Grey-white matter abnormalities in temporal lobe epilepsy
associated with hippocampal sclerosis: Inter-observer analysis,
histopathological findings, and correlation with clinical
variables

J 2012

Grey-white matter abnormalities in temporal lobe epilepsy associated with hippocampal sclerosis: Inter-observer analysis, histopathological findings, and correlation with clinical variables

KUBA, Robert; Ivana TYRLÍKOVÁ; Marta PAŽOURKOVÁ; Markéta HERMANOVÁ; Iva HORÁKOVÁ et al.

Základní údaje

Originální název

Grey-white matter abnormalities in temporal lobe epilepsy associated with hippocampal sclerosis: Inter-observer analysis, histopathological findings, and correlation with clinical variables

Autoři

KUBA, Robert; Ivana TYRLÍKOVÁ; Marta PAŽOURKOVÁ; Markéta HERMANOVÁ; Iva HORÁKOVÁ; Milan BRÁZDIL a Ivan REKTOR

Vydání

Epilepsy Research, Amsterdam, Elsevier Science Publishers, 2012, 0920-1211

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.241

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/12:00062715

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1016/j.eplepsyres.2012.05.002

UT WoS

000311529400009

Klíčová slova anglicky

Grey-white matter abnormalities; Temporal lobe epilepsy; Focal cortical dysplasia; MRI

Příznaky

Mezinárodní význam

Změněno: 22. 4. 2013 18:21, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

This study was conducted to determine the incidence of grey-white matter abnormalities (GWMAs) on magnetic resonance images (MRIs) in patients with hippocampal sclerosis (HS), to assess the inter-observer reliability of this finding, and to establish a possible relationship between GWMA and histopathological findings in the anterior part of the temporal lobe, as well as its other relation to clinical variables. We established a group of 55 patients with histologically proven HS. Three observers independently reviewed the MRIs to assess whether GWMA was present. Substantial independent inter-observer agreement was reached for 44 of the 55 patients (80%) (Fleiss' kappa 0.732; p<0.0001). GWMAs were present in 38% of patients (HS + GWMA). Focal cortical dysplasia (FCD) of type Illa (ILAE classification) was present in 31% of patients. FCD type Illa was present in 52.4% with HS + GWMA, and in 17.6% without GWMA (HS - GWMA) (p=0.007). We did not find any statistically significant differences in the postoperative outcomes between HS + GWMA and HS - GWMA. We did not find any statistically significant differences in the presence or absence of GWMA and FCD of the temporal pole in relation to the onset of epilepsy, the duration of epilepsy, or the presence of potential epileptogenic insults. GWMA in the anterior part of temporal lobe in patients with HS is a reliable assessment sign for observers who are experienced in evaluating the MRIs of epilepsy patients. The presence of GWMA is significantly associated with the presence of FCD type Illa in these patients. The presence or absence of GWMA and FCD type Illa does not influence the postoperative outcome of HS patients. (C) 2012 Elsevier B.V. All rights reserved.

Citovat

KUBA, Robert; Ivana TYRLÍKOVÁ; Marta PAŽOURKOVÁ; Markéta HERMANOVÁ; Iva HORÁKOVÁ; Milan BRÁZDIL a Ivan REKTOR. Grey-white matter abnormalities in temporal lobe epilepsy associated with hippocampal sclerosis: Inter-observer analysis, histopathological findings, and correlation with clinical variables. Epilepsy Research. Amsterdam: Elsevier Science Publishers, 2012, roč. 102, 1-2, s. 78-85. ISSN 0920-1211. Dostupné z: https://doi.org/10.1016/j.eplepsyres.2012.05.002.

@article{1081089,
   author = {Kuba, Robert and Tyrlíková, Ivana and Pažourková, Marta and Hermanová, Markéta and Horáková, Iva and Brázdil, Milan and Rektor, Ivan},
   article_location = {Amsterdam},
   article_number = {1-2},
   doi = {https://doi.org/10.1016/j.eplepsyres.2012.05.002},
   keywords = {Grey-white matter abnormalities; Temporal lobe epilepsy; Focal cortical dysplasia; MRI},
   language = {eng},
   issn = {0920-1211},
   journal = {Epilepsy Research},
   title = {Grey-white matter abnormalities in temporal lobe epilepsy associated with hippocampal sclerosis: Inter-observer analysis, histopathological findings, and correlation with clinical variables},
   volume = {102},
   year = {2012}
}

TY  - JOUR
ID  - 1081089
AU  - Kuba, Robert - Tyrlíková, Ivana - Pažourková, Marta - Hermanová, Markéta - Horáková, Iva - Brázdil, Milan - Rektor, Ivan
PY  - 2012
TI  - Grey-white matter abnormalities in temporal lobe epilepsy associated with hippocampal sclerosis: Inter-observer analysis, histopathological findings, and correlation with clinical variables
JF  - Epilepsy Research
VL  - 102
IS  - 1-2
SP  - 78-85
EP  - 78-85
PB  - Elsevier Science Publishers
SN  - 09201211
KW  - Grey-white matter abnormalities
KW  - Temporal lobe epilepsy
KW  - Focal cortical dysplasia
KW  - MRI
N2  - This study was conducted to determine the incidence of grey-white matter abnormalities (GWMAs) on magnetic resonance images (MRIs) in patients with hippocampal sclerosis (HS), to assess the inter-observer reliability of this finding, and to establish a possible relationship between GWMA and histopathological findings in the anterior part of the temporal lobe, as well as its other relation to clinical variables. We established a group of 55 patients with histologically proven HS. Three observers independently reviewed the MRIs to assess whether GWMA was present. Substantial independent inter-observer agreement was reached for 44 of the 55 patients (80%) (Fleiss' kappa 0.732; p<0.0001). GWMAs were present in 38% of patients (HS + GWMA). Focal cortical dysplasia (FCD) of type Illa (ILAE classification) was present in 31% of patients. FCD type Illa was present in 52.4% with HS + GWMA, and in 17.6% without GWMA (HS - GWMA) (p=0.007). We did not find any statistically significant differences in the postoperative outcomes between HS + GWMA and HS - GWMA. We did not find any statistically significant differences in the presence or absence of GWMA and FCD of the temporal pole in relation to the onset of epilepsy, the duration of epilepsy, or the presence of potential epileptogenic insults. GWMA in the anterior part of temporal lobe in patients with HS is a reliable assessment sign for observers who are experienced in evaluating the MRIs of epilepsy patients. The presence of GWMA is significantly associated with the presence of FCD type Illa in these patients. The presence or absence of GWMA and FCD type Illa does not influence the postoperative outcome of HS patients. (C) 2012 Elsevier B.V. All rights reserved.
ER  -

KUBA, Robert; Ivana TYRLÍKOVÁ; Marta PAŽOURKOVÁ; Markéta HERMANOVÁ; Iva HORÁKOVÁ; Milan BRÁZDIL a Ivan REKTOR. Grey-white matter abnormalities in temporal lobe epilepsy associated with hippocampal sclerosis: Inter-observer analysis, histopathological findings, and correlation with clinical variables. \textit{Epilepsy Research}. Amsterdam: Elsevier Science Publishers, 2012, roč.~102, 1-2, s.~78-85. ISSN~0920-1211. Dostupné z: https://doi.org/10.1016/j.eplepsyres.2012.05.002.

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