FDMOa_FAF Molecular Biology

Farmaceutická fakulta
podzim 2025
Rozsah
2/0/0. 5 kr. Ukončení: zk.
Vyučováno kontaktně
Vyučující
Mgr. Marie Brázdová, Ph.D. (přednášející)
Garance
Mgr. Marie Brázdová, Ph.D.
Farmaceutická fakulta
Dodavatelské pracoviště: Ústav molekulární farmacie – Ústavy – Farmaceutická fakulta
Předpoklady
Předmět je realizován formou konzultací a samostudia, předpokládá zvládnutí studijní literatury a pochopení souvislostí. Předpokládá základní znalosti molekulární biologie.
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
Molecular biology for DSP as a discipline which aims to study cellular biological processes at their molecular level. Learning outcomes of the course unit aim to acquaint the student with current trends and methods, especially for testing the bioactivity of natural substances at the molecular level.
Výstupy z učení
Knowledge of methodology used in molecular biology Knowledge of basic interactions of natural compounds with molecular targets Knowledge of molecular biology forming the basis for follow-up subjects Methods of molecular biology, Biotechnology of drugs, Exercises from drug biotechnology, Pharmacogenomics, Structure and evolution of genomes. After completing the course, the student will be able to: - identify and summarize important features on the structure of proteins and nucleic acids and the functions and relationships of information macromolecules in the transmission of genetic information; - describe the structure of prokaryotic and eukaryotic genomes, with mechanisms of replication, transcription, translation and regulation of gene expression; - describe the molecular mechanisms of mutagenesis, recombination and transposition, repair mechanisms and the molecular nature of carcinogenesis.
Osnova
1) Molecular biology and its position in biological sciences, milestones, personalities, central dogma of molecular biology
2) Information macromolecules, their structure, function and interaction in gene expression, genetic code.
3) Structure of prokaryotic genome, replication and gene expression in prokaryotes.
4) Structure of eukaryotic genome, replication and gene expression in eukaryotes.
5) Regulation of gene expression, molecular signalling.
6) RNA interference
7) Molecular biology of viruses, replication, expression of bacterial and animal virus's genes.
8) Mutagenesis, spontaneous and induced mutation and reversion.
9) Molecular basis of recombination, recombinantion in genetics.
10) Transposons, mechanisms of transposition, retroelements, retroviruses.
11) Reparation and excision mechanisms.
12) Molecular basis of cancerogenesis, protooncogenes and oncogenes, suppressor genes, oncoviruses.
13) Cell cycle and apoptosis
Literatura
    doporučená literatura
  • CHANDAR, Nalini a Susan VISELLI. Lippincott illustrated reviews : cell and molecular biology. Third edition. Philadelphia: Wolters Kluwer, 2024, 270 stran. ISBN 9781975180898. info
  • ALBERTS, Bruce; Rebecca HEALD; Alexander JOHNSON; David Owen MORGAN; Martin C. RAFF; Keith ROBERTS a Peter WALTER. Molecular biology of the cell. Edited by John H. Wilson - Tim Hunt. Seventh edition. New York, NY: W. W. Norton & Company, 2022, xxxviii, 1. ISBN 9780393884821. info
  • LODISH, Harvey F.; Arnold BERK; Chris KAISER; Monty KRIEGER; Anthony BRETSCHER; Hidde Lolke PLOEGH; Angelika AMON; Kelsey C. MARTIN a Michael B. YAFFE. Molecular cell biology. Ninth edition. New York: Macmillan International Higher Education, 2021, xliii, 118. ISBN 9781319365486. info
  • LIEBERMAN, Michael a Rick E. RICER. Biochemistry, molecular biology and genetics. Seventh edition. Philadelphia: Wolters Kluwer Health, 2019, xi, 444. ISBN 9781496399236. info
  • D. Peter Snustad Michael J. Simmons. Genetika. Brno, 2017. ISBN 9788021086135. info
  • MCLENNAN, Alexander G.; Andy BATES; Phil TURNER a Mike WHITE. Molecular biology. Fourth edition. New York: Garland Science, 2013, 1 online. ISBN 9781283860765. URL info
Výukové metody
Methods of working with text (textbook, book)
Metody hodnocení
Ústní zkouška
Vyučovací jazyk
Angličtina
Předmět je zařazen také v obdobích jaro 2025, jaro 2026.
  • Statistika zápisu (nejnovější)
  • Permalink: https://is.muni.cz/predmet/pharm/podzim2025/FDMOa_FAF