FDBCa_FAF Biochemistry

Farmaceutická fakulta
podzim 2025
Rozsah
2/0/0. 5 kr. Ukončení: zk.
Vyučováno kontaktně
Vyučující
Mgr. Marie Brázdová, Ph.D. (přednášející)
Garance
Mgr. Marie Brázdová, Ph.D.
Farmaceutická fakulta
Dodavatelské pracoviště: Ústav molekulární farmacie – Ústavy – Farmaceutická fakulta
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
Biochemistry is aimed at deepening the knowledge of biochemistry obtained in the undergraduate study. It focuses on detailed information on selected chemical processes in living organisms relevant to the study of DSP. Special emphasis is placed on modern information and links between biochemistry and molecular biology.
Výstupy z učení
Deepening basic knowledge of biochemistry forming the basis for related subjects. After completing the course, the student will be able to: - use the information obtained to understand the molecular basis of the effect of many drugs Advanced biochemical methods Knowledge of metabolic processes Cellular signalling pathways
Osnova
1) Biochemistry: Biochemistry of deepening basic knowledge
1.1) Scope of biochemistry: central principles, cellular and chemical foundations (functional groups, reactions), physical foundations
1.2) Living cells (structure of eukaryotic cell)
1.3) Water: the medium of life (interactions, pH, pKa, buffers, blood, liver and urine buffering systems, osmosis, dialysis)
1.4) Energy (free energy, ATP)
2) Structure and function of proteins
2.1) Amino acids (structure, pKa, pI, properties, covalent modifications)
2.2) Peptides (peptide bound, disulfide bridge, glutathione, insulin, antibiotics, neurotransmiters)
2.3) Protein structure (secondary, tertiary, conformation, structure and function)
2.4) Structure and function of hemoglobin and myoglobin
3) Enzymes
3.1) Properties of Enzymes (cofactors, coenzymes, vitamins)
3.2) Classification of Enzymes (examples of each class)
3.3) Catalysis (enzyme reaction, active site, specificity) and Enzyme regulation
3.4) Kinetics of enzyme reactions
4) Membrane transport
4.1) Biomembranes - composition and function
4.2) Membrane transports
5) Carbohydrates and metabolism of carbohydrate
5.1) Monosaccharides, Disaccharides, Oligosaccharides
5.2) Polysaccharides (structure and function)
5.3) Metabolism, homeostasis, catabolism, anabolism, nutrient pool, energy metabolism
5.4) Glycolysis and Glyconeogenesis
5.5) Glycogen metabolism
6) Metabolism of Proteins and Amino Acid Nitrogen
6.1) Overview of metabolism of proteins,
6.2) Elimination of alfa-amino nitrogen
6.3) Detoxification of Ammonia
6.4) Catabolism of Amino Acids (Ala, Arg, Ser, Gly, Thr, Asp, Glu, His, Phe, Tyr, Cys)
7) Aerobic metabolism
6.1) Tricarboxy Acid Cycle (Citric Acid Cycle (overview, fuels, mitochondrion, enzymes and coenzymes, 8 steps of CC, regulation of pyruvate dehydrogenase, control of CC, biosynthesis aspects of CC)
6.2) Respiratory chain (redox potential, sequence of electron carriers)
6.3) Oxidative phosphorylation (enzymes, prosthetic groups, localization in mitochondria, mechanism ATP synthesis)
6.4) Oxidative stress (reactive oxygen species, their formation, antioxidant enzymes systems, antioxidant molecules)
7) Lipids
7.1) Lipids classes (definition, biological) and metabolism
7.2) Synthesis and degradation of Fatty acids
7.3) Lipid synthesis. Peroxidation and Eicosanoids.
7.4 Biotransformation
8) Nucleic acids and their metabolism
8.1) Structure of components, role of nucleotides, biosynthesis (replication, transcription and proteosynthesis
8.2) Nucleic acids metabolism (biosynthesis and degradation of purine and pyrimidine nucleotides)
9) Integration of metabolism and cell signaling
Literatura
    povinná literatura
  • KENNELLY, Peter J.; Kathleen M. BOTHAM; Owen P. MCGUINNESS; Victor W. RODWELL a P. Anthony WEIL. Harper's illustrated biochemistry. Thirty-second edition. New York: McGraw-Hill, 2023, x, 802. ISBN 9781260469943. info
  • MURRAY, Robert K.; David A. BENDER; Kathleen M. BOTHAM; Peter J. KENNELLY; Victor W. RODWELL a P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012, xii, 730. ISBN 9788072629077. info
    doporučená literatura
  • MURPHY, Michael J.; Rajeev SRIVASTAVA a Kevin DEANS. Clinical biochemistry : an illustrated colour text. Seventh edition. [Philadelphia]: Elsevier, 2024, ix, 185. ISBN 9780323880572. info
  • Medical biochemistry. Edited by John W. Baynes - Marek H. Dominiczak. Sixth edition. [Amsterdam]: Elsevier, 2022, xxiv, 720. ISBN 9780323834506. info
  • COLE, Laurence A. a Peter R. KRAMER. Human physiology, biochemistry and basic medicine. Amsterdam: Elsevier, 2016, 1 online. ISBN 9780128037171. URL info
  • Robert K. Murray, Daryl K. Granner, Peter A. Mayes, Victor W. Ro. Harperova biochemie. ČR, 2002. ISBN 80-7319-013-3. info
Výukové metody
Teaching takes the form of personal consultations and other educational activities, that are recommended by the guarantor of the course.
Metody hodnocení
Ústní zkouška.
Vyučovací jazyk
Angličtina
Předmět je zařazen také v obdobích jaro 2025, jaro 2026.
  • Statistika zápisu (nejnovější)
  • Permalink: https://is.muni.cz/predmet/pharm/podzim2025/FDBCa_FAF