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@article{1085782,
author = {Vaňhara, Petr and Souček, Karel},
article_location = {London},
article_number = {2},
doi = {http://dx.doi.org/10.4161/jkst.23810},
keywords = {metastasis; transforming growth factor-b; interleukin 11; metastatic niche; tumor stroma; dissemination; microenvironment},
language = {eng},
issn = {2162-3996},
journal = {JAK-STAT},
title = {Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases},
url = {https://www.landesbioscience.com/journals/jak-stat/2012JAKS0099.pdf},
volume = {2},
year = {2013}
}
TY - JOUR
ID - 1085782
AU - Vaňhara, Petr - Souček, Karel
PY - 2013
TI - Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases
JF - JAK-STAT
VL - 2
IS - 2
SP - 1-4
EP - 1-4
PB - Landes Bioscience
SN - 21623996
KW - metastasis
KW - transforming growth factor-b
KW - interleukin 11
KW - metastatic niche
KW - tumor stroma
KW - dissemination
KW - microenvironment
UR - https://www.landesbioscience.com/journals/jak-stat/2012JAKS0099.pdf
N2 - Tumor growth and cancer development are considered clear examples of Darwinian selection, whereby random mutational events in heterogeneous cancer cell populations that best fit the selective microenvironment are preferred.1 As a result, cancer cells evolve resistance to apoptosis, hide from immune surveillance and acquire the ability to invade other organs. Cancer cells, however, are not necessarily passive subjects of selection; they can actively subvert the host tissue to provide a favorable habitat for their growth. Recent findings by Calon et al. convincingly demonstrate that transforming growth factor-b-induced secretion of interleukin 11 by tumor stromal fibroblasts is a necessary prerequisite for the development of distant metastases in colorectal carcinoma. Thus, understanding the complex molecular feedback loops between cancer cells and the surrounding microenvironment (i.e., the tumor-associated stroma or invaded host tissue) should aid the identification of useful molecular targets for improving clinical management of advanced metastatic cancers.
ER -
VAŇHARA, Petr a Karel SOUČEK. Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases. \textit{JAK-STAT}. London: Landes Bioscience, 2013, roč.~2, č.~2, s.~1-4. ISSN~2162-3996. Dostupné z: https://dx.doi.org/10.4161/jkst.23810.
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