aFAVG1_13 Advanced Drug Delivery and Technologies

Farmaceutická fakulta
jaro 2026

Předmět se v období jaro 2026 nevypisuje.

Rozsah
2/2/0. 28p+28c. 5 kr. Ukončení: zk.
Vyučující
PharmDr. Jan Elbl, Ph.D. (přednášející)
doc. PharmDr. Aleš Franc, Ph.D. (přednášející)
doc. PharmDr. Jan Gajdziok, Ph.D. (přednášející)
PharmDr. Hana Hořavová (přednášející)
doc. PharmDr. Kateřina Kubová, Ph.D. (přednášející)
doc. PharmDr. Ruta Masteiková, CSc. (přednášející)
PharmDr. Jakub Vysloužil, Ph.D. (přednášející)
PharmDr. Jan Elbl, Ph.D. (cvičící)
doc. PharmDr. Aleš Franc, Ph.D. (cvičící)
doc. PharmDr. Jan Gajdziok, Ph.D. (cvičící)
PharmDr. Hana Hořavová (cvičící)
doc. PharmDr. Kateřina Kubová, Ph.D. (cvičící)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (cvičící)
PharmDr. Jakub Vysloužil, Ph.D. (cvičící)
Garance
doc. PharmDr. Jan Gajdziok, Ph.D.
Ústav farmaceutické technologie – Ústavy – Farmaceutická fakulta
Kontaktní osoba: doc. PharmDr. Jan Gajdziok, Ph.D.
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
The course aims to acquaint students with advanced dosage/application forms, modern methods of formulation, and evaluation methods, all emphasizing their application in pharmacotherapeutic practice. Theoretical lectures are suitably complemented by practical exercises in the form of laboratory workshops, where modern formulation procedures of dosage forms and methods of their evaluation will be presented.
Výstupy z učení
By completing this course, students gain a deeper knowledge of advanced dosage/application forms for systemic and local drug delivery from the perspective of pharmaceutical technology. An integral part is the study of excipients and technologies and the evaluation of these innovative dosage forms. The information obtained suits motivated students who want to work in the pharmaceutical industry/research or pharmacy.
Osnova
  • Lectures: 1) Pellets - preparation technologies and use in pharmacotherapy 2) Liquisolid systems - principles, preparation and application 3) Ocular therapeutic systems 4) Implants 5) Colon drug delivery systems and IBD solutions 6) Abuse resistant drug formulations and dose dumping 7) 3D printing as a tool for individualized therapy 8) Drug forms for pediatric patients 9) Spray techniques in drug formulation and co-processed excipients 10) Veterinary dosage forms 11) Nano- and innovative micro-forms 12) Gastro-retentive dosage forms 13) Electronic systems in pharmacotherapy 14) Use of artificial intelligence in drug formulation 15) Modern transdermal dosage forms
  • Exercise: 1) Preparation of pellets by extrusion/spheronization method 2) Methods of evaluation of technological parameters of dosage forms 3) Preparation of pellets by rotary agglomeration method 4) Preparation of microparticles by ion gelation method 5) Preparation of pellets by layering drug solution on inactive pellets and their evaluation by dislocation test 6) Preparation of liquisolid systems 7) Preparation of microparticles by spray drying
Literatura
    doporučená literatura
  • 3D printing and bioprinting for pharmaceutical and medical applications. Edited by Jose Luis Pedraz Muῆoz - Laura Saenz del Burgo Martínez - Gustavo P. First published. Boca Raton, FL: Elsevier, 2024, xviii, 314. ISBN 9781032228679. info
  • HILL, Ray G. a Duncan B. RICHARDS. Drug discovery and development : technology in transition. 3rd edition. [Edinburgh?]: Elsevier, 2022, ix, 373. ISBN 9780702078040. info
  • NG, Rick. Drugs : from discovery to approval. Third edition. Hoboken, New Jersey: Wiley Blackwell, 2015, 1 online. ISBN 9781118907221. URL info
  • Wise. Handbook of Pharmaceutical controlled drug release. USA, 2008. ISBN 0-8247-0369-3. info
  • Rathbone, Hadgraft, Roberts. Modified drug delivery technology. USA, 2006. ISBN 0-8247-0869-5. info
Výukové metody
Lectures, practical laboratory work.
Metody hodnocení
Oral/written examination, colloquium - moderated discussion with students about topics of this subject.
Vyučovací jazyk
Angličtina
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