aFAFI1_14 Pharmacokinetics and Biopharmacy

Farmaceutická fakulta
podzim 2025

Předmět se v období podzim 2025 nevypisuje.

Rozsah
1/1/0. 14p+14s. 3 kr. Ukončení: zk.
Vyučující
PharmDr. Tereza Kauerová, Ph.D. (přednášející)
PharmDr. Tereza Kauerová, Ph.D. (cvičící)
Garance
PharmDr. Tereza Kauerová, Ph.D.
Ústav farmakologie a toxikologie – Ústavy – Farmaceutická fakulta
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
Pharmacokinetics course deals with the fundamental principles of absorption, distribution, metabolism, and the elimination of drugs by the human body in time as well as clinical application, including case studies of commonly dosed drugs. Basic aim of education in Pharmacokinetics for students of pharmacy is getting deep knowledge in processes, which take place in relation to time course of drug after administration. Understanding of pharmacokinetics patterns is important for insight into rational drug dosage in clinical practise. Application of the pharmacokinetic theory to clinical problems involved in optimizing and monitoring drug use in patients is important part of pharmacists work.
Výstupy z učení
After completing the course the student is able to explain the general rules regarding the pharmacokinetic processess and clinical significance and application od pharmacokinetic parameters. Student can also define and characterize different factors affecting the drug kinetics and thus pharmacotherapy. The student will be able to apply the acquired knowledge in a safe and effective pharmacotherapy.
Osnova
  • - Introduction to pharmacokinetics (pharmacokinetic processes,basic pharmacokinetic principles)
  • - Description of the pharmacokinetic processes (absorption, distribution, metabolism, and the excretion of drugs)
  • - Pharmacokinetic parameters (description of pharmacokinetic parameters and their clinical importance)
  • - Factors of non-genetic origin affecting the drug kinetics
  • - Factors of genetic origin affecting the drug kinetics
  • - Pharmacokinetic interactions - description
  • - Pharmacokinetic interactions - casuistics solution
  • - Bioequivalence. Pharmacokinetics in the clinical trials
  • - TDM - Therapeutic Drug Monitoring (Description and general principles, methodic and procedures of TDM in clinical practice)
  • - Special kinetics: Cytostatics
  • - Special kinetics: Antibiotics
Literatura
    doporučená literatura
  • Whalen K. Lippincott Illustrated Reviews: Pharmacology, 7th edition. Lippincott Williams & Wilkins, USA, 2018. ISBN 978-1496384133. info
  • Humphrey P. Rang, Maureen M. Dale, James M. Ritter and Rod J. Fl. Rang & Dale's Pharmacology, 8th Edition. 2016. ISBN 978-0702053627. info
  • Trevor A, Katzung B, Masters S., Knuidering-Hall M. Katzung & Trevor's Pharmacology Examination and Board Review. McGraw-Hill Medical, 2012. ISBN 0071789235. info
  • Katzung BG. Basic and Clinical Pharmacology. McGraw-Hill Medical, 2011. ISBN 978-0071764018. info
Výukové metody
Lectures, seminars (discussion, case studies, work with information sources)
Metody hodnocení
Written exam
Vyučovací jazyk
Angličtina
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