FaF:FAFG2_12 Pharmacognosy II - Informace o předmětu

FAFG2_12 Pharmacognosy II

Rozsah

2/5/0. 10 kr. Ukončení: zk.

Vyučující

prof. PharmDr. Karel Šmejkal, Ph.D. (přednášející)
prof. PharmDr. Karel Šmejkal, Ph.D. (cvičící)
PharmDr. Martin Helcman (cvičící)
Mgr. Juraj Markuš (cvičící)
Mgr. Polina Shpet (pomocník)

Garance

prof. PharmDr. Karel Šmejkal, Ph.D.
Ústav přírodních léčiv – Ústavy – Farmaceutická fakulta

Rozvrh

Út 14:45–16:25 45-221

• Rozvrh seminárních/paralelních skupin:

FAFG2_12/01: St 7:30–11:40 45-229, M. Helcman, J. Markuš, K. Šmejkal

Předpoklady

FAFG1_12 Pharmacognosy I
Knowledge of organic chemistry, analytical chemistry, phytochemistry, biochemistry, physiology.
This knowledge will be strictly demanded.

Omezení zápisu do předmětu

Předmět je určen pouze studentům mateřských oborů.

Předmět si smí zapsat nejvýše 24 stud.
Momentální stav registrace a zápisu: zapsáno: 11/24, pouze zareg.: 0/24

Mateřské obory/plány

• Multidisciplinární studia na farmaceutické fakultě (program CST, KOS)
• Pharmacy (program FaF, M-FARMA)

Cíle předmětu

Pharmacognosy deals with the sources of natural drugs and the products of plant metabolism, used and useful for treatment, prophylaxis, and diagnosis in human and veterinary medicine.

Výstupy z učení

The student must be able to microscopically and macroscopically identify selected drugs, know their main content substances, use, basic biosynthetic reactions, basal classes of secondary metabolites. Know the main plants used in the pharmacy. Chemical characteristics of secondary metabolites, basic knowledge of structure-activity relationships, basic knowledge of adverse effects and interactions.

Osnova

• Syllabus of lectures
  " Drugs affecting the central and peripheral nervous system
  " Drugs affecting vegetative nervous system
  " Drugs affecting the cardiovascular system
  " Drugs affecting hemocoagulation, fibrinolysis and used as the substitution of blood plasma
  " Drugs affecting water balance of the organism
  " Drugs affecting the respiratory system
  " Drugs affecting the digestive system
  " Uterotonics, antiuratics, antiphlogistics
  " Dietetics, roborants, geriatrics, sources of vitamins, pomocní léčba od diabetes mellitus
  " Hormones, enzymes
  " Anti-infectious and anti-invasive drugs
  " Drugs used for their local activity
  " Biogenic additives
  " Natural substances inspirational for synthesis
  Laboratory practice summer half
  1. Drugs containing saccharides
  Identification
  Tests of purity
  2. Drugs containing polysaccharides and mucilages
  Identification
  Determination of swelling number
  3. Drugs containing phenolic glycosides
  Identification
  Chromatographic proof of arbutin and hydroquinone
  Titrating determination of arbutin
  4. Drugs containing cardioglycosides (Control test I)
  Identification
  Chromatographic proof
  Colorimetric determination
  5. Drugs containing antraquinone glycosides
  Identification
  Chromatographic proof
  Colorimetric determination of hypericin
  6. Drugs containing flavonoid glycosides
  Identification
  Colorimetric determination of flavonoids
  Chromatographic proof
  7. Drugs containing saponins (Control test II)
  Identification
  Determination of hemolytic activity on blood agar
  Determination of number of foamability according to Kofler
  Determination of glycyrrhizinic acid
  8. Drugs containing tannins
  Identification - color and precipitation reactions
  Chromatographic proof
  Colorimetric determination
  9. Drugs containing volatiles
  Identification
  Chromatographic proof
  Hydro distillation determination
  10. Drugs containing alkaloids I. (Control test III)
  Identification ? color and precipitation reactions
  Titration determination of tropane alkaloids
  11. Drugs containing alkaloids II.
  Identification - color and precipitation reactions
  Gravimetric determination of purine alkaloids
  Thin layer chromatography of poppy opium alkaloids
  12. Drugs containing bitter substances
  Identification
  Determination of number of bitterness
  13. Drugs containing mustard glycosides
  Identification and purity
  14. Drugs containing coumarins, anthocyanins (Control test IV)
  Chromatographic proof
  

Literatura

povinná literatura
• Dewick P. Medicinal natural products, a biosynthetic approach. Hoboken, 2008. ISBN 9780470741689. info
• Bruneton Jean. Pharmacognosy, Phytochemistry, Medicinal Plants. 1999. ISBN 1898298637. info

doporučená literatura
• Samuelsson G., Bohlin L. Drugs of Natural Origin. A Treatise of Pharmacognosy. 7th revised edition. 2015. info
• Evans W Ch. Trease and Evans' Pharmacognosy. 2009. ISBN 9780702029332. info
• Wichtl M. Herbal Drugs and Phytopharmaceuticals. 2002. info

Výukové metody

Dialogic (discussion, interview, brainstorming)
Methods of written actions (e.g., for comprehensive exams, final exams)
Demonstration
Exercise and work skills training
Laboratory work

Metody hodnocení

Practical examination - recognition of selected drugs, knowledge of content compounds, and their utilization Oral examination

Vyučovací jazyk

Angličtina

Informace učitele

Required for crediting:
100% attendance of all the practices
Passing the written tests (60% is required to pass)
Required for examination:
Basic knowledge of plant secondary metabolism, structures of pharmaceutically, pharmacologically, or toxicologically important compounds, drugs and plant names, pharmacological or technological effects, and usage, basic methods for identification and quantification.
General examination combining Pharmacognosy I and Pharmacognosy II
Apart of pharmacognosy examination is macroscopic recognition of 10 drugs and microscopic identification of three preparates.

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