FaF:FDFTa_FAF Pharmaceutical Technology - Informace o předmětu

FDFTa_FAF Pharmaceutical Technology

Rozsah

2/0/0. 8 kr. Ukončení: zk.
Vyučováno kontaktně

Vyučující

doc. PharmDr. Kateřina Kubová, Ph.D. (přednášející)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (přednášející)

Garance

prof. PharmDr. Mgr. David Vetchý, Ph.D.
Farmaceutická fakulta
Dodavatelské pracoviště: Ústav farmaceutické technologie – Ústavy – Farmaceutická fakulta

Omezení zápisu do předmětu

Předmět je určen pouze studentům mateřských oborů.

Mateřské obory/plány

• Pharmacy (program FaF, D-FARMA) (2)

Cíle předmětu

The content of the subject is the issue of technological procedures leading to the design of a stable pharmaceutical form, which has the desired release of the drug and it is possible to manufacture it industrially, methods of their evaluation by the methods described in scientific and professional publications with emphasis on the knowledge of science and research contained in world databases and increasing the student's ability to process the knowledge gained from the field of pharmaceutical technology principles into research texts.

Výstupy z učení

Comprehensive knowledge in the field of pharmaceutical technology, above-standard knowledge in issues related to the field of student research.

Osnova

1. Parenteral dosage forms
2. Mucoadhesion and its application in drug technology, mucoadhesive agents.
3. Interactive powder mixtures (preparation methods, physico-chemical characteristics affecting the properties of the interactive powder mixture)
4. Pellets (physical-chemical properties, preparation, evaluation)
5. Plant extracts (physical-chemical properties, preparation, evaluation)
6. Controlled release and its characteristics (pulse, delayed, prolonged)
7. Good Manufacturing Practice (Basic Principles and Legislation)
8. Validation of the production of medicinal products (critical steps, statistical methods, basic documents)
9. Controlled release drug matrix tablets
10. Lipophilic auxiliaries and their use in matrix systems technology
11. Evaluation of solid dosage forms
12. Powders as a pharmaceutical form and intermediate for preparation of granules, tablets and capsules preparation and evaluation
13. Solid state drug, polymorphs, amorphous phases, salts and co-crystals
14. Assessment of the release of the drug from the pharmaceutical form of the pharmacopoeial and non-pharmacopoeial methods
15. Drug microforms, technology for their preparation and use in pharmacotherapy.
16. Microparticles. Possibilities to influence the quality parameters of microparticles prepared by external ion gelation.
17. The use of lactic acid and glycolic acid copolymer in pharmaceutical technology (its properties, PLGA microparticles, PLGA implants)
18. Transdermal dosage forms and their evaluation.
19. Use of swelling cellulose derivatives in drug mold technology
20. Texture analysis in the evaluation of solid dosage forms
21. Granulates and granulation technologies
22. Orodispersible dosage forms
23. Stability testing of the medical forms
24. Capsules method of preparation, manufacture, types and uses
25. Pharmacopoeial evaluation of flow properties
26. Pharmacopoeial evaluation of the tablets
27. Distribution of essential excipients for tablet production
28. Matrix controlled release systems
29. Tablets (preparation, evaluation)
30. Biorelevant dissolution method (media, pH, sampling times, dissolution devices)
31. Statistical methods used to assess the content uniformity of dosage forms
32. Delayed and pulsed-release dosage forms (preparation, evaluation)
33. Coated preparations (coating materials and methods of coating of oral medicinal products)
34. Sterile medicinal products (preparation, evaluation, use)
35. Analytical evaluation of polymer materials (overview of methods and their utilization, gel chromatography)
36. Oral dosage forms (distribution according to pharmacopoeia, preparation, excipients ...)
37. IN VITRO IN VIVO correlation in drug development.
38. Kinetic models for releasing drug substance from a pharmaceutical form
39. Possibilities of preparation of a specific solid phase to influence the rate of dissolution and bioavailability
40. Rheological measurements in the evaluation of drug forms
41. Cellulose and its derivatives in the technology of pharmaceutical forms and medical devices.
42. Natural polymers in the technology of pharmaceutical forms and medical devices.
43. Hydrophilic gels - technology of preparation and production, auxiliaries.
44. Topical semi-solid preparations - distribution, technological aspects, auxiliaries.
45. Modern medical devices (wound healing) in wound therapy - characteristics, requirements, overview.
46. Methods of preparation / production of polymer films.
47. Excipients for the preparation / production of polymer films.
48. Application of polymer films in pharmacy (pharmaceutical forms), health care and other fields.
49. Methods of evaluation of wound dressing quality.
50. Prolonged-release vaginal drugs (vaginal rings, vaginal inserts, mucoadhesive dosage forms)

Literatura

doporučená literatura
• Advanced and modern approaches for drug delivery. Edited by Amit Kumar Nayak - Md Saquib Hasnain - Bibek Laha - Sabayasachi Maiti. London: Academic Press, an imprint of Elsevier, 2023, 1 online. ISBN 9780323972192. URL info
• Fundamentals of drug delivery. Edited by Heather A. E. Benson - Michael S. Roberts - Adrian C. Williams - Xiaow. First published. Hoboken, NJ: John Wiley & Sons, 2022, xxii, 554. ISBN 9781119769606. info
• Advances and challenges in pharmaceutical technology : materials, process development and drug delivery strategies. Edited by Amit Kumar Nayak - Kunal Pal - Indranil Banerjee - Samarendra Maji - U. London: Academic Press, 2021, 1 online. ISBN 9780128203002. URL info
• Drug delivery : principles and applications. Edited by Binghe Wang - Longqin Hu - Teruna Siahaan. Second edition. Hoboken, New Jersey: Wiley, 2016, 1 online. ISBN 9781118833230. URL info
• Komárek, P., Rabišková, M. Technologie léků. Galén, Praha, 2006. ISBN 80-7262-423-7. info

Výukové metody

Self-study, consultations

Metody hodnocení

Oral examination

Vyučovací jazyk

Angličtina

• Statistika zápisu (nejnovější)
  
• Permalink: https://is.muni.cz/predmet/pharm/podzim2025/FDFTa_FAF