aFAFY1_13 Physical Pharmacy

Farmaceutická fakulta
jaro 2026
Rozsah
2/2/0. 28p+28c. 5 kr. Ukončení: zk.
Vyučující
doc. Mgr. Jan Muselík, Ph.D. (přednášející)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (přednášející)
doc. Mgr. Jan Muselík, Ph.D. (cvičící)
Mgr. Sylvie Pavloková, Ph.D. (cvičící)
PharmDr. Jiří Zeman, Ph.D. (cvičící)
Garance
prof. PharmDr. Mgr. David Vetchý, Ph.D.
Ústav farmaceutické technologie – Ústavy – Farmaceutická fakulta
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
The aim of the course is to make students familiar with basic knowledge of the physical chemistry, which constitutes part of the theoretical basis, necessary for understanding of processes delivered within disciplines in further stages of the study. Lectures are divided according to basic part of physical and colloid chemistry such as thermodynamics, kinetics of chemical reactions, behaviour of solutions, electrochemistry, phase equilibria, behaviour of phase interfaces, rheology, and colloidal systems. In laboratory exercises, students will learn the experimental techniques of physical chemistry. In seminars, students will get acquainted with physicochemical calculations, which are integral part of the knowledge required in the discipline.
Výstupy z učení
After completing the course, the student will be able to:
– describe the thermodynamic nature of a number of pharmaceutical processes;
– describe the factors that influence the solubility and dissolution of substances;
– determine and describe kinetic parameters in pharmaceutical processes;
– identify and summarize important features of electrochemical and phase phenomena;
– apply rheological principles to a practical problem;
– identify and summarize important characteristics of colloidal systems.
Osnova
  • LECTURES:
  • Thermodynamics.
  • Solubility: solubility gas/liquid, liquid/liquid, solid/liquid, solubility of salts, poor soluble electrolytes, weak electrolytes and their salts.
  • Electrochemistry.
  • Phase equilibria.
  • Phase interfaces.
  • Diffusion, dissolution and their importance in drug development.
  • Kinetics: rates and orders of reactions. Influence of temperature and other factors on reaction rates. The importance of kinetics in formulation and development of pharmaceuticals.
  • Rheology: Newtonian systems, non-Newtonian systems, thixotropy, determination of rheologic properties, viscoelasticity, application in pharmacy.
  • Colloids.

  • SEMINARS:
  • States of matter and thermodynamics – calculations.
  • Phase equilibria, chemical kinetics and electrochemistry – calculations.
  • Written test – calculations.

  • LABORATORY EXERCISES:
  • Density determination by pycnometric method.
  • Partitioning of succinic acid in the system butanol-water.
  • Determination of upper critical dissolution temperature of the mixture phenol-water.
  • Writtent test – theory from laboratory exercises.
Literatura
    doporučená literatura
  • HAMMES, Gordon G. a Sharon HAMMES-SCHIFFER. Physical chemistry for the biological sciences. Second edition. Hoboken, NJ: Wiley, 2015, 1 online. ISBN 9781118859148. URL info
  • Martin's physical pharmacy and pharmaceutical sciences : physical chemical and biopharmaceutical principles in the pharmaceutical sciences. Edited by Patrick J. Sinko - Yashveer Singh. Sixth edition. Philadelphia: Wolters Kluwer, 2011, viii, 659. ISBN 9781609134020. info
Výukové metody
lectures, practical classes (calculations, laboratory exercises)
Metody hodnocení
intermediate written tests and a final written exam
Vyučovací jazyk
Angličtina
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