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@article{1104689, author = {Trčka, Filip and Šmarda, Jan and Knopfová, Lucia and Kuziaková, Kateřina and Beneš, Petr}, article_location = {NEW YORK}, article_number = {7}, doi = {http://dx.doi.org/10.1016/j.cellsig.2013.03.021}, keywords = {Differentiation; Myeloid cells; NFAT1; Proliferation; Retinoic acid; v-Myb}, language = {eng}, issn = {0898-6568}, journal = {Cellular Signalling}, title = {Nuclear factor of activated T-cells 1 increases sensitivity of v-myb transformed monoblasts to all-trans retinoic acid}, volume = {25/2013}, year = {2013} }
TY - JOUR ID - 1104689 AU - Trčka, Filip - Šmarda, Jan - Knopfová, Lucia - Kuziaková, Kateřina - Beneš, Petr PY - 2013 TI - Nuclear factor of activated T-cells 1 increases sensitivity of v-myb transformed monoblasts to all-trans retinoic acid JF - Cellular Signalling VL - 25/2013 IS - 7 SP - 1546-1555 EP - 1546-1555 PB - ELSEVIER SCIENCE INC SN - 08986568 KW - Differentiation KW - Myeloid cells KW - NFAT1 KW - Proliferation KW - Retinoic acid KW - v-Myb N2 - Nuclear factors of activated T-cells (NFATs) are important regulators of the cytokine gene expression in activated T-cells. In the last decade, NFATs have been shown to regulate cell cycle, differentiation and apoptosis in cells of various origins revealing their importance for cell homeostasis. In this study, we investigated the effects of NFAT1 on proliferation and differentiation of v-myb-transformed BM2 monoblasts. In contrast to many other leukemic cell lines, BM2 cells do not respond to retinoic acid. However, once overexpressing NFAT1, they became sensitive to all-trans retinoic acid (ATRA). The ATRA-treated BM2NFAT1 cells differentiated along monocyte/macrophage pathway as evidenced by changes in cell morphology, adherence, phagocytic and non-specific esterase activities, reactive oxygen species production, and vimentin expression. Furthermore, overexpressed NFAT1 either alone or in combination with the ATRA-driven signalling pathway deregulated cyclin A and retinoic acid receptor proteins in BM2 cells. Data presented in this study indicate that the NFAT1 and ATRA signalling pathways synergize in control of proliferation and differentiation of BM2 monoblasts. ER -
TRČKA, Filip, Jan ŠMARDA, Lucia KNOPFOVÁ, Kateřina KUZIAKOVÁ a Petr BENEŠ. Nuclear factor of activated T-cells 1 increases sensitivity of v-myb transformed monoblasts to all-trans retinoic acid. \textit{Cellular Signalling}. NEW YORK: ELSEVIER SCIENCE INC, 2013, roč.~25/2013, č.~7, s.~1546-1555. ISSN~0898-6568. Dostupné z: https://dx.doi.org/10.1016/j.cellsig.2013.03.021.
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