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@proceedings{1104700,
author = {Jančeková, Blanka and Ondroušková, Eva and Knopfová, Lucia and Beneš, Petr and Šmarda, Jan},
booktitle = {The Student Scientific Conference on Biotechnology & Biomedicine},
keywords = {Cathepsin D; Lysosomal cell death; breast cancer; TRAIL},
language = {eng},
isbn = {978-80-210-6200-9},
title = {Lysosomal pathway of the TRAIL-induced apoptosis in breast carcinoma cells-the role of the lysosomal protease cathepsin D},
year = {2013}
}
TY - CONF
ID - 1104700
AU - Jančeková, Blanka - Ondroušková, Eva - Knopfová, Lucia - Beneš, Petr - Šmarda, Jan
PY - 2013
TI - Lysosomal pathway of the TRAIL-induced apoptosis in breast carcinoma cells-the role of the lysosomal protease cathepsin D
SN - 9788021062009
KW - Cathepsin D
KW - Lysosomal cell death
KW - breast cancer
KW - TRAIL
N2 - In this study, we investigated the role of lysosomal aspartyl protease cathepsin D (CTSD( in the TRAIL-induced apoptosis. We showed that overexpression of CTSD sensitizes MDA-MB-231 breast carcinoma cells to the TRAIL-induced apoptosis in enzymatic activity-dependent manner. The increased frequency fo apoptosis observed in the CTSD-overexpressing cells corresponded to caspase activation and cleavage of the Bid protein, the pro-apoptotic BCL-2 family member. We also showed that the CTSD-mediated pro-apoptotic effect can be partially reversed by the caspase 8 and aspartyl protease inhibitors.
ER -
JANČEKOVÁ, Blanka, Eva ONDROUŠKOVÁ, Lucia KNOPFOVÁ, Petr BENEŠ a Jan ŠMARDA. Lysosomal pathway of the TRAIL-induced apoptosis in breast carcinoma cells-the role of the lysosomal protease cathepsin D. In \textit{The Student Scientific Conference on Biotechnology \&{} Biomedicine}. 2013. ISBN~978-80-210-6200-9.
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