FALF1_13 Theory of Dosage Forms

Farmaceutická fakulta
podzim 2023
Rozsah
2/1/0. 4 kr. Ukončení: zk.
Vyučující
prof. PharmDr. Mgr. David Vetchý, Ph.D. (přednášející)
doc. PharmDr. Jan Gajdziok, Ph.D. (přednášející)
PharmDr. Jan Elbl, Ph.D. (přednášející)
doc. Mgr. Jan Muselík, Ph.D. (cvičící)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (cvičící)
Garance
prof. PharmDr. Mgr. David Vetchý, Ph.D.
Ústav farmaceutické technologie – Ústavy – Farmaceutická fakulta
Rozvrh
Út 15:10–16:50 18-122
  • Rozvrh seminárních/paralelních skupin:
FALF1_13/01: Pá 22. 9. až Pá 20. 10. každý sudý pátek 8:00–8:50 18-122, každý sudý pátek 8:50–11:20 18-138; a Pá 3. 11. 8:00–8:50 18-122, J. Muselík
Předpoklady
FAKULTA(FaF) || OBOR(MUSFaF)
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
Obligatory subject presenting the basics in medicament formulation, methods and processes useful for their development, polymers suitable for medical form design, stability testing.
Výstupy z učení
After completing the course, the student will be able to:
- identify and classify the dosage form into one of the three generations according to the nature of the drug release;
- describe procedures leading to increased bioavailability of drugs;
- describe the production and evaluation of mucoadhesive systems, ion exchangers and biological dosage forms;
- describe the principles of 3D printing for the preparation of dosage forms;
- describe in vitro-in vivo modelsv in drug development
Osnova
  • LECTURES:
  • Introduction into the pharmaceutical technology, medical forms and drug delivery, the importance of biopharmacy and pharmacokinetics in formulation and development of pharmaceuticals. Generation of medical forms. Medical forms of the first generation.
  • Medical forms of the second and the third generation.
  • Physico-chemical factors influencing the effect of the drug.
  • Biological factors influencing the effect of the drug.
  • Preformulation studies, drug formulation, drug validation.
  • Increasing bioavailability of poorly water soluble drugs by their modification.
  • Increasing bioavailability of poorly water soluble drugs by technological methods facilitating drug dissolution.
  • Lipophilic formulations for increasing bioavailability of poorly water-soluble drugs.
  • Liquid-solid systems and their application in pharmacy. Medical forms based on these systems.
  • Mucoadhesive systems and their application in pharmacy. Medical forms based on these systems.
  • 3D printing and its application in pharmacy. Medical forms based on this technology.
  • Ion exchangers and their application in pharmacy. Medical forms based on ion exchangers. Production of biological dosage forms.
  • In vitro in vivo models in drug development.

    PRACTICAL TRAINING:
  • Surface tension measurement by stalagmometric method.
  • Preparation and evaluation of mucoadhesive oral films (MOF).
  • Evaluation of aggregate state of suspension.
Literatura
    povinná literatura
  • Sinko, P.T., Singh, Y. Martin's Physical Pharmacy 2011. info
Výukové metody
lectures, laboratory exercises
Metody hodnocení
credit, oral exam
Vyučovací jazyk
Angličtina
Informace učitele
Lectures recommended due to lack of suitable literature. Participate in exercises in the full range given by the syllabus and properly prepare protocols from laboratory exercises. Demonstrate ongoing knowledge in the preparation for laboratory exercices. The condition for participation in the exam is to obtain a credit.
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Předmět je dovoleno ukončit i mimo zkouškové období.
Předmět je zařazen také v obdobích podzim 2020, podzim 2021, podzim 2022, podzim 2024.