharmDr. Jan Juřica, Ph.D. (cvičící)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (přednášející)
Mgr. Petra Amchová, Ph.D. (cvičící)
doc. RNDr. Ladislava Bartošová, Ph.D. (cvičící)
Mgr. Jana Kubátová, Ph.D. (cvičící)
Mgr. Kristýna Nosková, Ph.D. (cvičící)
MUDr. Jana Nováková, Ph.D. (cvičící)
MUDr. Jana Pistovčáková, Ph.D. (cvičící)
PharmDr. Jitka Rychlíčková, Ph.D. (cvičící)
Mgr. Barbora Říhová, Ph.D. (cvičící)
PharmDr. Lenka Součková, Ph.D. (cvičící)
doc. PharmDr. Ondřej Zendulka, Ph.D. (cvičící)
Renata Bláblová (pomocník)
Květoslava Sedlářová (pomocník)
Garance
doc. MUDr. Regina Demlová, Ph.D.
Farmakologický ústav - Teoretická pracoviště - Lékařská fakulta
Kontaktní osoba: doc. Mgr. MVDr. Leoš Landa, Ph.D.
Dodavatelské pracoviště: Farmakologický ústav - Teoretická pracoviště - Lékařská fakulta
Rozvrh seminárních/paralelních skupin
aVLFA0721c/30: Čt 15. 10. 16:00–18:30 A19/229, Čt 22. 10. 16:00–18:30 A19/229, Čt 29. 10. 16:00–18:30 A19/229, Čt 5. 11. 16:00–18:30 A19/229, Čt 12. 11. 16:00–18:30 A19/229, Čt 19. 11. 16:00–18:30 A19/229, Čt 26. 11. 16:00–18:30 A19/229, Čt 3. 12. 16:00–18:30 A19/229, Čt 10. 12. 16:00–18:30 A19/229, Čt 17. 12. 16:00–18:30 A19/229, Čt 7. 1. 16:00–18:30 A19/229, Čt 14. 1. 16:00–18:30 A19/229, Čt 21. 1. 16:00–18:30 A19/229, Čt 28. 1. 16:00–18:30 A19/229, Čt 4. 2. 16:00–18:30 A19/229, J. Pistovčáková
aVLFA0721c/31: St 14. 10. 13:00–15:30 A19/229, St 21. 10. 13:00–15:30 A19/229, St 4. 11. 13:00–15:30 A19/229, St 11. 11. 13:00–15:30 A19/229, St 18. 11. 13:00–15:30 A19/229, St 25. 11. 13:00–15:30 A19/229, St 2. 12. 13:00–15:30 A19/229, St 9. 12. 13:00–15:30 A19/229, St 16. 12. 13:00–15:30 A19/229, St 6. 1. 13:00–15:30 A19/229, St 13. 1. 13:00–15:30 A19/229, St 20. 1. 13:00–15:30 A19/229, St 27. 1. 13:00–15:30 A19/229, St 3. 2. 13:00–15:30 A19/229, J. Rychlíčková
aVLFA0721c/32: Pá 16. 10. 13:00–15:30 A19/229, Pá 23. 10. 13:00–15:30 A19/229, Pá 30. 10. 13:00–15:30 A19/229, Pá 6. 11. 13:00–15:30 A19/229, Pá 13. 11. 13:00–15:30 A19/229, Pá 20. 11. 13:00–15:30 A19/229, Pá 27. 11. 13:00–15:30 A19/229, Pá 4. 12. 13:00–15:30 A19/229, Pá 11. 12. 13:00–15:30 A19/229, Pá 18. 12. 13:00–15:30 A19/229, Pá 8. 1. 13:00–15:30 A19/229, Pá 15. 1. 13:00–15:30 A19/229, Pá 22. 1. 13:00–15:30 A19/229, Pá 29. 1. 13:00–15:30 A19/229, Pá 5. 2. 13:00–15:30 A19/229, J. Pistovčáková
aVLFA0721c/33: Po 12. 10. 16:00–18:30 A19/229, Po 19. 10. 16:00–18:30 A19/229, Po 26. 10. 16:00–18:30 A19/229, Po 2. 11. 16:00–18:30 A19/229, Po 9. 11. 16:00–18:30 A19/229, Po 16. 11. 16:00–18:30 A19/229, Po 23. 11. 16:00–18:30 A19/229, Po 30. 11. 16:00–18:30 A19/229, Po 7. 12. 16:00–18:30 A19/229, Po 14. 12. 16:00–18:30 A19/229, Po 4. 1. 16:00–18:30 A19/229, Po 11. 1. 16:00–18:30 A19/229, Po 18. 1. 16:00–18:30 A19/229, Po 25. 1. 16:00–18:30 A19/229, Po 1. 2. 16:00–18:30 A19/229, L. Součková
aVLFA0721c/34: Út 13. 10. 16:00–18:30 A19/326, Út 20. 10. 16:00–18:30 A19/326, Út 27. 10. 16:00–18:30 A19/326, Út 3. 11. 16:00–18:30 A19/326, Út 10. 11. 16:00–18:30 A19/326, Út 24. 11. 16:00–18:30 A19/326, Út 1. 12. 16:00–18:30 A19/326, Út 8. 12. 16:00–18:30 A19/326, Út 15. 12. 16:00–18:30 A19/326, Út 5. 1. 16:00–18:30 A19/326, Út 12. 1. 16:00–18:30 A19/326, Út 19. 1. 16:00–18:30 A19/326, Út 26. 1. 16:00–18:30 A19/326, Út 2. 2. 16:00–18:30 A19/326, L. Landa
aVLFA0721c/35: Út 13. 10. 16:00–18:30 A19/229, Út 20. 10. 16:00–18:30 A19/229, Út 27. 10. 16:00–18:30 A19/229, Út 3. 11. 16:00–18:30 A19/229, Út 10. 11. 16:00–18:30 A19/229, Út 24. 11. 16:00–18:30 A19/229, Út 1. 12. 16:00–18:30 A19/229, Út 8. 12. 16:00–18:30 A19/229, Út 15. 12. 16:00–18:30 A19/229, Út 5. 1. 16:00–18:30 A19/229, Út 12. 1. 16:00–18:30 A19/229, Út 19. 1. 16:00–18:30 A19/229, Út 26. 1. 16:00–18:30 A19/229, Út 2. 2. 16:00–18:30 A19/229, J. Juřica
Předpoklady
aVLPF0622c Patologická fyziol. II - cv && aVLPA0622c Patologie II - cv.
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
The aims of the course are:
to recognize the basic pharmacological terminology and legislation related to the use of drugs and thei prescription
to understand to differences between single drug dosage forms
to understand to the prescription of drugs
to understand to the basics of pharmacokinetics
to understand to the basic facts about the discussed drugs
Výstupy z učení
At the end of the course the student knows:
single pharmacoterapeutical drug clases
single drug dosage forms
the modes of action, adverse reactions and basic indications of single drugs of discussed drugs
how to prescribe selected medical preparation or a drug in particular drug dosage form
Osnova
  • aVLFA0721c - Pharmacology I - practical lessons

    General medicine

    Autumn semester 2020

  • 12. 10. – 16. 10. 2020
  • Topic 1: INFORMATION ON DRUGS
  • Organisation of practical courses and lectures, system of evaluation. Repetition of basic pharmacologic terminology. Sub-branches of pharmacology. Sources of information concerning drugs and recommended textbooks. Work with relevant databases (Brevíř, SÚKL, EMA, AISLP), ATC classification.
  • 19. 10. – 23. 10. 2020
  • Topic 2: ROUTES OF DRUG ADMINISTRATION, DRUG DOSAGE FORMS
  • Brief characteristics of the individual drug dosage forms. Clinical significance of the way of drug administration.
  • 26. 10. – 30. 10. 2020
  • Topic 3: PRESCRIPTION OF MEDICAL PRODUCTS
  • General rules of drug prescription. Prescription of the ready-made preparations, drug dosage forms.
  • 2. 11. – 6.11. 2020
  • Topic 4: PHARMACOKINETICS I
  • Pharmacokinetic processes, parameters and calculations.
  • 9. 11. – 13. 11. 2020
  • Topic 5: PHARMACOKINETICS II
  • Pharmacokinetic case reports, simulation of plasma concentrations course, dosage optimalization and use of software tools, factors affecting course and value of drug´s plasma concentrations.
  • 16. 11. – 20. 11. 2020
  • Topic 6: PHARMACODYNAMICS
  • MULTIPLE-CHOICE TEST 1(Topics 1-5).
  • Mechanisms of drug effects - classification, examples. Dose-response curves.
  • 23. 11. – 27. 11. 2020
  • Topic 7: FACTORS AFFECTING DRUG EFFECTS
  • Pharmacotherapy in childhood, in pregnancy, in breastfeeding women, in elderly. Beer's list, STOPP-START, FORTA. Pharmacogenetics.
  • 30. 11. – 4. 12. 2020
  • Topic 8: PHARMACOVIGILANCE, ADVERSE DRUG REACTIONS
  • PRESCRIPTION TEST
  • Classification and characteristics of adverse drug effects. Pharmacovigilance in clinical practice, sources of current information on drug safety.
  • 7. 12. – 11. 12. 2020
  • Topic 9: PHARMACOLOGY OF SYMPATHETIC NERVOUS SYSTEM
  • Receptors of the sympathetic nervous system (alpha, beta) and parasympathetic nervous system (nicotinic, muscarinic) and their subtypes and organ distribution. Classification and basic pharmacological characteristics of drugs influencing sympathetic nervous system (pharmacodynamics - both direct and indirect mechanisms of drug action, systems of second messengers).
  • 14. 12. – 18. 12. 2020
  • Topic 10: PHARMACOLOGY OF PARASYMPATHETIC NERVOUS SYSTEM, SPASMOLYTIC DRUGS
  • Drugs affecting parasympathetic nervous system - classification, basic pharmacological characteristics. Spasmolytic drugs.
  • 4. 1. – 8. 1. 2021
  • Topic 11: ANAESTHETIC DRUGS
  • MULTIPLE-CHOICE TEST 2 (Topics 6-10).
  • Basic pharmacological characteristics of general and local anaesthetic drugs and muscle relaxants. Premedication prior to general anaesthesia.
  • 11. 1. – 15. 1. 2021
  • Topic 12: ANALGESICS
  • Basic pharmacological characteristics of opioid and non-opioid analgesic drugs, antirheumatoid drugs and drugs used in gout.
  • 18. 1. – 22. 1. 2021
  • Topic 13: PHARMACOTHERAPY OF DIABETES MELLITUS
  • Anti-diabetic drugs - basic pharmacological characteristics. Drugs used in therapy of specific and acute conditions in diabetology. Combinations of insulins, insulin regimens.
  • 25. 1. – 29. 1. 2021
  • Topic 14: SEX HORMONES
  • Endocrine therapy, hormone replacement therapy, hormonal contraceptive drugs. Uterotonics and tocolytics.
  • 1. 2. – 5. 2. 2021
  • Topic 15: GLUCOCORTICOIDS, THYROID HORMONES
  • MULTIPLE-CHOICE TEST 3 (Topics 11-14).
  • Repetition of basic pharmacological characteristics of glucocorticoids and thyroid hormones.
Literatura
    povinná literatura
  • Practicals in Pharmacology, 2009, Náhradní obsah: http://portal.med.muni.cz/article-491-practicals-in-pharmacology.html
  • http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
  • RANG, H. P., James RITTER, R. J. FLOWER a Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016. xv, 760. ISBN 9780702053627. info
    doporučená literatura
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015. xi, 664. ISBN 9781451191776. info
    neurčeno
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014. xvii, 552. ISBN 9780702051432. info
  • Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • LÜLLMANN, Heinz, Lutz HEIN a Klaus MOHR. Color atlas of pharmacology. Translated by Detlef Bierger, Illustrated by Jürgen Wirth. 4th ed. Stuttgart: Thieme, 2011. x, 393. ISBN 9783137817048. info
  • Pharmacology. Edited by Michelle Alexia Clark. 5th ed. Baltimore: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2012. xii, 612. ISBN 9781451113143. info
Záložky
https://is.muni.cz/ln/tag/LF:aVLFA0721c!
Výukové metody
Classes take place periodically in the afternoon. The lectures are followed by practical exercises with discussion.

The lectures discuss the basic issues of the subject. This knowledge is further deepened via specific practical tasks in exercises.

Materials for self-study and preparation for exercises will be available in the interactive syllabus/study materials for each topic, including references to the relevant chapters in the textbook.

2 absences from practical lessons are possible.
Metody hodnocení
3 continuous multiple-choice tests (time limit: 15 min) and 1 prescription test in a paper form. MCQ tests will not be repeated. The prescription test can be repeated only twice.

Each multiple-choice test contains 15 questions. The number of correct answers is given. Student gets 1 point for each completely correct answer, i.e. maximum 15 points for each multiple-choice test; total 45 points for all three MCQ tests.

The prescription test consists of two read-made preparations. For both preparations, the active substance, the drug dosage form and the number of original packages to be prescribed will be listed. The prescription handbook will be available for the test.

To obtain credits, the student has to pass the prescription test successfully and also get at least 6 points from each single multiple-choice test and at least 20 points (minimum) from all three MCQ tests.

Note: Together with the new accreditation of the Pharmacology subject for students of General Medicine, a system of continuous assessment of the student was introduced, when the results achieved in multiple-choice tests in practical lessons and colloquium will be taken into account and included in the final mark from the subject.
Vyučovací jazyk
Angličtina
Informace učitele
Course Contents:

INTRODUCTION, TERMINOLOGY, DOSES, PHARMACOLOGICAL CALCULATIONS
GENERAL RULES OF THE DRUG PRESCRIPTION
FLUID DRUG DOSAGE FORMS FOR THE EXTERNAL USE, ORAL AND PARENTERAL USE. GASEOUS DRUG DOSAGE FORMS
SOLID DRUG DOSAGE FORMS. SOFT AND MELTING DRUG DOSAGE FORMS
ROUTES OF DRUG ADMINISTRATION
INTRODUCTION TO PHARMACOKINETICS, PRINCIPLES, PARAMETERS
PHARMACOKINETIC INTERACTIONS. THERAPEUTIC DRUG MONITORING
PHARMACODYNAMICS
ADVERSE DRUG REACTIONS
FACTORS AFFECTING DRUG EFFECTS
PHARMACOLOGY OF THE SYMPATHETIC NERVOUS SYSTEM SYMPATHOMIMETICS, SYMPATHOLYTICS
PHARMACOLOGY OF THE PARASYMPATHETIC NERVOUS SYSTEM CHOLINERGIC DRUGS, SPASMOLYTICS
PHARMACOLOGY OF ENDOCRINE SYSTEM
GLUCOCORTICOIDS
ANTI-DIABETIC DRUGS
SEX HORMONES, UTEROTONICS, TOCOLYTICS
ANALGESIC DRUGS
ANTIRHEUMATOID DRUGS
DRUGS USED IN GOUT
ANAESTHETIC DRUGS
MUSCLE RELAXANTS
Další komentáře
Studijní materiály
Předmět je vyučován každoročně.
Předmět je zařazen také v obdobích podzim 2017, podzim 2018, podzim 2019, podzim 2021.